E. coli Nissle 1917 modulates host glucose metabolism without directly acting on glucose

Abstract Managing postprandial glycemic response, or the increase in blood sugar following a meal, is a crucial component to maintaining healthy blood sugar in patients with diabetes. To test whether oral probiotics can impact postprandial glycemic response, E. coli Nissle 1917 (EcN) was evaluated i...

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Autores principales:	Theodore A. Chavkin, Loc-Duyen Pham, Aleksandar Kostic
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8dacacaffa964e7084de81e4789ff5a4
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spelling	oai:doaj.org-article:8dacacaffa964e7084de81e4789ff5a42021-12-05T12:15:12ZE. coli Nissle 1917 modulates host glucose metabolism without directly acting on glucose10.1038/s41598-021-02431-82045-2322https://doaj.org/article/8dacacaffa964e7084de81e4789ff5a42021-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02431-8https://doaj.org/toc/2045-2322Abstract Managing postprandial glycemic response, or the increase in blood sugar following a meal, is a crucial component to maintaining healthy blood sugar in patients with diabetes. To test whether oral probiotics can impact postprandial glycemic response, E. coli Nissle 1917 (EcN) was evaluated in an oral glucose tolerance test. Oral gavage of EcN concurrent with a glucose bolus reduced the post-gavage glycemic response in mice. However, there was no difference in glycemic response when comparing EcN to a mutant deficient in glucose metabolism. This suggests that while EcN can alter glycemic response to a glucose bolus, this effect is not mediated by direct uptake of glucose. Of the possible indirect effects EcN could have, gastric emptying rate was highlighted as a likely cause, but EcN had no effect on gastric emptying rate in mice. This leaves many more possible indirect explanations for the interaction between EcN and host glucose metabolism to be explored in future work.Theodore A. ChavkinLoc-Duyen PhamAleksandar KosticNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Theodore A. Chavkin Loc-Duyen Pham Aleksandar Kostic E. coli Nissle 1917 modulates host glucose metabolism without directly acting on glucose
description	Abstract Managing postprandial glycemic response, or the increase in blood sugar following a meal, is a crucial component to maintaining healthy blood sugar in patients with diabetes. To test whether oral probiotics can impact postprandial glycemic response, E. coli Nissle 1917 (EcN) was evaluated in an oral glucose tolerance test. Oral gavage of EcN concurrent with a glucose bolus reduced the post-gavage glycemic response in mice. However, there was no difference in glycemic response when comparing EcN to a mutant deficient in glucose metabolism. This suggests that while EcN can alter glycemic response to a glucose bolus, this effect is not mediated by direct uptake of glucose. Of the possible indirect effects EcN could have, gastric emptying rate was highlighted as a likely cause, but EcN had no effect on gastric emptying rate in mice. This leaves many more possible indirect explanations for the interaction between EcN and host glucose metabolism to be explored in future work.
format	article
author	Theodore A. Chavkin Loc-Duyen Pham Aleksandar Kostic
author_facet	Theodore A. Chavkin Loc-Duyen Pham Aleksandar Kostic
author_sort	Theodore A. Chavkin
title	E. coli Nissle 1917 modulates host glucose metabolism without directly acting on glucose
title_short	E. coli Nissle 1917 modulates host glucose metabolism without directly acting on glucose
title_full	E. coli Nissle 1917 modulates host glucose metabolism without directly acting on glucose
title_fullStr	E. coli Nissle 1917 modulates host glucose metabolism without directly acting on glucose
title_full_unstemmed	E. coli Nissle 1917 modulates host glucose metabolism without directly acting on glucose
title_sort	e. coli nissle 1917 modulates host glucose metabolism without directly acting on glucose
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8dacacaffa964e7084de81e4789ff5a4
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E. coli Nissle 1917 modulates host glucose metabolism without directly acting on glucose

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