Corneal endothelium and central corneal thickness changes in type 2 diabetes mellitus

Amira El-Agamy,1,2,* Shams Alsubaie3,* 1Department of Optometry and Vision Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia; 2Mansoura Ophthalmic Center, Faculty of Medicine, Mansoura University, Mansoura, Egypt; 3Department of Optometry and Vision Sciences,...

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Autores principales:	El-Agamy A, Alsubaie S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Endothelial cell density Central corneal thickness and Diabetes Mellitus Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/8da8a18f74cb4993b03853b4a6bf196f
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spelling	oai:doaj.org-article:8da8a18f74cb4993b03853b4a6bf196f2021-12-02T04:43:09ZCorneal endothelium and central corneal thickness changes in type 2 diabetes mellitus1177-5483https://doaj.org/article/8da8a18f74cb4993b03853b4a6bf196f2017-03-01T00:00:00Zhttps://www.dovepress.com/corneal-endothelium-and-central-corneal-thickness-changes-in-type-2-di-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Amira El-Agamy,1,2,* Shams Alsubaie3,* 1Department of Optometry and Vision Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia; 2Mansoura Ophthalmic Center, Faculty of Medicine, Mansoura University, Mansoura, Egypt; 3Department of Optometry and Vision Sciences, Sulaiman Al Habib Hospital, Riyadh, Saudi Arabia *These authors contributed equally to this work Purpose: This study was conducted to compare the corneal endothelial cell density (ECD), morphological features, and central corneal thickness (CCT) in type 2 diabetes mellitus (DM) with age-matched, nondiabetic control subjects using EM-3000 Specular Microscope. Study design: This was a prospective, hospital-based, nonrandomized, case–control, observational, and quantitative study. Subjects and methods: The study included 57 patients (57 eyes) with type 2 DM and 45 control (nondiabetic) subjects (45 eyes). The corneal endothelial structure and CCT were examined in all eyes by noncontact specular microscopy using EM-3000 Specular Microscope. The endothelial structure was studied for ECD, coefficient of variation of cell area (CV), and percentage of hexagonal cells. Results: The study included 36 eyes without diabetic retinopathy (DR), 14 eyes with nonproliferative DR, and 7 eyes with proliferative DR. There were 26 eyes with a duration of ≤10 years and 31 eyes with a duration of >10 years. Also, there were 24 eyes with HbA1c ≤7.5% and 33 eyes with HbA1c >7.5%. ECD was significantly lower in the diabetic cornea than in control group (P=0.014). CV was higher in diabetic cornea (P=0.008). The diabetic cornea group had lower percentage of hexagonal cells than the control group, but the difference was not statistically significant (P=0.603). Also, diabetic cornea was thicker than control group, but not statistically significant (P=0.301). Conclusion: This study documented that type 2 DM causes a significant reduction of ECD and increased CV (polymegathism). Also, diabetic cornea has increased CCT and lower percentage of hexagonal cells than normal subjects, but without statistical significance. Keywords: endothelial cell density, central corneal thickness, diabetes mellitus, diabetic retinopathy, noncontact specular microscopyEl-Agamy AAlsubaie SDove Medical PressarticleEndothelial cell densityCentral corneal thickness and Diabetes MellitusOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 11, Pp 481-486 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Endothelial cell density Central corneal thickness and Diabetes Mellitus Ophthalmology RE1-994
spellingShingle	Endothelial cell density Central corneal thickness and Diabetes Mellitus Ophthalmology RE1-994 El-Agamy A Alsubaie S Corneal endothelium and central corneal thickness changes in type 2 diabetes mellitus
description	Amira El-Agamy,1,2,* Shams Alsubaie3,* 1Department of Optometry and Vision Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia; 2Mansoura Ophthalmic Center, Faculty of Medicine, Mansoura University, Mansoura, Egypt; 3Department of Optometry and Vision Sciences, Sulaiman Al Habib Hospital, Riyadh, Saudi Arabia *These authors contributed equally to this work Purpose: This study was conducted to compare the corneal endothelial cell density (ECD), morphological features, and central corneal thickness (CCT) in type 2 diabetes mellitus (DM) with age-matched, nondiabetic control subjects using EM-3000 Specular Microscope. Study design: This was a prospective, hospital-based, nonrandomized, case–control, observational, and quantitative study. Subjects and methods: The study included 57 patients (57 eyes) with type 2 DM and 45 control (nondiabetic) subjects (45 eyes). The corneal endothelial structure and CCT were examined in all eyes by noncontact specular microscopy using EM-3000 Specular Microscope. The endothelial structure was studied for ECD, coefficient of variation of cell area (CV), and percentage of hexagonal cells. Results: The study included 36 eyes without diabetic retinopathy (DR), 14 eyes with nonproliferative DR, and 7 eyes with proliferative DR. There were 26 eyes with a duration of ≤10 years and 31 eyes with a duration of >10 years. Also, there were 24 eyes with HbA1c ≤7.5% and 33 eyes with HbA1c >7.5%. ECD was significantly lower in the diabetic cornea than in control group (P=0.014). CV was higher in diabetic cornea (P=0.008). The diabetic cornea group had lower percentage of hexagonal cells than the control group, but the difference was not statistically significant (P=0.603). Also, diabetic cornea was thicker than control group, but not statistically significant (P=0.301). Conclusion: This study documented that type 2 DM causes a significant reduction of ECD and increased CV (polymegathism). Also, diabetic cornea has increased CCT and lower percentage of hexagonal cells than normal subjects, but without statistical significance. Keywords: endothelial cell density, central corneal thickness, diabetes mellitus, diabetic retinopathy, noncontact specular microscopy
format	article
author	El-Agamy A Alsubaie S
author_facet	El-Agamy A Alsubaie S
author_sort	El-Agamy A
title	Corneal endothelium and central corneal thickness changes in type 2 diabetes mellitus
title_short	Corneal endothelium and central corneal thickness changes in type 2 diabetes mellitus
title_full	Corneal endothelium and central corneal thickness changes in type 2 diabetes mellitus
title_fullStr	Corneal endothelium and central corneal thickness changes in type 2 diabetes mellitus
title_full_unstemmed	Corneal endothelium and central corneal thickness changes in type 2 diabetes mellitus
title_sort	corneal endothelium and central corneal thickness changes in type 2 diabetes mellitus
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/8da8a18f74cb4993b03853b4a6bf196f
work_keys_str_mv	AT elagamya cornealendotheliumandcentralcornealthicknesschangesintype2diabetesmellitus AT alsubaies cornealendotheliumandcentralcornealthicknesschangesintype2diabetesmellitus
_version_	1718401092282220544

Corneal endothelium and central corneal thickness changes in type 2 diabetes mellitus

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