Analysis of Common Pathways and Markers From Non-Alcoholic Fatty Liver Disease to Immune-Mediated Diseases
Metabolic associated fatty liver disease (MAFLD) is the most prevalent form of liver disease worldwide, accounting for a high liver-related mortality and morbidity with extensive multi-organ involvement. This entity has displaced viral hepatitis as the main cause of severe forms of hepatic diseases,...
Guardado en:
| Autores principales: | , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Frontiers Media S.A.
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/8d9c6696eb054d378c7a6d45a6dbe999 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:8d9c6696eb054d378c7a6d45a6dbe999 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:8d9c6696eb054d378c7a6d45a6dbe9992021-11-30T18:54:52ZAnalysis of Common Pathways and Markers From Non-Alcoholic Fatty Liver Disease to Immune-Mediated Diseases1664-322410.3389/fimmu.2021.667354https://doaj.org/article/8d9c6696eb054d378c7a6d45a6dbe9992021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.667354/fullhttps://doaj.org/toc/1664-3224Metabolic associated fatty liver disease (MAFLD) is the most prevalent form of liver disease worldwide, accounting for a high liver-related mortality and morbidity with extensive multi-organ involvement. This entity has displaced viral hepatitis as the main cause of severe forms of hepatic diseases, although the onset and transition of MAFLD stages still remains unclear. Nevertheless, innate and adaptive immune responses seem to play an essential role in the establishment and further progression of this disease. The immune system is responsible of safeguard and preserves organs and systems function, and might be altered under different stimuli. Thus, the liver suffers from metabolic and immune changes leading to different injuries and loss of function. It has been stablished that cell-cell crosstalk is a key process in the hepatic homeostasis maintenance. There is mounting evidence suggesting that MAFLD pathogenesis is determined by a complex interaction of environmental, genetic and host factors that leads to a full plethora of outcomes. Therefore, herein we will revisit and discuss the interplay between immune mechanisms and MAFLD, highlighting the potential role of immunological markers in an attempt to clarify its relationship.Rocío Gallego-DuránRocío Gallego-DuránRocío Montero-VallejoRocío Montero-VallejoDouglas Maya-MilesDouglas Maya-MilesAna LucenaAna LucenaAna LucenaFranz MartinFranz MartinJavier AmpueroJavier AmpueroJavier AmpueroManuel Romero-GómezManuel Romero-GómezManuel Romero-GómezFrontiers Media S.A.articleNAFLDNASHimmunologyfibrosisbiomarkersImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
NAFLD NASH immunology fibrosis biomarkers Immunologic diseases. Allergy RC581-607 |
| spellingShingle |
NAFLD NASH immunology fibrosis biomarkers Immunologic diseases. Allergy RC581-607 Rocío Gallego-Durán Rocío Gallego-Durán Rocío Montero-Vallejo Rocío Montero-Vallejo Douglas Maya-Miles Douglas Maya-Miles Ana Lucena Ana Lucena Ana Lucena Franz Martin Franz Martin Javier Ampuero Javier Ampuero Javier Ampuero Manuel Romero-Gómez Manuel Romero-Gómez Manuel Romero-Gómez Analysis of Common Pathways and Markers From Non-Alcoholic Fatty Liver Disease to Immune-Mediated Diseases |
| description |
Metabolic associated fatty liver disease (MAFLD) is the most prevalent form of liver disease worldwide, accounting for a high liver-related mortality and morbidity with extensive multi-organ involvement. This entity has displaced viral hepatitis as the main cause of severe forms of hepatic diseases, although the onset and transition of MAFLD stages still remains unclear. Nevertheless, innate and adaptive immune responses seem to play an essential role in the establishment and further progression of this disease. The immune system is responsible of safeguard and preserves organs and systems function, and might be altered under different stimuli. Thus, the liver suffers from metabolic and immune changes leading to different injuries and loss of function. It has been stablished that cell-cell crosstalk is a key process in the hepatic homeostasis maintenance. There is mounting evidence suggesting that MAFLD pathogenesis is determined by a complex interaction of environmental, genetic and host factors that leads to a full plethora of outcomes. Therefore, herein we will revisit and discuss the interplay between immune mechanisms and MAFLD, highlighting the potential role of immunological markers in an attempt to clarify its relationship. |
