Accurate and scalable variant calling from single cell DNA sequencing data with ProSolo

Obtaining accurate variant calls from multiple displacement amplified single cell DNA sequencing data needs dedicated models that account for amplification bias and copy errors. Here, the authors describe ProSolo, a model for calling single nucleotide variants with control over the false discovery r...

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Autores principales: David Lähnemann, Johannes Köster, Ute Fischer, Arndt Borkhardt, Alice C. McHardy, Alexander Schönhuth
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/8db091b26b934b4bafe06184a93555fe
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Sumario:Obtaining accurate variant calls from multiple displacement amplified single cell DNA sequencing data needs dedicated models that account for amplification bias and copy errors. Here, the authors describe ProSolo, a model for calling single nucleotide variants with control over the false discovery rate.