Integrative transcriptome and chromatin landscape analysis reveals distinct epigenetic regulations in human memory B cells

Human memory B cells differentiate from naïve B cells and can express different immunoglobulin (Ig) isotypes resulted from class-switch recombination. Here the authors describe, using transcriptional and epigenetic data from human memory B cells and integrated multi-omics analyses, the differentiati...

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Autores principales:	Justin B. Moroney, Anusha Vasudev, Alexander Pertsemlidis, Hong Zan, Paolo Casali
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8dc242c2cd11471ba22d1bd0b6388cf5
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spelling	oai:doaj.org-article:8dc242c2cd11471ba22d1bd0b6388cf52021-12-02T15:37:12ZIntegrative transcriptome and chromatin landscape analysis reveals distinct epigenetic regulations in human memory B cells10.1038/s41467-020-19242-62041-1723https://doaj.org/article/8dc242c2cd11471ba22d1bd0b6388cf52020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19242-6https://doaj.org/toc/2041-1723Human memory B cells differentiate from naïve B cells and can express different immunoglobulin (Ig) isotypes resulted from class-switch recombination. Here the authors describe, using transcriptional and epigenetic data from human memory B cells and integrated multi-omics analyses, the differentiation regulation and trajectory of IgG+, IgA+ and IgD+ memory B cells.Justin B. MoroneyAnusha VasudevAlexander PertsemlidisHong ZanPaolo CasaliNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Justin B. Moroney Anusha Vasudev Alexander Pertsemlidis Hong Zan Paolo Casali Integrative transcriptome and chromatin landscape analysis reveals distinct epigenetic regulations in human memory B cells
description	Human memory B cells differentiate from naïve B cells and can express different immunoglobulin (Ig) isotypes resulted from class-switch recombination. Here the authors describe, using transcriptional and epigenetic data from human memory B cells and integrated multi-omics analyses, the differentiation regulation and trajectory of IgG+, IgA+ and IgD+ memory B cells.
format	article
author	Justin B. Moroney Anusha Vasudev Alexander Pertsemlidis Hong Zan Paolo Casali
author_facet	Justin B. Moroney Anusha Vasudev Alexander Pertsemlidis Hong Zan Paolo Casali
author_sort	Justin B. Moroney
title	Integrative transcriptome and chromatin landscape analysis reveals distinct epigenetic regulations in human memory B cells
title_short	Integrative transcriptome and chromatin landscape analysis reveals distinct epigenetic regulations in human memory B cells
title_full	Integrative transcriptome and chromatin landscape analysis reveals distinct epigenetic regulations in human memory B cells
title_fullStr	Integrative transcriptome and chromatin landscape analysis reveals distinct epigenetic regulations in human memory B cells
title_full_unstemmed	Integrative transcriptome and chromatin landscape analysis reveals distinct epigenetic regulations in human memory B cells
title_sort	integrative transcriptome and chromatin landscape analysis reveals distinct epigenetic regulations in human memory b cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8dc242c2cd11471ba22d1bd0b6388cf5
work_keys_str_mv	AT justinbmoroney integrativetranscriptomeandchromatinlandscapeanalysisrevealsdistinctepigeneticregulationsinhumanmemorybcells AT anushavasudev integrativetranscriptomeandchromatinlandscapeanalysisrevealsdistinctepigeneticregulationsinhumanmemorybcells AT alexanderpertsemlidis integrativetranscriptomeandchromatinlandscapeanalysisrevealsdistinctepigeneticregulationsinhumanmemorybcells AT hongzan integrativetranscriptomeandchromatinlandscapeanalysisrevealsdistinctepigeneticregulationsinhumanmemorybcells AT paolocasali integrativetranscriptomeandchromatinlandscapeanalysisrevealsdistinctepigeneticregulationsinhumanmemorybcells
_version_	1718386245431721984

Integrative transcriptome and chromatin landscape analysis reveals distinct epigenetic regulations in human memory B cells

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