Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study
APOE is the major genetic risk factor for Alzheimer’s disease. In a large number of neuropathologically confirmed cases and controls, the impact of different APOE genotypes on Alzheimer’s dementia risk was greater than previously thought and APOE2 homozygotes had an exceptionally low risk.
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Nature Portfolio
2020
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oai:doaj.org-article:8db8cb1befa541b785dc4ef2890379012021-12-02T16:49:45ZExceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study10.1038/s41467-019-14279-82041-1723https://doaj.org/article/8db8cb1befa541b785dc4ef2890379012020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14279-8https://doaj.org/toc/2041-1723APOE is the major genetic risk factor for Alzheimer’s disease. In a large number of neuropathologically confirmed cases and controls, the impact of different APOE genotypes on Alzheimer’s dementia risk was greater than previously thought and APOE2 homozygotes had an exceptionally low risk.Eric M. ReimanJoseph F. Arboleda-VelasquezYakeel T. QuirozMatthew J. HuentelmanThomas G. BeachRichard J. CaselliYinghua ChenYi SuAmanda J. MyersJohn HardyJean Paul VonsattelSteven G. YounkinDavid A. BennettPhilip L. De JagerEric B. LarsonPaul K. CraneC. Dirk KeeneM. Ilyas KambohJulia K. KoflerLinda DuqueJohn R. GilbertHarry E. GwirtsmanJoseph D. BuxbaumDennis W. DicksonMatthew P. FroschBernardino F. GhettiKathryn L. LunettaLi-San WangBradley T. HymanWalter A. KukullTatiana ForoudJonathan L. HainesRichard P. MayeuxMargaret A. Pericak-VanceJulie A. SchneiderJohn Q. TrojanowskiLindsay A. FarrerGerard D. SchellenbergGary W. BeechamThomas J. MontineGyungah R. JunThe Alzheimer’s Disease Genetics ConsortiumNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020) |
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DOAJ |
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EN |
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Science Q |
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Science Q Eric M. Reiman Joseph F. Arboleda-Velasquez Yakeel T. Quiroz Matthew J. Huentelman Thomas G. Beach Richard J. Caselli Yinghua Chen Yi Su Amanda J. Myers John Hardy Jean Paul Vonsattel Steven G. Younkin David A. Bennett Philip L. De Jager Eric B. Larson Paul K. Crane C. Dirk Keene M. Ilyas Kamboh Julia K. Kofler Linda Duque John R. Gilbert Harry E. Gwirtsman Joseph D. Buxbaum Dennis W. Dickson Matthew P. Frosch Bernardino F. Ghetti Kathryn L. Lunetta Li-San Wang Bradley T. Hyman Walter A. Kukull Tatiana Foroud Jonathan L. Haines Richard P. Mayeux Margaret A. Pericak-Vance Julie A. Schneider John Q. Trojanowski Lindsay A. Farrer Gerard D. Schellenberg Gary W. Beecham Thomas J. Montine Gyungah R. Jun The Alzheimer’s Disease Genetics Consortium Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study |
| description |
APOE is the major genetic risk factor for Alzheimer’s disease. In a large number of neuropathologically confirmed cases and controls, the impact of different APOE genotypes on Alzheimer’s dementia risk was greater than previously thought and APOE2 homozygotes had an exceptionally low risk. |
| format |
article |
| author |
Eric M. Reiman Joseph F. Arboleda-Velasquez Yakeel T. Quiroz Matthew J. Huentelman Thomas G. Beach Richard J. Caselli Yinghua Chen Yi Su Amanda J. Myers John Hardy Jean Paul Vonsattel Steven G. Younkin David A. Bennett Philip L. De Jager Eric B. Larson Paul K. Crane C. Dirk Keene M. Ilyas Kamboh Julia K. Kofler Linda Duque John R. Gilbert Harry E. Gwirtsman Joseph D. Buxbaum Dennis W. Dickson Matthew P. Frosch Bernardino F. Ghetti Kathryn L. Lunetta Li-San Wang Bradley T. Hyman Walter A. Kukull Tatiana Foroud Jonathan L. Haines Richard P. Mayeux Margaret A. Pericak-Vance Julie A. Schneider John Q. Trojanowski Lindsay A. Farrer Gerard D. Schellenberg Gary W. Beecham Thomas J. Montine Gyungah R. Jun The Alzheimer’s Disease Genetics Consortium |
| author_facet |
Eric M. Reiman Joseph F. Arboleda-Velasquez Yakeel T. Quiroz Matthew J. Huentelman Thomas G. Beach Richard J. Caselli Yinghua Chen Yi Su Amanda J. Myers John Hardy Jean Paul Vonsattel Steven G. Younkin David A. Bennett Philip L. De Jager Eric B. Larson Paul K. Crane C. Dirk Keene M. Ilyas Kamboh Julia K. Kofler Linda Duque John R. Gilbert Harry E. Gwirtsman Joseph D. Buxbaum Dennis W. Dickson Matthew P. Frosch Bernardino F. Ghetti Kathryn L. Lunetta Li-San Wang Bradley T. Hyman Walter A. Kukull Tatiana Foroud Jonathan L. Haines Richard P. Mayeux Margaret A. Pericak-Vance Julie A. Schneider John Q. Trojanowski Lindsay A. Farrer Gerard D. Schellenberg Gary W. Beecham Thomas J. Montine Gyungah R. Jun The Alzheimer’s Disease Genetics Consortium |
| author_sort |
Eric M. Reiman |
| title |
Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study |
| title_short |
Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study |
| title_full |
Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study |
| title_fullStr |
Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study |
| title_full_unstemmed |
Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study |
| title_sort |
exceptionally low likelihood of alzheimer’s dementia in apoe2 homozygotes from a 5,000-person neuropathological study |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/8db8cb1befa541b785dc4ef289037901 |
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