Spatial regulation by multiple Gremlin1 enhancers provides digit development with cis-regulatory robustness and evolutionary plasticity

The BMP antagonist Gremlin1 balances BMP and SHH signalling, endowing limb bud development with robustness. Here, the authors identify enhancers controlling Grem1 levels in an additive, and spatial regulation in a synergistic manner, providing digit patterning with cis-regulatory robustness and evol...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jonas Malkmus, Laurène Ramos Martins, Shalu Jhanwar, Bonnie Kircher, Victorio Palacio, Rushikesh Sheth, Francisca Leal, Amandine Duchesne, Javier Lopez-Rios, Kevin A. Peterson, Robert Reinhardt, Koh Onimaru, Martin J. Cohn, Aimée Zuniga, Rolf Zeller
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8daa3afd4ca340eaad289f8348f3805b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8daa3afd4ca340eaad289f8348f3805b
record_format	dspace
spelling	oai:doaj.org-article:8daa3afd4ca340eaad289f8348f3805b2021-12-02T18:14:23ZSpatial regulation by multiple Gremlin1 enhancers provides digit development with cis-regulatory robustness and evolutionary plasticity10.1038/s41467-021-25810-12041-1723https://doaj.org/article/8daa3afd4ca340eaad289f8348f3805b2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25810-1https://doaj.org/toc/2041-1723The BMP antagonist Gremlin1 balances BMP and SHH signalling, endowing limb bud development with robustness. Here, the authors identify enhancers controlling Grem1 levels in an additive, and spatial regulation in a synergistic manner, providing digit patterning with cis-regulatory robustness and evolutionary plasticity.Jonas MalkmusLaurène Ramos MartinsShalu JhanwarBonnie KircherVictorio PalacioRushikesh ShethFrancisca LealAmandine DuchesneJavier Lopez-RiosKevin A. PetersonRobert ReinhardtKoh OnimaruMartin J. CohnAimée ZunigaRolf ZellerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jonas Malkmus Laurène Ramos Martins Shalu Jhanwar Bonnie Kircher Victorio Palacio Rushikesh Sheth Francisca Leal Amandine Duchesne Javier Lopez-Rios Kevin A. Peterson Robert Reinhardt Koh Onimaru Martin J. Cohn Aimée Zuniga Rolf Zeller Spatial regulation by multiple Gremlin1 enhancers provides digit development with cis-regulatory robustness and evolutionary plasticity
description	The BMP antagonist Gremlin1 balances BMP and SHH signalling, endowing limb bud development with robustness. Here, the authors identify enhancers controlling Grem1 levels in an additive, and spatial regulation in a synergistic manner, providing digit patterning with cis-regulatory robustness and evolutionary plasticity.
format	article
author	Jonas Malkmus Laurène Ramos Martins Shalu Jhanwar Bonnie Kircher Victorio Palacio Rushikesh Sheth Francisca Leal Amandine Duchesne Javier Lopez-Rios Kevin A. Peterson Robert Reinhardt Koh Onimaru Martin J. Cohn Aimée Zuniga Rolf Zeller
author_facet	Jonas Malkmus Laurène Ramos Martins Shalu Jhanwar Bonnie Kircher Victorio Palacio Rushikesh Sheth Francisca Leal Amandine Duchesne Javier Lopez-Rios Kevin A. Peterson Robert Reinhardt Koh Onimaru Martin J. Cohn Aimée Zuniga Rolf Zeller
author_sort	Jonas Malkmus
title	Spatial regulation by multiple Gremlin1 enhancers provides digit development with cis-regulatory robustness and evolutionary plasticity
title_short	Spatial regulation by multiple Gremlin1 enhancers provides digit development with cis-regulatory robustness and evolutionary plasticity
title_full	Spatial regulation by multiple Gremlin1 enhancers provides digit development with cis-regulatory robustness and evolutionary plasticity
title_fullStr	Spatial regulation by multiple Gremlin1 enhancers provides digit development with cis-regulatory robustness and evolutionary plasticity
title_full_unstemmed	Spatial regulation by multiple Gremlin1 enhancers provides digit development with cis-regulatory robustness and evolutionary plasticity
title_sort	spatial regulation by multiple gremlin1 enhancers provides digit development with cis-regulatory robustness and evolutionary plasticity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8daa3afd4ca340eaad289f8348f3805b
work_keys_str_mv	AT jonasmalkmus spatialregulationbymultiplegremlin1enhancersprovidesdigitdevelopmentwithcisregulatoryrobustnessandevolutionaryplasticity AT laureneramosmartins spatialregulationbymultiplegremlin1enhancersprovidesdigitdevelopmentwithcisregulatoryrobustnessandevolutionaryplasticity AT shalujhanwar spatialregulationbymultiplegremlin1enhancersprovidesdigitdevelopmentwithcisregulatoryrobustnessandevolutionaryplasticity AT bonniekircher spatialregulationbymultiplegremlin1enhancersprovidesdigitdevelopmentwithcisregulatoryrobustnessandevolutionaryplasticity AT victoriopalacio spatialregulationbymultiplegremlin1enhancersprovidesdigitdevelopmentwithcisregulatoryrobustnessandevolutionaryplasticity AT rushikeshsheth spatialregulationbymultiplegremlin1enhancersprovidesdigitdevelopmentwithcisregulatoryrobustnessandevolutionaryplasticity AT franciscaleal spatialregulationbymultiplegremlin1enhancersprovidesdigitdevelopmentwithcisregulatoryrobustnessandevolutionaryplasticity AT amandineduchesne spatialregulationbymultiplegremlin1enhancersprovidesdigitdevelopmentwithcisregulatoryrobustnessandevolutionaryplasticity AT javierlopezrios spatialregulationbymultiplegremlin1enhancersprovidesdigitdevelopmentwithcisregulatoryrobustnessandevolutionaryplasticity AT kevinapeterson spatialregulationbymultiplegremlin1enhancersprovidesdigitdevelopmentwithcisregulatoryrobustnessandevolutionaryplasticity AT robertreinhardt spatialregulationbymultiplegremlin1enhancersprovidesdigitdevelopmentwithcisregulatoryrobustnessandevolutionaryplasticity AT kohonimaru spatialregulationbymultiplegremlin1enhancersprovidesdigitdevelopmentwithcisregulatoryrobustnessandevolutionaryplasticity AT martinjcohn spatialregulationbymultiplegremlin1enhancersprovidesdigitdevelopmentwithcisregulatoryrobustnessandevolutionaryplasticity AT aimeezuniga spatialregulationbymultiplegremlin1enhancersprovidesdigitdevelopmentwithcisregulatoryrobustnessandevolutionaryplasticity AT rolfzeller spatialregulationbymultiplegremlin1enhancersprovidesdigitdevelopmentwithcisregulatoryrobustnessandevolutionaryplasticity
_version_	1718378406580584448

Spatial regulation by multiple Gremlin1 enhancers provides digit development with cis-regulatory robustness and evolutionary plasticity

Ejemplares similares