Incidence of hepatitis C infection among prisoners by routine laboratory values during a 20-year period.

<h4>Background</h4>To estimate the incidence of Hepatitis C virus (HCV) and the predictive factors through repeated routine laboratory analyses.<h4>Methods</h4>An observational cohort study was carried out in Quatre Camins Prison, Barcelona. The study included subjects with a...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Andrés Marco, Carlos Gallego, Joan A Caylà
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8dbaa3cfdd8042adabdfff8c27e68b95
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8dbaa3cfdd8042adabdfff8c27e68b95
record_format	dspace
spelling	oai:doaj.org-article:8dbaa3cfdd8042adabdfff8c27e68b952021-11-18T08:30:14ZIncidence of hepatitis C infection among prisoners by routine laboratory values during a 20-year period.1932-620310.1371/journal.pone.0090560https://doaj.org/article/8dbaa3cfdd8042adabdfff8c27e68b952014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24587394/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>To estimate the incidence of Hepatitis C virus (HCV) and the predictive factors through repeated routine laboratory analyses.<h4>Methods</h4>An observational cohort study was carried out in Quatre Camins Prison, Barcelona. The study included subjects with an initial negative HCV result and routine laboratory analyses containing HCV serology from 1992 to 2011. The incidence of infection was calculated for the study population and for sub-groups by 100 person-years of follow-up (100 py). The predictive factors were determined through Kaplan-Meier curves and a Cox regression. Hazard ratios (HR) and 95% confidence intervals (CI) were calculated.<h4>Results</h4>A total of 2,377 prisoners were included with a median follow-up time of 1,540.9 days per patient. Among the total population, 117 HCV seroconversions were detected (incidence of 1.17/100 py). The incidence was higher between 1992 and 1995 (2.57/100 py), among cases with HIV co-infection (8.34/100 py) and among intravenous drug users (IDU) without methadone treatment (MT) during follow-up (6.66/100 py). The incidence rate of HCV seroconversion among cases with a history of IDU and current MT was 1.35/100 py, which is close to that of the total study population. The following variables had a positive predictive value for HCV infection: IDU (p<0.001; HR = 7,30; CI: 4.83-11.04), Spanish ethnicity (p = 0.009; HR = 2,03; CI: 1.93-3.44) and HIV infection (p = 0.015; HR = 1.97; CI: 1.14-3.39).<h4>Conclusion</h4>The incidence of HCV infection among prisoners was higher during the first part of the study and among IDU during the entire study period. Preventative programs should be directed toward this sub-group of the prison population.Andrés MarcoCarlos GallegoJoan A CaylàPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 2, p e90560 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Andrés Marco Carlos Gallego Joan A Caylà Incidence of hepatitis C infection among prisoners by routine laboratory values during a 20-year period.
description	<h4>Background</h4>To estimate the incidence of Hepatitis C virus (HCV) and the predictive factors through repeated routine laboratory analyses.<h4>Methods</h4>An observational cohort study was carried out in Quatre Camins Prison, Barcelona. The study included subjects with an initial negative HCV result and routine laboratory analyses containing HCV serology from 1992 to 2011. The incidence of infection was calculated for the study population and for sub-groups by 100 person-years of follow-up (100 py). The predictive factors were determined through Kaplan-Meier curves and a Cox regression. Hazard ratios (HR) and 95% confidence intervals (CI) were calculated.<h4>Results</h4>A total of 2,377 prisoners were included with a median follow-up time of 1,540.9 days per patient. Among the total population, 117 HCV seroconversions were detected (incidence of 1.17/100 py). The incidence was higher between 1992 and 1995 (2.57/100 py), among cases with HIV co-infection (8.34/100 py) and among intravenous drug users (IDU) without methadone treatment (MT) during follow-up (6.66/100 py). The incidence rate of HCV seroconversion among cases with a history of IDU and current MT was 1.35/100 py, which is close to that of the total study population. The following variables had a positive predictive value for HCV infection: IDU (p<0.001; HR = 7,30; CI: 4.83-11.04), Spanish ethnicity (p = 0.009; HR = 2,03; CI: 1.93-3.44) and HIV infection (p = 0.015; HR = 1.97; CI: 1.14-3.39).<h4>Conclusion</h4>The incidence of HCV infection among prisoners was higher during the first part of the study and among IDU during the entire study period. Preventative programs should be directed toward this sub-group of the prison population.
format	article
author	Andrés Marco Carlos Gallego Joan A Caylà
author_facet	Andrés Marco Carlos Gallego Joan A Caylà
author_sort	Andrés Marco
title	Incidence of hepatitis C infection among prisoners by routine laboratory values during a 20-year period.
title_short	Incidence of hepatitis C infection among prisoners by routine laboratory values during a 20-year period.
title_full	Incidence of hepatitis C infection among prisoners by routine laboratory values during a 20-year period.
title_fullStr	Incidence of hepatitis C infection among prisoners by routine laboratory values during a 20-year period.
title_full_unstemmed	Incidence of hepatitis C infection among prisoners by routine laboratory values during a 20-year period.
title_sort	incidence of hepatitis c infection among prisoners by routine laboratory values during a 20-year period.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/8dbaa3cfdd8042adabdfff8c27e68b95
work_keys_str_mv	AT andresmarco incidenceofhepatitiscinfectionamongprisonersbyroutinelaboratoryvaluesduringa20yearperiod AT carlosgallego incidenceofhepatitiscinfectionamongprisonersbyroutinelaboratoryvaluesduringa20yearperiod AT joanacayla incidenceofhepatitiscinfectionamongprisonersbyroutinelaboratoryvaluesduringa20yearperiod
_version_	1718421696087588864

Incidence of hepatitis C infection among prisoners by routine laboratory values during a 20-year period.

Ejemplares similares