The burden attributable to mental and substance use disorders as risk factors for suicide: findings from the Global Burden of Disease Study 2010.

<h4>Background</h4>The Global Burden of Disease Study 2010 (GBD 2010) identified mental and substance use disorders as the 5th leading contributor of burden in 2010, measured by disability adjusted life years (DALYs). This estimate was incomplete as it excluded burden resulting from the...

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Autores principales:	Alize J Ferrari, Rosana E Norman, Greg Freedman, Amanda J Baxter, Jane E Pirkis, Meredith G Harris, Andrew Page, Emily Carnahan, Louisa Degenhardt, Theo Vos, Harvey A Whiteford
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8d9c93f0659c4facb2cf818cb5900238
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spelling	oai:doaj.org-article:8d9c93f0659c4facb2cf818cb59002382021-11-18T08:25:22ZThe burden attributable to mental and substance use disorders as risk factors for suicide: findings from the Global Burden of Disease Study 2010.1932-620310.1371/journal.pone.0091936https://doaj.org/article/8d9c93f0659c4facb2cf818cb59002382014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24694747/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The Global Burden of Disease Study 2010 (GBD 2010) identified mental and substance use disorders as the 5th leading contributor of burden in 2010, measured by disability adjusted life years (DALYs). This estimate was incomplete as it excluded burden resulting from the increased risk of suicide captured elsewhere in GBD 2010's mutually exclusive list of diseases and injuries. Here, we estimate suicide DALYs attributable to mental and substance use disorders.<h4>Methods</h4>Relative-risk estimates of suicide due to mental and substance use disorders and the global prevalence of each disorder were used to estimate population attributable fractions. These were adjusted for global differences in the proportion of suicide due to mental and substance use disorders compared to other causes then multiplied by suicide DALYs reported in GBD 2010 to estimate attributable DALYs (with 95% uncertainty).<h4>Results</h4>Mental and substance use disorders were responsible for 22.5 million (14.8-29.8 million) of the 36.2 million (26.5-44.3 million) DALYs allocated to suicide in 2010. Depression was responsible for the largest proportion of suicide DALYs (46.1% (28.0%-60.8%)) and anorexia nervosa the lowest (0.2% (0.02%-0.5%)). DALYs occurred throughout the lifespan, with the largest proportion found in Eastern Europe and Asia, and males aged 20-30 years. The inclusion of attributable suicide DALYs would have increased the overall burden of mental and substance use disorders (assigned to them in GBD 2010 as a direct cause) from 7.4% (6.2%-8.6%) to 8.3% (7.1%-9.6%) of global DALYs, and would have changed the global ranking from 5th to 3rd leading cause of burden.<h4>Conclusions</h4>Capturing the suicide burden attributable to mental and substance use disorders allows for more accurate estimates of burden. More consideration needs to be given to interventions targeted to populations with, or at risk for, mental and substance use disorders as an effective strategy for suicide prevention.Alize J FerrariRosana E NormanGreg FreedmanAmanda J BaxterJane E PirkisMeredith G HarrisAndrew PageEmily CarnahanLouisa DegenhardtTheo VosHarvey A WhitefordPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 4, p e91936 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alize J Ferrari Rosana E Norman Greg Freedman Amanda J Baxter Jane E Pirkis Meredith G Harris Andrew Page Emily Carnahan Louisa Degenhardt Theo Vos Harvey A Whiteford The burden attributable to mental and substance use disorders as risk factors for suicide: findings from the Global Burden of Disease Study 2010.
description	<h4>Background</h4>The Global Burden of Disease Study 2010 (GBD 2010) identified mental and substance use disorders as the 5th leading contributor of burden in 2010, measured by disability adjusted life years (DALYs). This estimate was incomplete as it excluded burden resulting from the increased risk of suicide captured elsewhere in GBD 2010's mutually exclusive list of diseases and injuries. Here, we estimate suicide DALYs attributable to mental and substance use disorders.<h4>Methods</h4>Relative-risk estimates of suicide due to mental and substance use disorders and the global prevalence of each disorder were used to estimate population attributable fractions. These were adjusted for global differences in the proportion of suicide due to mental and substance use disorders compared to other causes then multiplied by suicide DALYs reported in GBD 2010 to estimate attributable DALYs (with 95% uncertainty).<h4>Results</h4>Mental and substance use disorders were responsible for 22.5 million (14.8-29.8 million) of the 36.2 million (26.5-44.3 million) DALYs allocated to suicide in 2010. Depression was responsible for the largest proportion of suicide DALYs (46.1% (28.0%-60.8%)) and anorexia nervosa the lowest (0.2% (0.02%-0.5%)). DALYs occurred throughout the lifespan, with the largest proportion found in Eastern Europe and Asia, and males aged 20-30 years. The inclusion of attributable suicide DALYs would have increased the overall burden of mental and substance use disorders (assigned to them in GBD 2010 as a direct cause) from 7.4% (6.2%-8.6%) to 8.3% (7.1%-9.6%) of global DALYs, and would have changed the global ranking from 5th to 3rd leading cause of burden.<h4>Conclusions</h4>Capturing the suicide burden attributable to mental and substance use disorders allows for more accurate estimates of burden. More consideration needs to be given to interventions targeted to populations with, or at risk for, mental and substance use disorders as an effective strategy for suicide prevention.
format	article
author	Alize J Ferrari Rosana E Norman Greg Freedman Amanda J Baxter Jane E Pirkis Meredith G Harris Andrew Page Emily Carnahan Louisa Degenhardt Theo Vos Harvey A Whiteford
author_facet	Alize J Ferrari Rosana E Norman Greg Freedman Amanda J Baxter Jane E Pirkis Meredith G Harris Andrew Page Emily Carnahan Louisa Degenhardt Theo Vos Harvey A Whiteford
author_sort	Alize J Ferrari
title	The burden attributable to mental and substance use disorders as risk factors for suicide: findings from the Global Burden of Disease Study 2010.
title_short	The burden attributable to mental and substance use disorders as risk factors for suicide: findings from the Global Burden of Disease Study 2010.
title_full	The burden attributable to mental and substance use disorders as risk factors for suicide: findings from the Global Burden of Disease Study 2010.
title_fullStr	The burden attributable to mental and substance use disorders as risk factors for suicide: findings from the Global Burden of Disease Study 2010.
title_full_unstemmed	The burden attributable to mental and substance use disorders as risk factors for suicide: findings from the Global Burden of Disease Study 2010.
title_sort	burden attributable to mental and substance use disorders as risk factors for suicide: findings from the global burden of disease study 2010.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/8d9c93f0659c4facb2cf818cb5900238
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The burden attributable to mental and substance use disorders as risk factors for suicide: findings from the Global Burden of Disease Study 2010.

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