The metabolic enzyme fructose-1,6-bisphosphate aldolase acts as a transcriptional regulator in pathogenic Francisella

The metabolic enzyme fructose-1,6-bisphosphate aldolase acts as a transcriptional regulator in pathogenic Francisella

The enzyme fructose-bisphosphate aldolase (FBA) plays central roles in glycolysis and gluconeogenesis. Here, Ziveri et al. show that FBA of the pathogen Francisella novicida acts, in addition, as a transcriptional regulator and is important for bacterial multiplication in macrophages.

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Autores principales: Jason Ziveri, Fabiola Tros, Ida Chiara Guerrera, Cerina Chhuon, Mathilde Audry, Marion Dupuis, Monique Barel, Sarantis Korniotis, Simon Fillatreau, Lara Gales, Edern Cahoreau, Alain Charbit
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/8dc1a270813149de956d15a4be2abb18
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spelling oai:doaj.org-article:8dc1a270813149de956d15a4be2abb182021-12-02T14:42:41ZThe metabolic enzyme fructose-1,6-bisphosphate aldolase acts as a transcriptional regulator in pathogenic Francisella10.1038/s41467-017-00889-72041-1723https://doaj.org/article/8dc1a270813149de956d15a4be2abb182017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00889-7https://doaj.org/toc/2041-1723The enzyme fructose-bisphosphate aldolase (FBA) plays central roles in glycolysis and gluconeogenesis. Here, Ziveri et al. show that FBA of the pathogen Francisella novicida acts, in addition, as a transcriptional regulator and is important for bacterial multiplication in macrophages.Jason ZiveriFabiola TrosIda Chiara GuerreraCerina ChhuonMathilde AudryMarion DupuisMonique BarelSarantis KorniotisSimon FillatreauLara GalesEdern CahoreauAlain CharbitNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jason Ziveri
Fabiola Tros
Ida Chiara Guerrera
Cerina Chhuon
Mathilde Audry
Marion Dupuis
Monique Barel
Sarantis Korniotis
Simon Fillatreau
Lara Gales
Edern Cahoreau
Alain Charbit
The metabolic enzyme fructose-1,6-bisphosphate aldolase acts as a transcriptional regulator in pathogenic Francisella
description The enzyme fructose-bisphosphate aldolase (FBA) plays central roles in glycolysis and gluconeogenesis. Here, Ziveri et al. show that FBA of the pathogen Francisella novicida acts, in addition, as a transcriptional regulator and is important for bacterial multiplication in macrophages.
format article
author Jason Ziveri
Fabiola Tros
Ida Chiara Guerrera
Cerina Chhuon
Mathilde Audry
Marion Dupuis
Monique Barel
Sarantis Korniotis
Simon Fillatreau
Lara Gales
Edern Cahoreau
Alain Charbit
author_facet Jason Ziveri
Fabiola Tros
Ida Chiara Guerrera
Cerina Chhuon
Mathilde Audry
Marion Dupuis
Monique Barel
Sarantis Korniotis
Simon Fillatreau
Lara Gales
Edern Cahoreau
Alain Charbit
author_sort Jason Ziveri
title The metabolic enzyme fructose-1,6-bisphosphate aldolase acts as a transcriptional regulator in pathogenic Francisella
title_short The metabolic enzyme fructose-1,6-bisphosphate aldolase acts as a transcriptional regulator in pathogenic Francisella
title_full The metabolic enzyme fructose-1,6-bisphosphate aldolase acts as a transcriptional regulator in pathogenic Francisella
title_fullStr The metabolic enzyme fructose-1,6-bisphosphate aldolase acts as a transcriptional regulator in pathogenic Francisella
title_full_unstemmed The metabolic enzyme fructose-1,6-bisphosphate aldolase acts as a transcriptional regulator in pathogenic Francisella
title_sort metabolic enzyme fructose-1,6-bisphosphate aldolase acts as a transcriptional regulator in pathogenic francisella
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/8dc1a270813149de956d15a4be2abb18
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