A retrospective study on the therapeutic effects of sodium bicarbonate for adult in-hospital cardiac arrest

Abstract To investigate whether the effects of sodium bicarbonate (SB) during cardiopulmonary resuscitation (CPR) would be influenced by blood pH and administration timing. Adult patients experiencing in-hospital cardiac arrest (IHCA) from 2006 to 2015 were retrospectively screened. Early intra-arre...

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Autores principales:	Chih-Hung Wang, Cheng-Yi Wu, Meng-Che Wu, Wei-Tien Chang, Chien-Hua Huang, Min-Shan Tsai, Tsung-Chien Lu, Eric Chou, Yu-Lin Hsieh, Wen-Jone Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8d82d0e6e50a402a99eafff61e7a2eff
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spelling	oai:doaj.org-article:8d82d0e6e50a402a99eafff61e7a2eff2021-12-02T17:30:40ZA retrospective study on the therapeutic effects of sodium bicarbonate for adult in-hospital cardiac arrest10.1038/s41598-021-91936-32045-2322https://doaj.org/article/8d82d0e6e50a402a99eafff61e7a2eff2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91936-3https://doaj.org/toc/2045-2322Abstract To investigate whether the effects of sodium bicarbonate (SB) during cardiopulmonary resuscitation (CPR) would be influenced by blood pH and administration timing. Adult patients experiencing in-hospital cardiac arrest (IHCA) from 2006 to 2015 were retrospectively screened. Early intra-arrest blood gas data were obtained within 10 min of CPR. Multivariable logistic regression analysis and generalised additive models were used for effect estimation and data exploration, respectively. A total of 1060 patients were included. Only 59 patients demonstrated favourable neurological status at hospital discharge. Blood pH ≤ 7.18 was inversely associated with favourable neurological outcome (odds ratio [OR], 0.24; 95% confidence interval [CI], 0.11–0.52; p value < 0.001) while SB use was not. In the interaction analysis for favourable neurological outcome, significant interactions were noted between SB use and time to SB (SB use × time to SB ≥ 20 min; OR 6.16; 95% CI 1.42–26.75; p value = 0.02). In the interaction analysis for survival to hospital discharge, significant interactions were noted between SB use and blood pH (Non-SB use × blood pH > 7.18; OR 1.56; 95% CI 1.01–2.41; p value = 0.05). SB should not be empirically administered for patients with IHCA since its effects may be influenced by blood pH and administration timing.Chih-Hung WangCheng-Yi WuMeng-Che WuWei-Tien ChangChien-Hua HuangMin-Shan TsaiTsung-Chien LuEric ChouYu-Lin HsiehWen-Jone ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chih-Hung Wang Cheng-Yi Wu Meng-Che Wu Wei-Tien Chang Chien-Hua Huang Min-Shan Tsai Tsung-Chien Lu Eric Chou Yu-Lin Hsieh Wen-Jone Chen A retrospective study on the therapeutic effects of sodium bicarbonate for adult in-hospital cardiac arrest
description	Abstract To investigate whether the effects of sodium bicarbonate (SB) during cardiopulmonary resuscitation (CPR) would be influenced by blood pH and administration timing. Adult patients experiencing in-hospital cardiac arrest (IHCA) from 2006 to 2015 were retrospectively screened. Early intra-arrest blood gas data were obtained within 10 min of CPR. Multivariable logistic regression analysis and generalised additive models were used for effect estimation and data exploration, respectively. A total of 1060 patients were included. Only 59 patients demonstrated favourable neurological status at hospital discharge. Blood pH ≤ 7.18 was inversely associated with favourable neurological outcome (odds ratio [OR], 0.24; 95% confidence interval [CI], 0.11–0.52; p value < 0.001) while SB use was not. In the interaction analysis for favourable neurological outcome, significant interactions were noted between SB use and time to SB (SB use × time to SB ≥ 20 min; OR 6.16; 95% CI 1.42–26.75; p value = 0.02). In the interaction analysis for survival to hospital discharge, significant interactions were noted between SB use and blood pH (Non-SB use × blood pH > 7.18; OR 1.56; 95% CI 1.01–2.41; p value = 0.05). SB should not be empirically administered for patients with IHCA since its effects may be influenced by blood pH and administration timing.
format	article
author	Chih-Hung Wang Cheng-Yi Wu Meng-Che Wu Wei-Tien Chang Chien-Hua Huang Min-Shan Tsai Tsung-Chien Lu Eric Chou Yu-Lin Hsieh Wen-Jone Chen
author_facet	Chih-Hung Wang Cheng-Yi Wu Meng-Che Wu Wei-Tien Chang Chien-Hua Huang Min-Shan Tsai Tsung-Chien Lu Eric Chou Yu-Lin Hsieh Wen-Jone Chen
author_sort	Chih-Hung Wang
title	A retrospective study on the therapeutic effects of sodium bicarbonate for adult in-hospital cardiac arrest
title_short	A retrospective study on the therapeutic effects of sodium bicarbonate for adult in-hospital cardiac arrest
title_full	A retrospective study on the therapeutic effects of sodium bicarbonate for adult in-hospital cardiac arrest
title_fullStr	A retrospective study on the therapeutic effects of sodium bicarbonate for adult in-hospital cardiac arrest
title_full_unstemmed	A retrospective study on the therapeutic effects of sodium bicarbonate for adult in-hospital cardiac arrest
title_sort	retrospective study on the therapeutic effects of sodium bicarbonate for adult in-hospital cardiac arrest
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8d82d0e6e50a402a99eafff61e7a2eff
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A retrospective study on the therapeutic effects of sodium bicarbonate for adult in-hospital cardiac arrest

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