αv integrins on mesenchymal cells regulate skeletal and cardiac muscle fibrosis

The mechanisms underlying tissue fibrosis are unclear. The authors show that mesenchymal cells expressing PDGFRβ mediate fibrosis in skeletal muscle and heart via a mechanism involving αv integrin, and that inhibitors of αv integrins attenuate fibrotic responses in mice.

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Autores principales:	I. R. Murray, Z. N. Gonzalez, J. Baily, R. Dobie, R. J. Wallace, A. C. Mackinnon, J. R. Smith, S. N. Greenhalgh, A. I. Thompson, K. P. Conroy, D. W. Griggs, P. G. Ruminski, G. A. Gray, M. Singh, M. A. Campbell, T. J. Kendall, J. Dai, Y. Li, J. P. Iredale, H. Simpson, J. Huard, B. Péault, N. C. Henderson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8d98304aaf1746329d6b32e5bc823995
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:8d98304aaf1746329d6b32e5bc8239952021-12-02T17:06:14Zαv integrins on mesenchymal cells regulate skeletal and cardiac muscle fibrosis10.1038/s41467-017-01097-z2041-1723https://doaj.org/article/8d98304aaf1746329d6b32e5bc8239952017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01097-zhttps://doaj.org/toc/2041-1723The mechanisms underlying tissue fibrosis are unclear. The authors show that mesenchymal cells expressing PDGFRβ mediate fibrosis in skeletal muscle and heart via a mechanism involving αv integrin, and that inhibitors of αv integrins attenuate fibrotic responses in mice.I. R. MurrayZ. N. GonzalezJ. BailyR. DobieR. J. WallaceA. C. MackinnonJ. R. SmithS. N. GreenhalghA. I. ThompsonK. P. ConroyD. W. GriggsP. G. RuminskiG. A. GrayM. SinghM. A. CampbellT. J. KendallJ. DaiY. LiJ. P. IredaleH. SimpsonJ. HuardB. PéaultN. C. HendersonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q I. R. Murray Z. N. Gonzalez J. Baily R. Dobie R. J. Wallace A. C. Mackinnon J. R. Smith S. N. Greenhalgh A. I. Thompson K. P. Conroy D. W. Griggs P. G. Ruminski G. A. Gray M. Singh M. A. Campbell T. J. Kendall J. Dai Y. Li J. P. Iredale H. Simpson J. Huard B. Péault N. C. Henderson αv integrins on mesenchymal cells regulate skeletal and cardiac muscle fibrosis
description	The mechanisms underlying tissue fibrosis are unclear. The authors show that mesenchymal cells expressing PDGFRβ mediate fibrosis in skeletal muscle and heart via a mechanism involving αv integrin, and that inhibitors of αv integrins attenuate fibrotic responses in mice.
format	article
author	I. R. Murray Z. N. Gonzalez J. Baily R. Dobie R. J. Wallace A. C. Mackinnon J. R. Smith S. N. Greenhalgh A. I. Thompson K. P. Conroy D. W. Griggs P. G. Ruminski G. A. Gray M. Singh M. A. Campbell T. J. Kendall J. Dai Y. Li J. P. Iredale H. Simpson J. Huard B. Péault N. C. Henderson
author_facet	I. R. Murray Z. N. Gonzalez J. Baily R. Dobie R. J. Wallace A. C. Mackinnon J. R. Smith S. N. Greenhalgh A. I. Thompson K. P. Conroy D. W. Griggs P. G. Ruminski G. A. Gray M. Singh M. A. Campbell T. J. Kendall J. Dai Y. Li J. P. Iredale H. Simpson J. Huard B. Péault N. C. Henderson
author_sort	I. R. Murray
title	αv integrins on mesenchymal cells regulate skeletal and cardiac muscle fibrosis
title_short	αv integrins on mesenchymal cells regulate skeletal and cardiac muscle fibrosis
title_full	αv integrins on mesenchymal cells regulate skeletal and cardiac muscle fibrosis
title_fullStr	αv integrins on mesenchymal cells regulate skeletal and cardiac muscle fibrosis
title_full_unstemmed	αv integrins on mesenchymal cells regulate skeletal and cardiac muscle fibrosis
title_sort	αv integrins on mesenchymal cells regulate skeletal and cardiac muscle fibrosis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8d98304aaf1746329d6b32e5bc823995
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αv integrins on mesenchymal cells regulate skeletal and cardiac muscle fibrosis

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