Inference and effects of barcode multiplets in droplet-based single-cell assays

It is assumed that single-cell analyses capture one barcode per cell. Here, the authors show that up to 21% of cell barcodes on the 10X Chromium scATAC-seq assay may be derived from barcode multiplets.

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Detalles Bibliográficos
Autores principales: Caleb A. Lareau, Sai Ma, Fabiana M. Duarte, Jason D. Buenrostro
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
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Acceso en línea:https://doaj.org/article/8d9d4ceede554e67a58633816a18d4ba
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Descripción
Sumario:It is assumed that single-cell analyses capture one barcode per cell. Here, the authors show that up to 21% of cell barcodes on the 10X Chromium scATAC-seq assay may be derived from barcode multiplets.