Hypoxia induced mitogenic factor (HIMF) triggers angiogenesis by increasing interleukin-18 production in myoblasts

Abstract Inflammatory myopathy is a rare autoimmune muscle disorder. Treatment typically focuses on skeletal muscle weakness or inflammation within muscle, as well as complications of respiratory failure secondary to respiratory muscle weakness. Impaired respiratory muscle function contributes to in...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Chen-Ming Su, I-Ching Wang, Shan-Chi Liu, Yi Sun, Lulu Jin, Shih-Wei Wang, Hsiang-Ping Lee, Wen-Pei Tseng, Chih-Hsin Tang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8d860b455da44fc887ad37bf0be8e6b8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8d860b455da44fc887ad37bf0be8e6b8
record_format	dspace
spelling	oai:doaj.org-article:8d860b455da44fc887ad37bf0be8e6b82021-12-02T16:06:47ZHypoxia induced mitogenic factor (HIMF) triggers angiogenesis by increasing interleukin-18 production in myoblasts10.1038/s41598-017-07952-92045-2322https://doaj.org/article/8d860b455da44fc887ad37bf0be8e6b82017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07952-9https://doaj.org/toc/2045-2322Abstract Inflammatory myopathy is a rare autoimmune muscle disorder. Treatment typically focuses on skeletal muscle weakness or inflammation within muscle, as well as complications of respiratory failure secondary to respiratory muscle weakness. Impaired respiratory muscle function contributes to increased dyspnea and reduced exercise capacity in pulmonary hypertension (PH), a debilitating condition that has few treatment options. The initiation and progression of PH is associated with inflammation and inflammatory cell recruitment and it is established that hypoxia-induced mitogenic factor (HIMF, also known as resistin-like molecule α), activates macrophages in PH. However, the relationship between HIMF and inflammatory myoblasts remains unclear. This study investigated the signaling pathway involved in interleukin-18 (IL-18) expression and its relationship with HIMF in cultured myoblasts. We found that HIMF increased IL-18 production in myoblasts and that secreted IL-18 promoted tube formation of the endothelial progenitor cells. We used the mouse xenograft model and the chick chorioallantoic membrane assay to further explore the role of HIMF in inflammatory myoblasts and angiogenesis in vivo. Thus, our study focused on the mechanism by which HIMF mediates IL-18 expression in myoblasts through angiogenesis in vitro and in vivo. Our findings provide an insight into HIMF functioning in inflammatory myoblasts.Chen-Ming SuI-Ching WangShan-Chi LiuYi SunLulu JinShih-Wei WangHsiang-Ping LeeWen-Pei TsengChih-Hsin TangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chen-Ming Su I-Ching Wang Shan-Chi Liu Yi Sun Lulu Jin Shih-Wei Wang Hsiang-Ping Lee Wen-Pei Tseng Chih-Hsin Tang Hypoxia induced mitogenic factor (HIMF) triggers angiogenesis by increasing interleukin-18 production in myoblasts
description	Abstract Inflammatory myopathy is a rare autoimmune muscle disorder. Treatment typically focuses on skeletal muscle weakness or inflammation within muscle, as well as complications of respiratory failure secondary to respiratory muscle weakness. Impaired respiratory muscle function contributes to increased dyspnea and reduced exercise capacity in pulmonary hypertension (PH), a debilitating condition that has few treatment options. The initiation and progression of PH is associated with inflammation and inflammatory cell recruitment and it is established that hypoxia-induced mitogenic factor (HIMF, also known as resistin-like molecule α), activates macrophages in PH. However, the relationship between HIMF and inflammatory myoblasts remains unclear. This study investigated the signaling pathway involved in interleukin-18 (IL-18) expression and its relationship with HIMF in cultured myoblasts. We found that HIMF increased IL-18 production in myoblasts and that secreted IL-18 promoted tube formation of the endothelial progenitor cells. We used the mouse xenograft model and the chick chorioallantoic membrane assay to further explore the role of HIMF in inflammatory myoblasts and angiogenesis in vivo. Thus, our study focused on the mechanism by which HIMF mediates IL-18 expression in myoblasts through angiogenesis in vitro and in vivo. Our findings provide an insight into HIMF functioning in inflammatory myoblasts.
format	article
author	Chen-Ming Su I-Ching Wang Shan-Chi Liu Yi Sun Lulu Jin Shih-Wei Wang Hsiang-Ping Lee Wen-Pei Tseng Chih-Hsin Tang
author_facet	Chen-Ming Su I-Ching Wang Shan-Chi Liu Yi Sun Lulu Jin Shih-Wei Wang Hsiang-Ping Lee Wen-Pei Tseng Chih-Hsin Tang
author_sort	Chen-Ming Su
title	Hypoxia induced mitogenic factor (HIMF) triggers angiogenesis by increasing interleukin-18 production in myoblasts
title_short	Hypoxia induced mitogenic factor (HIMF) triggers angiogenesis by increasing interleukin-18 production in myoblasts
title_full	Hypoxia induced mitogenic factor (HIMF) triggers angiogenesis by increasing interleukin-18 production in myoblasts
title_fullStr	Hypoxia induced mitogenic factor (HIMF) triggers angiogenesis by increasing interleukin-18 production in myoblasts
title_full_unstemmed	Hypoxia induced mitogenic factor (HIMF) triggers angiogenesis by increasing interleukin-18 production in myoblasts
title_sort	hypoxia induced mitogenic factor (himf) triggers angiogenesis by increasing interleukin-18 production in myoblasts
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8d860b455da44fc887ad37bf0be8e6b8
work_keys_str_mv	AT chenmingsu hypoxiainducedmitogenicfactorhimftriggersangiogenesisbyincreasinginterleukin18productioninmyoblasts AT ichingwang hypoxiainducedmitogenicfactorhimftriggersangiogenesisbyincreasinginterleukin18productioninmyoblasts AT shanchiliu hypoxiainducedmitogenicfactorhimftriggersangiogenesisbyincreasinginterleukin18productioninmyoblasts AT yisun hypoxiainducedmitogenicfactorhimftriggersangiogenesisbyincreasinginterleukin18productioninmyoblasts AT lulujin hypoxiainducedmitogenicfactorhimftriggersangiogenesisbyincreasinginterleukin18productioninmyoblasts AT shihweiwang hypoxiainducedmitogenicfactorhimftriggersangiogenesisbyincreasinginterleukin18productioninmyoblasts AT hsiangpinglee hypoxiainducedmitogenicfactorhimftriggersangiogenesisbyincreasinginterleukin18productioninmyoblasts AT wenpeitseng hypoxiainducedmitogenicfactorhimftriggersangiogenesisbyincreasinginterleukin18productioninmyoblasts AT chihhsintang hypoxiainducedmitogenicfactorhimftriggersangiogenesisbyincreasinginterleukin18productioninmyoblasts
_version_	1718384854460006400

Hypoxia induced mitogenic factor (HIMF) triggers angiogenesis by increasing interleukin-18 production in myoblasts

Ejemplares similares