Germline BRCA2 mutations drive prostate cancers with distinct evolutionary trajectories

Men that carrierBRCA2germline mutations are at risk of developing prostate cancer. Here, the authors analyse the genomes of prostate cancer from these individuals and demonstrate increased genomic instability in comparison to sporadic prostate cancer.

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Autores principales:	Renea A. Taylor, Michael Fraser, Julie Livingstone, Shadrielle Melijah G. Espiritu, Heather Thorne, Vincent Huang, Winnie Lo, Yu-Jia Shiah, Takafumi N. Yamaguchi, Ania Sliwinski, Sheri Horsburgh, Alice Meng, Lawrence E. Heisler, Nancy Yu, Fouad Yousif, Melissa Papargiris, Mitchell G. Lawrence, Lee Timms, Declan G. Murphy, Mark Frydenberg, Julia F. Hopkins, Damien Bolton, David Clouston, John D. McPherson, Theodorus van der Kwast, Paul C. Boutros, Gail P. Risbridger, Robert G. Bristow
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8d920a8293a04405b9542b7f3b199b5c
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spelling	oai:doaj.org-article:8d920a8293a04405b9542b7f3b199b5c2021-12-02T14:42:10ZGermline BRCA2 mutations drive prostate cancers with distinct evolutionary trajectories10.1038/ncomms136712041-1723https://doaj.org/article/8d920a8293a04405b9542b7f3b199b5c2017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms13671https://doaj.org/toc/2041-1723Men that carrierBRCA2germline mutations are at risk of developing prostate cancer. Here, the authors analyse the genomes of prostate cancer from these individuals and demonstrate increased genomic instability in comparison to sporadic prostate cancer.Renea A. TaylorMichael FraserJulie LivingstoneShadrielle Melijah G. EspirituHeather ThorneVincent HuangWinnie LoYu-Jia ShiahTakafumi N. YamaguchiAnia SliwinskiSheri HorsburghAlice MengLawrence E. HeislerNancy YuFouad YousifMelissa PapargirisMitchell G. LawrenceLee TimmsDeclan G. MurphyMark FrydenbergJulia F. HopkinsDamien BoltonDavid CloustonJohn D. McPhersonTheodorus van der KwastPaul C. BoutrosGail P. RisbridgerRobert G. BristowNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Renea A. Taylor Michael Fraser Julie Livingstone Shadrielle Melijah G. Espiritu Heather Thorne Vincent Huang Winnie Lo Yu-Jia Shiah Takafumi N. Yamaguchi Ania Sliwinski Sheri Horsburgh Alice Meng Lawrence E. Heisler Nancy Yu Fouad Yousif Melissa Papargiris Mitchell G. Lawrence Lee Timms Declan G. Murphy Mark Frydenberg Julia F. Hopkins Damien Bolton David Clouston John D. McPherson Theodorus van der Kwast Paul C. Boutros Gail P. Risbridger Robert G. Bristow Germline BRCA2 mutations drive prostate cancers with distinct evolutionary trajectories
description	Men that carrierBRCA2germline mutations are at risk of developing prostate cancer. Here, the authors analyse the genomes of prostate cancer from these individuals and demonstrate increased genomic instability in comparison to sporadic prostate cancer.
format	article
author	Renea A. Taylor Michael Fraser Julie Livingstone Shadrielle Melijah G. Espiritu Heather Thorne Vincent Huang Winnie Lo Yu-Jia Shiah Takafumi N. Yamaguchi Ania Sliwinski Sheri Horsburgh Alice Meng Lawrence E. Heisler Nancy Yu Fouad Yousif Melissa Papargiris Mitchell G. Lawrence Lee Timms Declan G. Murphy Mark Frydenberg Julia F. Hopkins Damien Bolton David Clouston John D. McPherson Theodorus van der Kwast Paul C. Boutros Gail P. Risbridger Robert G. Bristow
author_facet	Renea A. Taylor Michael Fraser Julie Livingstone Shadrielle Melijah G. Espiritu Heather Thorne Vincent Huang Winnie Lo Yu-Jia Shiah Takafumi N. Yamaguchi Ania Sliwinski Sheri Horsburgh Alice Meng Lawrence E. Heisler Nancy Yu Fouad Yousif Melissa Papargiris Mitchell G. Lawrence Lee Timms Declan G. Murphy Mark Frydenberg Julia F. Hopkins Damien Bolton David Clouston John D. McPherson Theodorus van der Kwast Paul C. Boutros Gail P. Risbridger Robert G. Bristow
author_sort	Renea A. Taylor
title	Germline BRCA2 mutations drive prostate cancers with distinct evolutionary trajectories
title_short	Germline BRCA2 mutations drive prostate cancers with distinct evolutionary trajectories
title_full	Germline BRCA2 mutations drive prostate cancers with distinct evolutionary trajectories
title_fullStr	Germline BRCA2 mutations drive prostate cancers with distinct evolutionary trajectories
title_full_unstemmed	Germline BRCA2 mutations drive prostate cancers with distinct evolutionary trajectories
title_sort	germline brca2 mutations drive prostate cancers with distinct evolutionary trajectories
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8d920a8293a04405b9542b7f3b199b5c
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Germline BRCA2 mutations drive prostate cancers with distinct evolutionary trajectories

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