| format |
article |
| author |
Rocío Gallego-Durán Rocío Gallego-Durán Rocío Montero-Vallejo Rocío Montero-Vallejo Douglas Maya-Miles Douglas Maya-Miles Ana Lucena Ana Lucena Ana Lucena Franz Martin Franz Martin Javier Ampuero Javier Ampuero Javier Ampuero Manuel Romero-Gómez Manuel Romero-Gómez Manuel Romero-Gómez |
| author_facet |
Rocío Gallego-Durán Rocío Gallego-Durán Rocío Montero-Vallejo Rocío Montero-Vallejo Douglas Maya-Miles Douglas Maya-Miles Ana Lucena Ana Lucena Ana Lucena Franz Martin Franz Martin Javier Ampuero Javier Ampuero Javier Ampuero Manuel Romero-Gómez Manuel Romero-Gómez Manuel Romero-Gómez |
| author_sort |
Rocío Gallego-Durán |
| title |
Analysis of Common Pathways and Markers From Non-Alcoholic Fatty Liver Disease to Immune-Mediated Diseases |
| title_short |
Analysis of Common Pathways and Markers From Non-Alcoholic Fatty Liver Disease to Immune-Mediated Diseases |
| title_full |
Analysis of Common Pathways and Markers From Non-Alcoholic Fatty Liver Disease to Immune-Mediated Diseases |
| title_fullStr |
Analysis of Common Pathways and Markers From Non-Alcoholic Fatty Liver Disease to Immune-Mediated Diseases |
| title_full_unstemmed |
Analysis of Common Pathways and Markers From Non-Alcoholic Fatty Liver Disease to Immune-Mediated Diseases |
| title_sort |
analysis of common pathways and markers from non-alcoholic fatty liver disease to immune-mediated diseases |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/8d9c6696eb054d378c7a6d45a6dbe999 |
| work_keys_str_mv |
AT rociogallegoduran analysisofcommonpathwaysandmarkersfromnonalcoholicfattyliverdiseasetoimmunemediateddiseases AT rociogallegoduran analysisofcommonpathwaysandmarkersfromnonalcoholicfattyliverdiseasetoimmunemediateddiseases AT rociomonterovallejo analysisofcommonpathwaysandmarkersfromnonalcoholicfattyliverdiseasetoimmunemediateddiseases AT rociomonterovallejo analysisofcommonpathwaysandmarkersfromnonalcoholicfattyliverdiseasetoimmunemediateddiseases AT douglasmayamiles analysisofcommonpathwaysandmarkersfromnonalcoholicfattyliverdiseasetoimmunemediateddiseases AT douglasmayamiles analysisofcommonpathwaysandmarkersfromnonalcoholicfattyliverdiseasetoimmunemediateddiseases AT analucena analysisofcommonpathwaysandmarkersfromnonalcoholicfattyliverdiseasetoimmunemediateddiseases AT analucena analysisofcommonpathwaysandmarkersfromnonalcoholicfattyliverdiseasetoimmunemediateddiseases AT analucena analysisofcommonpathwaysandmarkersfromnonalcoholicfattyliverdiseasetoimmunemediateddiseases AT franzmartin analysisofcommonpathwaysandmarkersfromnonalcoholicfattyliverdiseasetoimmunemediateddiseases AT franzmartin analysisofcommonpathwaysandmarkersfromnonalcoholicfattyliverdiseasetoimmunemediateddiseases AT javierampuero analysisofcommonpathwaysandmarkersfromnonalcoholicfattyliverdiseasetoimmunemediateddiseases AT javierampuero analysisofcommonpathwaysandmarkersfromnonalcoholicfattyliverdiseasetoimmunemediateddiseases AT javierampuero analysisofcommonpathwaysandmarkersfromnonalcoholicfattyliverdiseasetoimmunemediateddiseases AT manuelromerogomez analysisofcommonpathwaysandmarkersfromnonalcoholicfattyliverdiseasetoimmunemediateddiseases AT manuelromerogomez analysisofcommonpathwaysandmarkersfromnonalcoholicfattyliverdiseasetoimmunemediateddiseases AT manuelromerogomez analysisofcommonpathwaysandmarkersfromnonalcoholicfattyliverdiseasetoimmunemediateddiseases |
| _version_ |
1718406339429924864 |