Medial prefrontal cortex (A32 and A25) projections in the common marmoset: a subcortical anterograde study

Abstract This study was aimed at establishing the subcorticals substrates of the cognitive and visceromotor circuits of the A32 and A25 cortices of the medial prefrontal cortex and their projections and interactions with subcortical complexes in the common marmoset monkey (Callithrix jacchus). The s...

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Autores principales:	Jorge Alexander Ríos-Flórez, Ruthnaldo R. M. Lima, Paulo Leonardo A. G. Morais, Helder Henrique Alves de Medeiros, Jeferson Souza Cavalcante, Expedito S. Nascimento Junior
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8d9d2709d2fa4f888abf0ec72cd72573
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spelling	oai:doaj.org-article:8d9d2709d2fa4f888abf0ec72cd725732021-12-02T15:33:11ZMedial prefrontal cortex (A32 and A25) projections in the common marmoset: a subcortical anterograde study10.1038/s41598-021-93819-z2045-2322https://doaj.org/article/8d9d2709d2fa4f888abf0ec72cd725732021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93819-zhttps://doaj.org/toc/2045-2322Abstract This study was aimed at establishing the subcorticals substrates of the cognitive and visceromotor circuits of the A32 and A25 cortices of the medial prefrontal cortex and their projections and interactions with subcortical complexes in the common marmoset monkey (Callithrix jacchus). The study was primarily restricted to the nuclei of the diencephalon and amygdala. The common marmoset is a neotropical primate of the new world, and the absence of telencephalic gyrus favors the mapping of neuronal fibers. The biotinylated dextran amine was employed as an anterograde tracer. There was an evident pattern of rostrocaudal distribution of fibers within the subcortical nuclei, with medial orientation. Considering this distribution, fibers originating from the A25 cortex were found to be more clustered in the diencephalon and amygdala than those originating in the A32 cortex. Most areas of the amygdala received fibers from both cortices. In the diencephalon, all regions received projections from the A32, while the A25 fibers were restricted to the thalamus, hypothalamus, and epithalamus at different densities. Precise deposits of neuronal tracers provided here may significantly contribute to expand our understanding of specific connectivity among the medial prefrontal cortex with limbic regions and diencephalic areas, key elements to the viscerocognitive process.Jorge Alexander Ríos-FlórezRuthnaldo R. M. LimaPaulo Leonardo A. G. MoraisHelder Henrique Alves de MedeirosJeferson Souza CavalcanteExpedito S. Nascimento JuniorNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jorge Alexander Ríos-Flórez Ruthnaldo R. M. Lima Paulo Leonardo A. G. Morais Helder Henrique Alves de Medeiros Jeferson Souza Cavalcante Expedito S. Nascimento Junior Medial prefrontal cortex (A32 and A25) projections in the common marmoset: a subcortical anterograde study
description	Abstract This study was aimed at establishing the subcorticals substrates of the cognitive and visceromotor circuits of the A32 and A25 cortices of the medial prefrontal cortex and their projections and interactions with subcortical complexes in the common marmoset monkey (Callithrix jacchus). The study was primarily restricted to the nuclei of the diencephalon and amygdala. The common marmoset is a neotropical primate of the new world, and the absence of telencephalic gyrus favors the mapping of neuronal fibers. The biotinylated dextran amine was employed as an anterograde tracer. There was an evident pattern of rostrocaudal distribution of fibers within the subcortical nuclei, with medial orientation. Considering this distribution, fibers originating from the A25 cortex were found to be more clustered in the diencephalon and amygdala than those originating in the A32 cortex. Most areas of the amygdala received fibers from both cortices. In the diencephalon, all regions received projections from the A32, while the A25 fibers were restricted to the thalamus, hypothalamus, and epithalamus at different densities. Precise deposits of neuronal tracers provided here may significantly contribute to expand our understanding of specific connectivity among the medial prefrontal cortex with limbic regions and diencephalic areas, key elements to the viscerocognitive process.
format	article
author	Jorge Alexander Ríos-Flórez Ruthnaldo R. M. Lima Paulo Leonardo A. G. Morais Helder Henrique Alves de Medeiros Jeferson Souza Cavalcante Expedito S. Nascimento Junior
author_facet	Jorge Alexander Ríos-Flórez Ruthnaldo R. M. Lima Paulo Leonardo A. G. Morais Helder Henrique Alves de Medeiros Jeferson Souza Cavalcante Expedito S. Nascimento Junior
author_sort	Jorge Alexander Ríos-Flórez
title	Medial prefrontal cortex (A32 and A25) projections in the common marmoset: a subcortical anterograde study
title_short	Medial prefrontal cortex (A32 and A25) projections in the common marmoset: a subcortical anterograde study
title_full	Medial prefrontal cortex (A32 and A25) projections in the common marmoset: a subcortical anterograde study
title_fullStr	Medial prefrontal cortex (A32 and A25) projections in the common marmoset: a subcortical anterograde study
title_full_unstemmed	Medial prefrontal cortex (A32 and A25) projections in the common marmoset: a subcortical anterograde study
title_sort	medial prefrontal cortex (a32 and a25) projections in the common marmoset: a subcortical anterograde study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8d9d2709d2fa4f888abf0ec72cd72573
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Medial prefrontal cortex (A32 and A25) projections in the common marmoset: a subcortical anterograde study

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