Designed CXCR4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting
The development of specific anti-cytokine/chemokine therapeutic strategies for atherosclerotic disease is challenging. Here, the authors have designed a peptide-based ectodomain mimic of the chemokine receptor CXCR4 that selectively targets MIF but not CXCL12 and blocks experimental atherosclerosis...
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Nature Portfolio
2020
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oai:doaj.org-article:8d9c94b2adec4a06a56a819e022710e72021-12-02T10:48:19ZDesigned CXCR4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting10.1038/s41467-020-19764-z2041-1723https://doaj.org/article/8d9c94b2adec4a06a56a819e022710e72020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19764-zhttps://doaj.org/toc/2041-1723The development of specific anti-cytokine/chemokine therapeutic strategies for atherosclerotic disease is challenging. Here, the authors have designed a peptide-based ectodomain mimic of the chemokine receptor CXCR4 that selectively targets MIF but not CXCL12 and blocks experimental atherosclerosis in vivo.Christos KontosOmar El BounkariChristine KrammerDzmitry SinitskiKathleen HilleChunfang ZanGuangyao YanSijia WangYing GaoMarkus BrandhoferRemco T. A. MegensAdrian HoffmannJessica PauliYaw AsareSimona GerraPriscila BourilhonLin LengHans-Henning EcksteinWolfgang E. KempfJaroslav PelisekOzgun GokceLars MaegdefesselRichard BucalaMartin DichgansChristian WeberAphrodite KapurniotuJürgen BernhagenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020) |
| institution |
DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Christos Kontos Omar El Bounkari Christine Krammer Dzmitry Sinitski Kathleen Hille Chunfang Zan Guangyao Yan Sijia Wang Ying Gao Markus Brandhofer Remco T. A. Megens Adrian Hoffmann Jessica Pauli Yaw Asare Simona Gerra Priscila Bourilhon Lin Leng Hans-Henning Eckstein Wolfgang E. Kempf Jaroslav Pelisek Ozgun Gokce Lars Maegdefessel Richard Bucala Martin Dichgans Christian Weber Aphrodite Kapurniotu Jürgen Bernhagen Designed CXCR4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting |
| description |
The development of specific anti-cytokine/chemokine therapeutic strategies for atherosclerotic disease is challenging. Here, the authors have designed a peptide-based ectodomain mimic of the chemokine receptor CXCR4 that selectively targets MIF but not CXCL12 and blocks experimental atherosclerosis in vivo. |
| format |
article |
| author |
Christos Kontos Omar El Bounkari Christine Krammer Dzmitry Sinitski Kathleen Hille Chunfang Zan Guangyao Yan Sijia Wang Ying Gao Markus Brandhofer Remco T. A. Megens Adrian Hoffmann Jessica Pauli Yaw Asare Simona Gerra Priscila Bourilhon Lin Leng Hans-Henning Eckstein Wolfgang E. Kempf Jaroslav Pelisek Ozgun Gokce Lars Maegdefessel Richard Bucala Martin Dichgans Christian Weber Aphrodite Kapurniotu Jürgen Bernhagen |
| author_facet |
Christos Kontos Omar El Bounkari Christine Krammer Dzmitry Sinitski Kathleen Hille Chunfang Zan Guangyao Yan Sijia Wang Ying Gao Markus Brandhofer Remco T. A. Megens Adrian Hoffmann Jessica Pauli Yaw Asare Simona Gerra Priscila Bourilhon Lin Leng Hans-Henning Eckstein Wolfgang E. Kempf Jaroslav Pelisek Ozgun Gokce Lars Maegdefessel Richard Bucala Martin Dichgans Christian Weber Aphrodite Kapurniotu Jürgen Bernhagen |
| author_sort |
Christos Kontos |
| title |
Designed CXCR4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting |
| title_short |
Designed CXCR4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting |
| title_full |
Designed CXCR4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting |
| title_fullStr |
Designed CXCR4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting |
| title_full_unstemmed |
Designed CXCR4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting |
| title_sort |
designed cxcr4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/8d9c94b2adec4a06a56a819e022710e7 |
| work_keys_str_mv |
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