Modeling germline mutations in pineoblastoma uncovers lysosome disruption-based therapy

Pineoblastoma is a rare pediatric cancer. Here, the authors present inactivation of Rb plus p53 via a WAP-Cre transgene induces metastatic pineoblastoma resembling human disease, and using this model, predict tricyclic antidepressants as a potential therapy for pineoblastoma, supported by their pre-...

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Autores principales:	Philip E. D. Chung, Deena M. A. Gendoo, Ronak Ghanbari-Azarnier, Jeff C. Liu, Zhe Jiang, Jennifer Tsui, Dong-Yu Wang, Xiao Xiao, Bryan Li, Adrian Dubuc, David Shih, Marc Remke, Ben Ho, Livia Garzia, Yaacov Ben-David, Seok-Gu Kang, Sidney Croul, Benjamin Haibe-Kains, Annie Huang, Michael D. Taylor, Eldad Zacksenhaus
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8d8533d286084918a97e2d6644e11fc1
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spelling	oai:doaj.org-article:8d8533d286084918a97e2d6644e11fc12021-12-02T15:37:14ZModeling germline mutations in pineoblastoma uncovers lysosome disruption-based therapy10.1038/s41467-020-15585-22041-1723https://doaj.org/article/8d8533d286084918a97e2d6644e11fc12020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15585-2https://doaj.org/toc/2041-1723Pineoblastoma is a rare pediatric cancer. Here, the authors present inactivation of Rb plus p53 via a WAP-Cre transgene induces metastatic pineoblastoma resembling human disease, and using this model, predict tricyclic antidepressants as a potential therapy for pineoblastoma, supported by their pre-clinical model.Philip E. D. ChungDeena M. A. GendooRonak Ghanbari-AzarnierJeff C. LiuZhe JiangJennifer TsuiDong-Yu WangXiao XiaoBryan LiAdrian DubucDavid ShihMarc RemkeBen HoLivia GarziaYaacov Ben-DavidSeok-Gu KangSidney CroulBenjamin Haibe-KainsAnnie HuangMichael D. TaylorEldad ZacksenhausNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Philip E. D. Chung Deena M. A. Gendoo Ronak Ghanbari-Azarnier Jeff C. Liu Zhe Jiang Jennifer Tsui Dong-Yu Wang Xiao Xiao Bryan Li Adrian Dubuc David Shih Marc Remke Ben Ho Livia Garzia Yaacov Ben-David Seok-Gu Kang Sidney Croul Benjamin Haibe-Kains Annie Huang Michael D. Taylor Eldad Zacksenhaus Modeling germline mutations in pineoblastoma uncovers lysosome disruption-based therapy
description	Pineoblastoma is a rare pediatric cancer. Here, the authors present inactivation of Rb plus p53 via a WAP-Cre transgene induces metastatic pineoblastoma resembling human disease, and using this model, predict tricyclic antidepressants as a potential therapy for pineoblastoma, supported by their pre-clinical model.
format	article
author	Philip E. D. Chung Deena M. A. Gendoo Ronak Ghanbari-Azarnier Jeff C. Liu Zhe Jiang Jennifer Tsui Dong-Yu Wang Xiao Xiao Bryan Li Adrian Dubuc David Shih Marc Remke Ben Ho Livia Garzia Yaacov Ben-David Seok-Gu Kang Sidney Croul Benjamin Haibe-Kains Annie Huang Michael D. Taylor Eldad Zacksenhaus
author_facet	Philip E. D. Chung Deena M. A. Gendoo Ronak Ghanbari-Azarnier Jeff C. Liu Zhe Jiang Jennifer Tsui Dong-Yu Wang Xiao Xiao Bryan Li Adrian Dubuc David Shih Marc Remke Ben Ho Livia Garzia Yaacov Ben-David Seok-Gu Kang Sidney Croul Benjamin Haibe-Kains Annie Huang Michael D. Taylor Eldad Zacksenhaus
author_sort	Philip E. D. Chung
title	Modeling germline mutations in pineoblastoma uncovers lysosome disruption-based therapy
title_short	Modeling germline mutations in pineoblastoma uncovers lysosome disruption-based therapy
title_full	Modeling germline mutations in pineoblastoma uncovers lysosome disruption-based therapy
title_fullStr	Modeling germline mutations in pineoblastoma uncovers lysosome disruption-based therapy
title_full_unstemmed	Modeling germline mutations in pineoblastoma uncovers lysosome disruption-based therapy
title_sort	modeling germline mutations in pineoblastoma uncovers lysosome disruption-based therapy
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8d8533d286084918a97e2d6644e11fc1
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Modeling germline mutations in pineoblastoma uncovers lysosome disruption-based therapy

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