Constructing chiral bicyclo[3.2.1]octanes via palladium-catalyzed asymmetric tandem Heck/carbonylation desymmetrization of cyclopentenes

Tandem Heck/carbonylation reaction gives access to ubiquitous carbonyl molecules, however the asymmetric version is rarely studied. Here, the authors synthesize chiral bicyclo[3.2.1]octanes with a palladium-catalyzed asymmetric tandem Heck/carbonylation desymmetrization of cyclopentenes with alcohol...

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Autores principales:	Zhenbo Yuan, Yuye Zeng, Ziwen Feng, Zhe Guan, Aijun Lin, Hequan Yao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8db740ae56e844d88c1f4318a0aea403
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spelling	oai:doaj.org-article:8db740ae56e844d88c1f4318a0aea4032021-12-02T16:49:45ZConstructing chiral bicyclo[3.2.1]octanes via palladium-catalyzed asymmetric tandem Heck/carbonylation desymmetrization of cyclopentenes10.1038/s41467-020-16221-92041-1723https://doaj.org/article/8db740ae56e844d88c1f4318a0aea4032020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16221-9https://doaj.org/toc/2041-1723Tandem Heck/carbonylation reaction gives access to ubiquitous carbonyl molecules, however the asymmetric version is rarely studied. Here, the authors synthesize chiral bicyclo[3.2.1]octanes with a palladium-catalyzed asymmetric tandem Heck/carbonylation desymmetrization of cyclopentenes with alcohols, phenols and amines.Zhenbo YuanYuye ZengZiwen FengZhe GuanAijun LinHequan YaoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhenbo Yuan Yuye Zeng Ziwen Feng Zhe Guan Aijun Lin Hequan Yao Constructing chiral bicyclo[3.2.1]octanes via palladium-catalyzed asymmetric tandem Heck/carbonylation desymmetrization of cyclopentenes
description	Tandem Heck/carbonylation reaction gives access to ubiquitous carbonyl molecules, however the asymmetric version is rarely studied. Here, the authors synthesize chiral bicyclo[3.2.1]octanes with a palladium-catalyzed asymmetric tandem Heck/carbonylation desymmetrization of cyclopentenes with alcohols, phenols and amines.
format	article
author	Zhenbo Yuan Yuye Zeng Ziwen Feng Zhe Guan Aijun Lin Hequan Yao
author_facet	Zhenbo Yuan Yuye Zeng Ziwen Feng Zhe Guan Aijun Lin Hequan Yao
author_sort	Zhenbo Yuan
title	Constructing chiral bicyclo[3.2.1]octanes via palladium-catalyzed asymmetric tandem Heck/carbonylation desymmetrization of cyclopentenes
title_short	Constructing chiral bicyclo[3.2.1]octanes via palladium-catalyzed asymmetric tandem Heck/carbonylation desymmetrization of cyclopentenes
title_full	Constructing chiral bicyclo[3.2.1]octanes via palladium-catalyzed asymmetric tandem Heck/carbonylation desymmetrization of cyclopentenes
title_fullStr	Constructing chiral bicyclo[3.2.1]octanes via palladium-catalyzed asymmetric tandem Heck/carbonylation desymmetrization of cyclopentenes
title_full_unstemmed	Constructing chiral bicyclo[3.2.1]octanes via palladium-catalyzed asymmetric tandem Heck/carbonylation desymmetrization of cyclopentenes
title_sort	constructing chiral bicyclo[3.2.1]octanes via palladium-catalyzed asymmetric tandem heck/carbonylation desymmetrization of cyclopentenes
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8db740ae56e844d88c1f4318a0aea403
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Constructing chiral bicyclo[3.2.1]octanes via palladium-catalyzed asymmetric tandem Heck/carbonylation desymmetrization of cyclopentenes

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