Enhanced bioavailability of apigenin via preparation of a carbon nanopowder solid dispersion

Shu-min Ding,1–3 Zhen-hai Zhang,1,3 Jie Song,1,3 Xu-dong Cheng,1,3 Jun Jiang,1,3 Xiao-bin Jia1,31Affiliated Hospital on Integration of Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China; 2School of Pharmaceutical Engineering a...

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Autores principales:	Ding SM, Zhang ZH, Song J, Cheng XD, Jiang J, Jia XB
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8d9eba1f51764d21af3f87afbc96ee26
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spelling	oai:doaj.org-article:8d9eba1f51764d21af3f87afbc96ee262021-12-02T04:28:15ZEnhanced bioavailability of apigenin via preparation of a carbon nanopowder solid dispersion1178-2013https://doaj.org/article/8d9eba1f51764d21af3f87afbc96ee262014-05-01T00:00:00Zhttp://www.dovepress.com/enhanced-bioavailability-of-apigenin-via-preparation-of-a-carbon-nanop-a16805https://doaj.org/toc/1178-2013 Shu-min Ding,1–3 Zhen-hai Zhang,1,3 Jie Song,1,3 Xu-dong Cheng,1,3 Jun Jiang,1,3 Xiao-bin Jia1,31Affiliated Hospital on Integration of Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China; 2School of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou, People's Republic of China; 3Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing, People's Republic of ChinaAbstract: In this study, a novel carbon nanopowder (CNP) drug carrier was developed to improve the oral bioavailability of apigenin (AP). Solid dispersions (SDs) of AP with CNP were prepared, and their in vitro drug release and in vivo performance were evaluated. The physicochemical properties of the formulations were examined by differential scanning calorimetry, X-ray diffraction, and scanning electron microscopy. Drug release profiles showed that AP dissolution from the CNP-AP system (weight ratio, 6:1) after 60 minutes improved by 275% compared with that of pure AP. Moreover, the pharmacokinetic analysis of SD formulations in rats showed that the AP area under the curve0–t value was 1.83 times higher for the CNP-AP system than for pure AP, indicating that its bioavailability was significantly improved. In addition, compared with pure AP, SDs had a significantly higher peak and shorter time to peak. Preliminary intestinal toxicity tests indicated that there was no significant difference in the tissues of the rats treated with the CNP-AP system, rats treated with the CNP alone, and controls. In conclusion, CNP-based SDs could be used for enhancing the bioavailability of poorly water-soluble drugs while also improving drug safety.Keywords: apigenin, carbon nanopowder, solid dispersions, dissolution, oral bioavailabilityDing SMZhang ZHSong JCheng XDJiang JJia XBDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 2327-2333 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Ding SM Zhang ZH Song J Cheng XD Jiang J Jia XB Enhanced bioavailability of apigenin via preparation of a carbon nanopowder solid dispersion
description	Shu-min Ding,1–3 Zhen-hai Zhang,1,3 Jie Song,1,3 Xu-dong Cheng,1,3 Jun Jiang,1,3 Xiao-bin Jia1,31Affiliated Hospital on Integration of Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China; 2School of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou, People's Republic of China; 3Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing, People's Republic of ChinaAbstract: In this study, a novel carbon nanopowder (CNP) drug carrier was developed to improve the oral bioavailability of apigenin (AP). Solid dispersions (SDs) of AP with CNP were prepared, and their in vitro drug release and in vivo performance were evaluated. The physicochemical properties of the formulations were examined by differential scanning calorimetry, X-ray diffraction, and scanning electron microscopy. Drug release profiles showed that AP dissolution from the CNP-AP system (weight ratio, 6:1) after 60 minutes improved by 275% compared with that of pure AP. Moreover, the pharmacokinetic analysis of SD formulations in rats showed that the AP area under the curve0–t value was 1.83 times higher for the CNP-AP system than for pure AP, indicating that its bioavailability was significantly improved. In addition, compared with pure AP, SDs had a significantly higher peak and shorter time to peak. Preliminary intestinal toxicity tests indicated that there was no significant difference in the tissues of the rats treated with the CNP-AP system, rats treated with the CNP alone, and controls. In conclusion, CNP-based SDs could be used for enhancing the bioavailability of poorly water-soluble drugs while also improving drug safety.Keywords: apigenin, carbon nanopowder, solid dispersions, dissolution, oral bioavailability
format	article
author	Ding SM Zhang ZH Song J Cheng XD Jiang J Jia XB
author_facet	Ding SM Zhang ZH Song J Cheng XD Jiang J Jia XB
author_sort	Ding SM
title	Enhanced bioavailability of apigenin via preparation of a carbon nanopowder solid dispersion
title_short	Enhanced bioavailability of apigenin via preparation of a carbon nanopowder solid dispersion
title_full	Enhanced bioavailability of apigenin via preparation of a carbon nanopowder solid dispersion
title_fullStr	Enhanced bioavailability of apigenin via preparation of a carbon nanopowder solid dispersion
title_full_unstemmed	Enhanced bioavailability of apigenin via preparation of a carbon nanopowder solid dispersion
title_sort	enhanced bioavailability of apigenin via preparation of a carbon nanopowder solid dispersion
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/8d9eba1f51764d21af3f87afbc96ee26
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_version_	1718401200621092864

Enhanced bioavailability of apigenin via preparation of a carbon nanopowder solid dispersion

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