Abnormal resting-state functional connectivity within the default mode network subregions in male patients with obstructive sleep apnea

Hai-Jun Li,1 Xiao Nie,1 Hong-Han Gong,1 Wei Zhang,2 Si Nie,1 De-Chang Peng11Department of Radiology, 2Department of Pneumology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, People’s Republic of ChinaBackground and objective: Abnormal resting-state funct...

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Autores principales:	Li HJ, Nie X, Gong HH, Zhang W, Nie S, Peng DC
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Obstructive sleep apnea Functional connectivity Default mode network functional MRI Cognitive impairment Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/8d8d8c80aa9042109b07f36fd8aaa674
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spelling	oai:doaj.org-article:8d8d8c80aa9042109b07f36fd8aaa6742021-12-02T07:17:03ZAbnormal resting-state functional connectivity within the default mode network subregions in male patients with obstructive sleep apnea1178-2021https://doaj.org/article/8d8d8c80aa9042109b07f36fd8aaa6742016-01-01T00:00:00Zhttps://www.dovepress.com/abnormal-resting-state-functional-connectivity-within-the-default-mode-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Hai-Jun Li,1 Xiao Nie,1 Hong-Han Gong,1 Wei Zhang,2 Si Nie,1 De-Chang Peng11Department of Radiology, 2Department of Pneumology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, People’s Republic of ChinaBackground and objective: Abnormal resting-state functional connectivity (rs-FC) between the central executive network and the default mode network (DMN) in patients with obstructive sleep apnea (OSA) has been reported. However, the effect of OSA on rs-FC within the DMN subregions remains uncertain. This study was designed to investigate whether the rs-FC within the DMN subregions was disrupted and determine its relationship with clinical symptoms in patients with OSA. Methods: Forty male patients newly diagnosed with severe OSA and 40 male education- and age-matched good sleepers (GSs) underwent functional magnetic resonance imaging (fMRI) examinations and clinical and neuropsychologic assessments. Seed-based region of interest rs-FC method was used to analyze the connectivity between each pair of subregions within the DMN, including the medial prefrontal cortex (MPFC), posterior cingulate cortex (PCC), hippocampus formation (HF), inferior parietal cortices (IPC), and medial temporal lobe (MTL). The abnormal rs-FC strength within the DMN subregions was correlated with clinical and neuropsychologic assessments using Pearson correlation analysis in patients with OSA. Results: Compared with GSs, patients with OSA had significantly decreased rs-FC between the right HF and the PCC, MPFC, and left MTL. However, patients with OSA had significantly increased rs-FC between the MPFC and left and right IPC, and between the left IPC and right IPC. The rs-FC between the right HF and left MTL was positively correlated with rapid eye movement (r=0.335, P=0.035). The rs-FC between the PCC and right HF was negatively correlated with delayed memory (r=-0.338, P=0.033).Conclusion: OSA selectively impairs the rs-FC between right HF and PCC, MPFC, and left MTL within the DMN subregions, and provides an imaging indicator for assessment of cognitive dysfunction in OSA patients. Keywords: obstructive sleep apnea, functional connectivity, default mode network, functional MRI, cognitive impairmentLi HJNie XGong HHZhang WNie SPeng DCDove Medical PressarticleObstructive sleep apneaFunctional connectivityDefault mode networkfunctional MRICognitive impairmentNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2016, Iss Issue 1, Pp 203-212 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Obstructive sleep apnea Functional connectivity Default mode network functional MRI Cognitive impairment Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Obstructive sleep apnea Functional connectivity Default mode network functional MRI Cognitive impairment Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Li HJ Nie X Gong HH Zhang W Nie S Peng DC Abnormal resting-state functional connectivity within the default mode network subregions in male patients with obstructive sleep apnea
description	Hai-Jun Li,1 Xiao Nie,1 Hong-Han Gong,1 Wei Zhang,2 Si Nie,1 De-Chang Peng11Department of Radiology, 2Department of Pneumology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, People’s Republic of ChinaBackground and objective: Abnormal resting-state functional connectivity (rs-FC) between the central executive network and the default mode network (DMN) in patients with obstructive sleep apnea (OSA) has been reported. However, the effect of OSA on rs-FC within the DMN subregions remains uncertain. This study was designed to investigate whether the rs-FC within the DMN subregions was disrupted and determine its relationship with clinical symptoms in patients with OSA. Methods: Forty male patients newly diagnosed with severe OSA and 40 male education- and age-matched good sleepers (GSs) underwent functional magnetic resonance imaging (fMRI) examinations and clinical and neuropsychologic assessments. Seed-based region of interest rs-FC method was used to analyze the connectivity between each pair of subregions within the DMN, including the medial prefrontal cortex (MPFC), posterior cingulate cortex (PCC), hippocampus formation (HF), inferior parietal cortices (IPC), and medial temporal lobe (MTL). The abnormal rs-FC strength within the DMN subregions was correlated with clinical and neuropsychologic assessments using Pearson correlation analysis in patients with OSA. Results: Compared with GSs, patients with OSA had significantly decreased rs-FC between the right HF and the PCC, MPFC, and left MTL. However, patients with OSA had significantly increased rs-FC between the MPFC and left and right IPC, and between the left IPC and right IPC. The rs-FC between the right HF and left MTL was positively correlated with rapid eye movement (r=0.335, P=0.035). The rs-FC between the PCC and right HF was negatively correlated with delayed memory (r=-0.338, P=0.033).Conclusion: OSA selectively impairs the rs-FC between right HF and PCC, MPFC, and left MTL within the DMN subregions, and provides an imaging indicator for assessment of cognitive dysfunction in OSA patients. Keywords: obstructive sleep apnea, functional connectivity, default mode network, functional MRI, cognitive impairment
format	article
author	Li HJ Nie X Gong HH Zhang W Nie S Peng DC
author_facet	Li HJ Nie X Gong HH Zhang W Nie S Peng DC
author_sort	Li HJ
title	Abnormal resting-state functional connectivity within the default mode network subregions in male patients with obstructive sleep apnea
title_short	Abnormal resting-state functional connectivity within the default mode network subregions in male patients with obstructive sleep apnea
title_full	Abnormal resting-state functional connectivity within the default mode network subregions in male patients with obstructive sleep apnea
title_fullStr	Abnormal resting-state functional connectivity within the default mode network subregions in male patients with obstructive sleep apnea
title_full_unstemmed	Abnormal resting-state functional connectivity within the default mode network subregions in male patients with obstructive sleep apnea
title_sort	abnormal resting-state functional connectivity within the default mode network subregions in male patients with obstructive sleep apnea
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/8d8d8c80aa9042109b07f36fd8aaa674
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Abnormal resting-state functional connectivity within the default mode network subregions in male patients with obstructive sleep apnea

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