Age-related changes in the peripheral retinal nerve fiber layer thickness

Gözde Hondur,1,2 Emre Göktaş,1 Lama Al-Aswad,1 Gülgün Tezel1 1Department of Ophthalmology, Columbia University, College of Physicians and Surgeons, New York, NY, USA; 2Department of Ophthalmology, Ulucanlar Training and Research Hospital, Ankara, Turkey Purpose:...

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Autores principales:	Hondur G, Göktaş E, Al-Aswad L, Tezel G
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	age glaucoma retinal nerve fiber layer thickness swept-source optical coherence tomography Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/8dbedfd7f4e844419359b5667bf89e35
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spelling	oai:doaj.org-article:8dbedfd7f4e844419359b5667bf89e352021-12-02T05:19:57ZAge-related changes in the peripheral retinal nerve fiber layer thickness1177-5483https://doaj.org/article/8dbedfd7f4e844419359b5667bf89e352018-02-01T00:00:00Zhttps://www.dovepress.com/age-related-changes-in-the-peripheral-retinal-nerve-fiber-layer-thickn-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Gözde Hondur,1,2 Emre Göktaş,1 Lama Al-Aswad,1 Gülgün Tezel1 1Department of Ophthalmology, Columbia University, College of Physicians and Surgeons, New York, NY, USA; 2Department of Ophthalmology, Ulucanlar Training and Research Hospital, Ankara, Turkey Purpose: This pilot cross-sectional study aimed to determine age-related changes of the retinal nerve fiber layer (RNFL) thickness in retinal periphery by swept-source optical coherence tomography-based analysis.Methods: Forty eyes of 40 healthy subjects were studied in three age groups, group 1 (20–40 years, n=15), group 2 (41–60 years, n=14), and group 3 (≥61 years, n=11). Wide-angle swept-source optical coherence tomography scans, including the optic disc and macula, were montaged with the nasal peripheral optical coherence tomography images acquired with a contralateral gaze. The peripapillary and peripheral RNFL thickness values were obtained for nasal and temporal sides. The ratio of peripheral-to-peripapillary RNFL thickness was also calculated for these sectors.Results: We detected a significantly thinner RNFL in older than younger subjects at a distance of 6 mm from the optic disc on nasal and temporal sides (P<0.001). An age-related reduction in peripheral-to-peripapillary RNFL thickness ratios (P<0.001 and P<0.02 for nasal and temporal sides, respectively) was also detected.Conclusion: The age-related decline should be taken into consideration when determining the glaucoma-related alterations in peripheral RNFL thickness. Continued analysis in patients with ocular hypertension and glaucoma should help determine whether RNFL in the periphery with lower nerve tissue reserve might be more susceptible to injury, whether injury to the peripheral RNFL might be easier to detect, and/or whether analysis of the peripheral RNFL thickness could improve clinical diagnosis and follow-up of glaucoma. Keywords: age, glaucoma, retinal nerve fiber layer thickness, swept-source optical coherence tomographyHondur GGöktaş EAl-Aswad LTezel GDove Medical Pressarticleageglaucomaretinal nerve fiber layer thicknessswept-source optical coherence tomographyOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 401-409 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	age glaucoma retinal nerve fiber layer thickness swept-source optical coherence tomography Ophthalmology RE1-994
spellingShingle	age glaucoma retinal nerve fiber layer thickness swept-source optical coherence tomography Ophthalmology RE1-994 Hondur G Göktaş E Al-Aswad L Tezel G Age-related changes in the peripheral retinal nerve fiber layer thickness
description	Gözde Hondur,1,2 Emre Göktaş,1 Lama Al-Aswad,1 Gülgün Tezel1 1Department of Ophthalmology, Columbia University, College of Physicians and Surgeons, New York, NY, USA; 2Department of Ophthalmology, Ulucanlar Training and Research Hospital, Ankara, Turkey Purpose: This pilot cross-sectional study aimed to determine age-related changes of the retinal nerve fiber layer (RNFL) thickness in retinal periphery by swept-source optical coherence tomography-based analysis.Methods: Forty eyes of 40 healthy subjects were studied in three age groups, group 1 (20–40 years, n=15), group 2 (41–60 years, n=14), and group 3 (≥61 years, n=11). Wide-angle swept-source optical coherence tomography scans, including the optic disc and macula, were montaged with the nasal peripheral optical coherence tomography images acquired with a contralateral gaze. The peripapillary and peripheral RNFL thickness values were obtained for nasal and temporal sides. The ratio of peripheral-to-peripapillary RNFL thickness was also calculated for these sectors.Results: We detected a significantly thinner RNFL in older than younger subjects at a distance of 6 mm from the optic disc on nasal and temporal sides (P<0.001). An age-related reduction in peripheral-to-peripapillary RNFL thickness ratios (P<0.001 and P<0.02 for nasal and temporal sides, respectively) was also detected.Conclusion: The age-related decline should be taken into consideration when determining the glaucoma-related alterations in peripheral RNFL thickness. Continued analysis in patients with ocular hypertension and glaucoma should help determine whether RNFL in the periphery with lower nerve tissue reserve might be more susceptible to injury, whether injury to the peripheral RNFL might be easier to detect, and/or whether analysis of the peripheral RNFL thickness could improve clinical diagnosis and follow-up of glaucoma. Keywords: age, glaucoma, retinal nerve fiber layer thickness, swept-source optical coherence tomography
format	article
author	Hondur G Göktaş E Al-Aswad L Tezel G
author_facet	Hondur G Göktaş E Al-Aswad L Tezel G
author_sort	Hondur G
title	Age-related changes in the peripheral retinal nerve fiber layer thickness
title_short	Age-related changes in the peripheral retinal nerve fiber layer thickness
title_full	Age-related changes in the peripheral retinal nerve fiber layer thickness
title_fullStr	Age-related changes in the peripheral retinal nerve fiber layer thickness
title_full_unstemmed	Age-related changes in the peripheral retinal nerve fiber layer thickness
title_sort	age-related changes in the peripheral retinal nerve fiber layer thickness
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/8dbedfd7f4e844419359b5667bf89e35
work_keys_str_mv	AT hondurg agerelatedchangesintheperipheralretinalnervefiberlayerthickness AT goktase agerelatedchangesintheperipheralretinalnervefiberlayerthickness AT alaswadl agerelatedchangesintheperipheralretinalnervefiberlayerthickness AT tezelg agerelatedchangesintheperipheralretinalnervefiberlayerthickness
_version_	1718400482907521024

Age-related changes in the peripheral retinal nerve fiber layer thickness

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