Metabolomics to Diagnose Oxidative Stress in Perinatal Asphyxia: Towards a Non-Invasive Approach

There is a need for feasible and non-invasive diagnostics in perinatal asphyxia. Metabolomics is the study of small molecular weight products of cellular metabolism that may, directly and indirectly, reflect the level of oxidative stress. Saliva analysis is a novel approach that has a yet unexplored...

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Autores principales:	Anne Lee Solevåg, Svetlana N. Zykova, Per Medbøe Thorsby, Georg M. Schmölzer
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	asphyxia neonatorum non-invasive diagnostics metabolomics oxidative stress saliva Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/8dc15b2f4d344421b82c1f734485cd5a
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spelling	oai:doaj.org-article:8dc15b2f4d344421b82c1f734485cd5a2021-11-25T16:27:52ZMetabolomics to Diagnose Oxidative Stress in Perinatal Asphyxia: Towards a Non-Invasive Approach10.3390/antiox101117532076-3921https://doaj.org/article/8dc15b2f4d344421b82c1f734485cd5a2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1753https://doaj.org/toc/2076-3921There is a need for feasible and non-invasive diagnostics in perinatal asphyxia. Metabolomics is the study of small molecular weight products of cellular metabolism that may, directly and indirectly, reflect the level of oxidative stress. Saliva analysis is a novel approach that has a yet unexplored potential in metabolomics in perinatal asphyxia. The aim of this review was to give an overview of metabolomics studies of oxidative stress in perinatal asphyxia, particularly searching for studies analyzing non-invasively collected biofluids including saliva. We searched the databases PubMed/Medline and included 11 original human and 4 animal studies. In perinatal asphyxia, whole blood, plasma, and urine are the most frequently used biofluids used for metabolomics analyses. Although changes in oxidative stress-related salivary metabolites have been reported in adults, the utility of this approach in perinatal asphyxia has not yet been explored. Human and animal studies indicate that, in addition to antioxidant enzymes, succinate and hypoxanthine, as well acylcarnitines may have discriminatory diagnostic and prognostic properties in perinatal asphyxia. Researchers may utilize the accumulating evidence of discriminatory metabolic patterns in perinatal asphyxia to develop bedside methods to measure oxidative stress metabolites in perinatal asphyxia. Although only supported by indirect evidence, saliva might be a candidate biofluid for such point-of-care diagnostics.Anne Lee SolevågSvetlana N. ZykovaPer Medbøe ThorsbyGeorg M. SchmölzerMDPI AGarticleasphyxia neonatorumnon-invasive diagnosticsmetabolomicsoxidative stresssalivaTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1753, p 1753 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	asphyxia neonatorum non-invasive diagnostics metabolomics oxidative stress saliva Therapeutics. Pharmacology RM1-950
spellingShingle	asphyxia neonatorum non-invasive diagnostics metabolomics oxidative stress saliva Therapeutics. Pharmacology RM1-950 Anne Lee Solevåg Svetlana N. Zykova Per Medbøe Thorsby Georg M. Schmölzer Metabolomics to Diagnose Oxidative Stress in Perinatal Asphyxia: Towards a Non-Invasive Approach
description	There is a need for feasible and non-invasive diagnostics in perinatal asphyxia. Metabolomics is the study of small molecular weight products of cellular metabolism that may, directly and indirectly, reflect the level of oxidative stress. Saliva analysis is a novel approach that has a yet unexplored potential in metabolomics in perinatal asphyxia. The aim of this review was to give an overview of metabolomics studies of oxidative stress in perinatal asphyxia, particularly searching for studies analyzing non-invasively collected biofluids including saliva. We searched the databases PubMed/Medline and included 11 original human and 4 animal studies. In perinatal asphyxia, whole blood, plasma, and urine are the most frequently used biofluids used for metabolomics analyses. Although changes in oxidative stress-related salivary metabolites have been reported in adults, the utility of this approach in perinatal asphyxia has not yet been explored. Human and animal studies indicate that, in addition to antioxidant enzymes, succinate and hypoxanthine, as well acylcarnitines may have discriminatory diagnostic and prognostic properties in perinatal asphyxia. Researchers may utilize the accumulating evidence of discriminatory metabolic patterns in perinatal asphyxia to develop bedside methods to measure oxidative stress metabolites in perinatal asphyxia. Although only supported by indirect evidence, saliva might be a candidate biofluid for such point-of-care diagnostics.
format	article
author	Anne Lee Solevåg Svetlana N. Zykova Per Medbøe Thorsby Georg M. Schmölzer
author_facet	Anne Lee Solevåg Svetlana N. Zykova Per Medbøe Thorsby Georg M. Schmölzer
author_sort	Anne Lee Solevåg
title	Metabolomics to Diagnose Oxidative Stress in Perinatal Asphyxia: Towards a Non-Invasive Approach
title_short	Metabolomics to Diagnose Oxidative Stress in Perinatal Asphyxia: Towards a Non-Invasive Approach
title_full	Metabolomics to Diagnose Oxidative Stress in Perinatal Asphyxia: Towards a Non-Invasive Approach
title_fullStr	Metabolomics to Diagnose Oxidative Stress in Perinatal Asphyxia: Towards a Non-Invasive Approach
title_full_unstemmed	Metabolomics to Diagnose Oxidative Stress in Perinatal Asphyxia: Towards a Non-Invasive Approach
title_sort	metabolomics to diagnose oxidative stress in perinatal asphyxia: towards a non-invasive approach
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8dc15b2f4d344421b82c1f734485cd5a
work_keys_str_mv	AT anneleesolevag metabolomicstodiagnoseoxidativestressinperinatalasphyxiatowardsanoninvasiveapproach AT svetlananzykova metabolomicstodiagnoseoxidativestressinperinatalasphyxiatowardsanoninvasiveapproach AT permedbøethorsby metabolomicstodiagnoseoxidativestressinperinatalasphyxiatowardsanoninvasiveapproach AT georgmschmolzer metabolomicstodiagnoseoxidativestressinperinatalasphyxiatowardsanoninvasiveapproach
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Metabolomics to Diagnose Oxidative Stress in Perinatal Asphyxia: Towards a Non-Invasive Approach

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