Intercalated disc protein Xinβ is required for Hippo-YAP signaling in the heart
Intercalated discs ensure mechanical and electrochemical coupling during contraction of the heart. Here, the authors show that loss of Xinβ results in cardiomyocyte proliferation defects and cardiomyopathy by influencing the Hippo-YAP signalling pathway, thus affecting cardiac development and functi...
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Nature Portfolio
2020
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oai:doaj.org-article:8da0d02d7d2444b1832b1613e9583e1a2021-12-02T18:02:16ZIntercalated disc protein Xinβ is required for Hippo-YAP signaling in the heart10.1038/s41467-020-18379-82041-1723https://doaj.org/article/8da0d02d7d2444b1832b1613e9583e1a2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18379-8https://doaj.org/toc/2041-1723Intercalated discs ensure mechanical and electrochemical coupling during contraction of the heart. Here, the authors show that loss of Xinβ results in cardiomyocyte proliferation defects and cardiomyopathy by influencing the Hippo-YAP signalling pathway, thus affecting cardiac development and function.Haipeng GuoYao Wei LuZhiqiang LinZhan-Peng HuangJianming LiuYi WangHee Young SeokXiaoyun HuQing MaKathryn LiJan KyselovicQingchuan WangJenny L.-C. LinJim J.-C. LinDouglas B. CowanFrancisco NayaYuguo ChenWilliam T. PuDa-Zhi WangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020) |
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DOAJ |
| collection |
DOAJ |
| language |
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| topic |
Science Q |
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Science Q Haipeng Guo Yao Wei Lu Zhiqiang Lin Zhan-Peng Huang Jianming Liu Yi Wang Hee Young Seok Xiaoyun Hu Qing Ma Kathryn Li Jan Kyselovic Qingchuan Wang Jenny L.-C. Lin Jim J.-C. Lin Douglas B. Cowan Francisco Naya Yuguo Chen William T. Pu Da-Zhi Wang Intercalated disc protein Xinβ is required for Hippo-YAP signaling in the heart |
| description |
Intercalated discs ensure mechanical and electrochemical coupling during contraction of the heart. Here, the authors show that loss of Xinβ results in cardiomyocyte proliferation defects and cardiomyopathy by influencing the Hippo-YAP signalling pathway, thus affecting cardiac development and function. |
| format |
article |
| author |
Haipeng Guo Yao Wei Lu Zhiqiang Lin Zhan-Peng Huang Jianming Liu Yi Wang Hee Young Seok Xiaoyun Hu Qing Ma Kathryn Li Jan Kyselovic Qingchuan Wang Jenny L.-C. Lin Jim J.-C. Lin Douglas B. Cowan Francisco Naya Yuguo Chen William T. Pu Da-Zhi Wang |
| author_facet |
Haipeng Guo Yao Wei Lu Zhiqiang Lin Zhan-Peng Huang Jianming Liu Yi Wang Hee Young Seok Xiaoyun Hu Qing Ma Kathryn Li Jan Kyselovic Qingchuan Wang Jenny L.-C. Lin Jim J.-C. Lin Douglas B. Cowan Francisco Naya Yuguo Chen William T. Pu Da-Zhi Wang |
| author_sort |
Haipeng Guo |
| title |
Intercalated disc protein Xinβ is required for Hippo-YAP signaling in the heart |
| title_short |
Intercalated disc protein Xinβ is required for Hippo-YAP signaling in the heart |
| title_full |
Intercalated disc protein Xinβ is required for Hippo-YAP signaling in the heart |
| title_fullStr |
Intercalated disc protein Xinβ is required for Hippo-YAP signaling in the heart |
| title_full_unstemmed |
Intercalated disc protein Xinβ is required for Hippo-YAP signaling in the heart |
| title_sort |
intercalated disc protein xinβ is required for hippo-yap signaling in the heart |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/8da0d02d7d2444b1832b1613e9583e1a |
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