Bromocriptine approved as the first medication to target dopamine activity to improve glycemic control in patients with type 2 diabetes

Michael A Via1, Himani Chandra2, Takako Araki1, Matthew V Potenza3, Maria Skamagas41Division of Endocrinology and Metabolism, Albert Einstein College of Medicine, Beth Israel Medical Center, New York, NY, USA; 2Division of Endocrinology, Diabetes and Bone Disease, Mount Sinai School of Medicine, Jam...

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Autores principales:	Michael A Via, Himani Chandra, Takako Araki, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/8db9092bc7954a75aa607adcf098547f
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spelling	oai:doaj.org-article:8db9092bc7954a75aa607adcf098547f2021-12-02T04:55:17ZBromocriptine approved as the first medication to target dopamine activity to improve glycemic control in patients with type 2 diabetes1178-7007https://doaj.org/article/8db9092bc7954a75aa607adcf098547f2010-03-01T00:00:00Zhttp://www.dovepress.com/bromocriptine-approved-as-the-first-medication-to-target-dopamine-acti-a4134https://doaj.org/toc/1178-7007Michael A Via1, Himani Chandra2, Takako Araki1, Matthew V Potenza3, Maria Skamagas41Division of Endocrinology and Metabolism, Albert Einstein College of Medicine, Beth Israel Medical Center, New York, NY, USA; 2Division of Endocrinology, Diabetes and Bone Disease, Mount Sinai School of Medicine, James J Peters VA Medical Center, New York, NY, USA; 3Diabetes and Endocrinology, West Nyack, New York, NY, USA; 4Division of Endocrinology, Diabetes and Bone Disease, Mount Sinai School of Medicine, New York, NY, USAAbstract: Type 2 diabetes mellitus (T2DM) continues to rise in prevalence in the United States and worldwide. Despite advances in medical treatments for T2DM, many patients remain uncontrolled. By targeting centrally mediated pathways of glucose metabolism, bromocriptine represents a novel therapeutic option in T2DM. Several small clinical trials demonstrate improvements in insulin resistance and glycemic control. After the submission of data from four recent, large clinical trials, the US Food and Drug Administration has approved the use of bromocriptine in T2DM. We review the available data from these four trials and other published studies. Bromocriptine is a promising therapy for diabetes patients and demonstrates modest improvements in glycemic control.Keywords: bromocriptine, dopamine agonists, diabetes, glycemic control Michael A ViaHimani ChandraTakako Arakiet alDove Medical PressarticleSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2010, Iss default, Pp 43-48 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Specialties of internal medicine RC581-951
spellingShingle	Specialties of internal medicine RC581-951 Michael A Via Himani Chandra Takako Araki et al Bromocriptine approved as the first medication to target dopamine activity to improve glycemic control in patients with type 2 diabetes
description	Michael A Via1, Himani Chandra2, Takako Araki1, Matthew V Potenza3, Maria Skamagas41Division of Endocrinology and Metabolism, Albert Einstein College of Medicine, Beth Israel Medical Center, New York, NY, USA; 2Division of Endocrinology, Diabetes and Bone Disease, Mount Sinai School of Medicine, James J Peters VA Medical Center, New York, NY, USA; 3Diabetes and Endocrinology, West Nyack, New York, NY, USA; 4Division of Endocrinology, Diabetes and Bone Disease, Mount Sinai School of Medicine, New York, NY, USAAbstract: Type 2 diabetes mellitus (T2DM) continues to rise in prevalence in the United States and worldwide. Despite advances in medical treatments for T2DM, many patients remain uncontrolled. By targeting centrally mediated pathways of glucose metabolism, bromocriptine represents a novel therapeutic option in T2DM. Several small clinical trials demonstrate improvements in insulin resistance and glycemic control. After the submission of data from four recent, large clinical trials, the US Food and Drug Administration has approved the use of bromocriptine in T2DM. We review the available data from these four trials and other published studies. Bromocriptine is a promising therapy for diabetes patients and demonstrates modest improvements in glycemic control.Keywords: bromocriptine, dopamine agonists, diabetes, glycemic control
format	article
author	Michael A Via Himani Chandra Takako Araki et al
author_facet	Michael A Via Himani Chandra Takako Araki et al
author_sort	Michael A Via
title	Bromocriptine approved as the first medication to target dopamine activity to improve glycemic control in patients with type 2 diabetes
title_short	Bromocriptine approved as the first medication to target dopamine activity to improve glycemic control in patients with type 2 diabetes
title_full	Bromocriptine approved as the first medication to target dopamine activity to improve glycemic control in patients with type 2 diabetes
title_fullStr	Bromocriptine approved as the first medication to target dopamine activity to improve glycemic control in patients with type 2 diabetes
title_full_unstemmed	Bromocriptine approved as the first medication to target dopamine activity to improve glycemic control in patients with type 2 diabetes
title_sort	bromocriptine approved as the first medication to target dopamine activity to improve glycemic control in patients with type 2 diabetes
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/8db9092bc7954a75aa607adcf098547f
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Bromocriptine approved as the first medication to target dopamine activity to improve glycemic control in patients with type 2 diabetes

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