Tumour-associated macrophages exhibit anti-tumoural properties in Sonic Hedgehog medulloblastoma

The Sonic Hedgehog subgroup of medulloblastoma are characterised by the high infiltration of tumour-associated macrophages (TAMs). Here, the authors show that TAM numbers in patients are associated with better prognosis and that, consistently, in a murine model of medulloblastoma, these TAMs have an...

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Autores principales:	Victor Maximov, Zhihong Chen, Yun Wei, M. Hope Robinson, Cameron J. Herting, Nithya S. Shanmugam, Vasilisa A. Rudneva, Kelly C. Goldsmith, Tobey J. MacDonald, Paul A. Northcott, Dolores Hambardzumyan, Anna M. Kenney
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8d9bcf366d79419c9f9e965c3c18cd6f
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spelling	oai:doaj.org-article:8d9bcf366d79419c9f9e965c3c18cd6f2021-12-02T17:01:26ZTumour-associated macrophages exhibit anti-tumoural properties in Sonic Hedgehog medulloblastoma10.1038/s41467-019-10458-92041-1723https://doaj.org/article/8d9bcf366d79419c9f9e965c3c18cd6f2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10458-9https://doaj.org/toc/2041-1723The Sonic Hedgehog subgroup of medulloblastoma are characterised by the high infiltration of tumour-associated macrophages (TAMs). Here, the authors show that TAM numbers in patients are associated with better prognosis and that, consistently, in a murine model of medulloblastoma, these TAMs have anti-tumoural properties.Victor MaximovZhihong ChenYun WeiM. Hope RobinsonCameron J. HertingNithya S. ShanmugamVasilisa A. RudnevaKelly C. GoldsmithTobey J. MacDonaldPaul A. NorthcottDolores HambardzumyanAnna M. KenneyNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Victor Maximov Zhihong Chen Yun Wei M. Hope Robinson Cameron J. Herting Nithya S. Shanmugam Vasilisa A. Rudneva Kelly C. Goldsmith Tobey J. MacDonald Paul A. Northcott Dolores Hambardzumyan Anna M. Kenney Tumour-associated macrophages exhibit anti-tumoural properties in Sonic Hedgehog medulloblastoma
description	The Sonic Hedgehog subgroup of medulloblastoma are characterised by the high infiltration of tumour-associated macrophages (TAMs). Here, the authors show that TAM numbers in patients are associated with better prognosis and that, consistently, in a murine model of medulloblastoma, these TAMs have anti-tumoural properties.
format	article
author	Victor Maximov Zhihong Chen Yun Wei M. Hope Robinson Cameron J. Herting Nithya S. Shanmugam Vasilisa A. Rudneva Kelly C. Goldsmith Tobey J. MacDonald Paul A. Northcott Dolores Hambardzumyan Anna M. Kenney
author_facet	Victor Maximov Zhihong Chen Yun Wei M. Hope Robinson Cameron J. Herting Nithya S. Shanmugam Vasilisa A. Rudneva Kelly C. Goldsmith Tobey J. MacDonald Paul A. Northcott Dolores Hambardzumyan Anna M. Kenney
author_sort	Victor Maximov
title	Tumour-associated macrophages exhibit anti-tumoural properties in Sonic Hedgehog medulloblastoma
title_short	Tumour-associated macrophages exhibit anti-tumoural properties in Sonic Hedgehog medulloblastoma
title_full	Tumour-associated macrophages exhibit anti-tumoural properties in Sonic Hedgehog medulloblastoma
title_fullStr	Tumour-associated macrophages exhibit anti-tumoural properties in Sonic Hedgehog medulloblastoma
title_full_unstemmed	Tumour-associated macrophages exhibit anti-tumoural properties in Sonic Hedgehog medulloblastoma
title_sort	tumour-associated macrophages exhibit anti-tumoural properties in sonic hedgehog medulloblastoma
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/8d9bcf366d79419c9f9e965c3c18cd6f
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Tumour-associated macrophages exhibit anti-tumoural properties in Sonic Hedgehog medulloblastoma

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