Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats

Withdrawal from alcohol activates neurons in the central amygdala (CeA) and increases craving for alcohol. The authors show that these neurons predominantly express CRF and project to the BNST. Inactivation of this pathway reduces the dependence-related escalation of alcohol drinking.

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Autores principales:	Giordano de Guglielmo, Marsida Kallupi, Matthew B. Pomrenze, Elena Crawford, Sierra Simpson, Paul Schweitzer, George F. Koob, Robert O. Messing, Olivier George
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8db57a0776314be7af8485f7e6d97794
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spelling	oai:doaj.org-article:8db57a0776314be7af8485f7e6d977942021-12-02T14:38:43ZInactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats10.1038/s41467-019-09183-02041-1723https://doaj.org/article/8db57a0776314be7af8485f7e6d977942019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09183-0https://doaj.org/toc/2041-1723Withdrawal from alcohol activates neurons in the central amygdala (CeA) and increases craving for alcohol. The authors show that these neurons predominantly express CRF and project to the BNST. Inactivation of this pathway reduces the dependence-related escalation of alcohol drinking.Giordano de GuglielmoMarsida KallupiMatthew B. PomrenzeElena CrawfordSierra SimpsonPaul SchweitzerGeorge F. KoobRobert O. MessingOlivier GeorgeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Giordano de Guglielmo Marsida Kallupi Matthew B. Pomrenze Elena Crawford Sierra Simpson Paul Schweitzer George F. Koob Robert O. Messing Olivier George Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats
description	Withdrawal from alcohol activates neurons in the central amygdala (CeA) and increases craving for alcohol. The authors show that these neurons predominantly express CRF and project to the BNST. Inactivation of this pathway reduces the dependence-related escalation of alcohol drinking.
format	article
author	Giordano de Guglielmo Marsida Kallupi Matthew B. Pomrenze Elena Crawford Sierra Simpson Paul Schweitzer George F. Koob Robert O. Messing Olivier George
author_facet	Giordano de Guglielmo Marsida Kallupi Matthew B. Pomrenze Elena Crawford Sierra Simpson Paul Schweitzer George F. Koob Robert O. Messing Olivier George
author_sort	Giordano de Guglielmo
title	Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats
title_short	Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats
title_full	Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats
title_fullStr	Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats
title_full_unstemmed	Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats
title_sort	inactivation of a crf-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/8db57a0776314be7af8485f7e6d97794
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Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats

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