Diabetic corneal neuropathy: clinical perspectives

Guzel Bikbova,1,2 Toshiyuki Oshitari,1 Takayuki Baba,1 Mukharram Bikbov,2 Shuichi Yamamoto1 1Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba, Japan; 2Cornea and Refractive Surgery Department, Ufa Eye Research Institute, Ufa, Russia Abstract: Diab...

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Autores principales:	Bikbova G, Oshitari T, Baba T, Bikbov M, Yamamoto S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	diabetes mellitus cornea innervation neuroprotective therapy Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/8d8c74f7cfd1488ab11554d28184529d
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spelling	oai:doaj.org-article:8d8c74f7cfd1488ab11554d28184529d2021-12-02T08:32:31ZDiabetic corneal neuropathy: clinical perspectives1177-5483https://doaj.org/article/8d8c74f7cfd1488ab11554d28184529d2018-05-01T00:00:00Zhttps://www.dovepress.com/diabetic-corneal-neuropathy-clinical-perspectives-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Guzel Bikbova,1,2 Toshiyuki Oshitari,1 Takayuki Baba,1 Mukharram Bikbov,2 Shuichi Yamamoto1 1Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba, Japan; 2Cornea and Refractive Surgery Department, Ufa Eye Research Institute, Ufa, Russia Abstract: Diabetic keratopathy is characterized by impaired innervation of the cornea that leads to decreased sensitivity, with resultant difficulties with epithelial wound healing. These difficulties in wound healing put patients at risk for ocular complications such as surface irregularities, corneal infections, and stromal opacification. Pathological changes in corneal innervations in diabetic patients are an important early indicator of diabetic neuropathy. The decrease in corneal sensitivity is strongly correlated with the duration of diabetes as well as the severity of the neuropathy. This review presents recent findings in assessing the ocular surface as well as the recent therapeutic strategies for optimal management of individuals with diabetes who are susceptible to developing diabetic neuropathy. Keywords: diabetes mellitus, cornea, innervation, neuroprotective therapyBikbova GOshitari TBaba TBikbov MYamamoto SDove Medical Pressarticlediabetes mellituscorneainnervationneuroprotective therapyOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 981-987 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetes mellitus cornea innervation neuroprotective therapy Ophthalmology RE1-994
spellingShingle	diabetes mellitus cornea innervation neuroprotective therapy Ophthalmology RE1-994 Bikbova G Oshitari T Baba T Bikbov M Yamamoto S Diabetic corneal neuropathy: clinical perspectives
description	Guzel Bikbova,1,2 Toshiyuki Oshitari,1 Takayuki Baba,1 Mukharram Bikbov,2 Shuichi Yamamoto1 1Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba, Japan; 2Cornea and Refractive Surgery Department, Ufa Eye Research Institute, Ufa, Russia Abstract: Diabetic keratopathy is characterized by impaired innervation of the cornea that leads to decreased sensitivity, with resultant difficulties with epithelial wound healing. These difficulties in wound healing put patients at risk for ocular complications such as surface irregularities, corneal infections, and stromal opacification. Pathological changes in corneal innervations in diabetic patients are an important early indicator of diabetic neuropathy. The decrease in corneal sensitivity is strongly correlated with the duration of diabetes as well as the severity of the neuropathy. This review presents recent findings in assessing the ocular surface as well as the recent therapeutic strategies for optimal management of individuals with diabetes who are susceptible to developing diabetic neuropathy. Keywords: diabetes mellitus, cornea, innervation, neuroprotective therapy
format	article
author	Bikbova G Oshitari T Baba T Bikbov M Yamamoto S
author_facet	Bikbova G Oshitari T Baba T Bikbov M Yamamoto S
author_sort	Bikbova G
title	Diabetic corneal neuropathy: clinical perspectives
title_short	Diabetic corneal neuropathy: clinical perspectives
title_full	Diabetic corneal neuropathy: clinical perspectives
title_fullStr	Diabetic corneal neuropathy: clinical perspectives
title_full_unstemmed	Diabetic corneal neuropathy: clinical perspectives
title_sort	diabetic corneal neuropathy: clinical perspectives
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/8d8c74f7cfd1488ab11554d28184529d
work_keys_str_mv	AT bikbovag diabeticcornealneuropathyclinicalperspectives AT oshitarit diabeticcornealneuropathyclinicalperspectives AT babat diabeticcornealneuropathyclinicalperspectives AT bikbovm diabeticcornealneuropathyclinicalperspectives AT yamamotos diabeticcornealneuropathyclinicalperspectives
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Diabetic corneal neuropathy: clinical perspectives

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