Chlorpromazine eliminates acute myeloid leukemia cells by perturbing subcellular localization of FLT3-ITD and KIT-D816V

Receptor tyrosine kinase mutations are frequent and associated with poor prognosis in acute myeloid leukemia (AML). Here the authors show that the antipsychotic drug chlorpromazine reduces AML cells viability by perturbing the intracellular localization of FLT3-ITD and KIT-D816V.

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Autores principales:	Shinya Rai, Hirokazu Tanaka, Mai Suzuki, J. Luis Espinoza, Takahiro Kumode, Akira Tanimura, Takafumi Yokota, Kenji Oritani, Toshio Watanabe, Yuzuru Kanakura, Itaru Matsumura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8d959de3d6524e5897ad361f125459c1
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spelling	oai:doaj.org-article:8d959de3d6524e5897ad361f125459c12021-12-02T15:10:55ZChlorpromazine eliminates acute myeloid leukemia cells by perturbing subcellular localization of FLT3-ITD and KIT-D816V10.1038/s41467-020-17666-82041-1723https://doaj.org/article/8d959de3d6524e5897ad361f125459c12020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17666-8https://doaj.org/toc/2041-1723Receptor tyrosine kinase mutations are frequent and associated with poor prognosis in acute myeloid leukemia (AML). Here the authors show that the antipsychotic drug chlorpromazine reduces AML cells viability by perturbing the intracellular localization of FLT3-ITD and KIT-D816V.Shinya RaiHirokazu TanakaMai SuzukiJ. Luis EspinozaTakahiro KumodeAkira TanimuraTakafumi YokotaKenji OritaniToshio WatanabeYuzuru KanakuraItaru MatsumuraNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shinya Rai Hirokazu Tanaka Mai Suzuki J. Luis Espinoza Takahiro Kumode Akira Tanimura Takafumi Yokota Kenji Oritani Toshio Watanabe Yuzuru Kanakura Itaru Matsumura Chlorpromazine eliminates acute myeloid leukemia cells by perturbing subcellular localization of FLT3-ITD and KIT-D816V
description	Receptor tyrosine kinase mutations are frequent and associated with poor prognosis in acute myeloid leukemia (AML). Here the authors show that the antipsychotic drug chlorpromazine reduces AML cells viability by perturbing the intracellular localization of FLT3-ITD and KIT-D816V.
format	article
author	Shinya Rai Hirokazu Tanaka Mai Suzuki J. Luis Espinoza Takahiro Kumode Akira Tanimura Takafumi Yokota Kenji Oritani Toshio Watanabe Yuzuru Kanakura Itaru Matsumura
author_facet	Shinya Rai Hirokazu Tanaka Mai Suzuki J. Luis Espinoza Takahiro Kumode Akira Tanimura Takafumi Yokota Kenji Oritani Toshio Watanabe Yuzuru Kanakura Itaru Matsumura
author_sort	Shinya Rai
title	Chlorpromazine eliminates acute myeloid leukemia cells by perturbing subcellular localization of FLT3-ITD and KIT-D816V
title_short	Chlorpromazine eliminates acute myeloid leukemia cells by perturbing subcellular localization of FLT3-ITD and KIT-D816V
title_full	Chlorpromazine eliminates acute myeloid leukemia cells by perturbing subcellular localization of FLT3-ITD and KIT-D816V
title_fullStr	Chlorpromazine eliminates acute myeloid leukemia cells by perturbing subcellular localization of FLT3-ITD and KIT-D816V
title_full_unstemmed	Chlorpromazine eliminates acute myeloid leukemia cells by perturbing subcellular localization of FLT3-ITD and KIT-D816V
title_sort	chlorpromazine eliminates acute myeloid leukemia cells by perturbing subcellular localization of flt3-itd and kit-d816v
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8d959de3d6524e5897ad361f125459c1
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Chlorpromazine eliminates acute myeloid leukemia cells by perturbing subcellular localization of FLT3-ITD and KIT-D816V

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