Network analysis of the immune state of mice

Abstract The mammalian immune system protects individuals from infection and disease. It is a complex system of interacting cells and molecules, which has been studied extensively to investigate its detailed function, principally using laboratory mice. Despite the complexity of the immune system, it...

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Autores principales:	Elohim Fonseca dos Reis, Mark Viney, Naoki Masuda
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8dc3be9aa146494289f2879a324ca951
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spelling	oai:doaj.org-article:8dc3be9aa146494289f2879a324ca9512021-12-02T16:23:19ZNetwork analysis of the immune state of mice10.1038/s41598-021-83139-72045-2322https://doaj.org/article/8dc3be9aa146494289f2879a324ca9512021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83139-7https://doaj.org/toc/2045-2322Abstract The mammalian immune system protects individuals from infection and disease. It is a complex system of interacting cells and molecules, which has been studied extensively to investigate its detailed function, principally using laboratory mice. Despite the complexity of the immune system, it is often analysed using a restricted set of immunological parameters. Here we have sought to generate a system-wide view of the murine immune response, which we have done by undertaking a network analysis of 120 immune measures. To date, there has only been limited network analyses of the immune system. Our network analysis identified a relatively low number of communities of immune measure nodes. Some of these communities recapitulate the well-known T helper 1 vs. T helper 2 cytokine polarisation (where ordination analyses failed to do so), which validates the utility of our approach. Other communities we detected show apparently novel juxtapositions of immune nodes. We suggest that the structure of these other communities might represent functional immunological units, which may require further empirical investigation. These results show the utility of network analysis in understanding the functioning of the mammalian immune system.Elohim Fonseca dos ReisMark VineyNaoki MasudaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Elohim Fonseca dos Reis Mark Viney Naoki Masuda Network analysis of the immune state of mice
description	Abstract The mammalian immune system protects individuals from infection and disease. It is a complex system of interacting cells and molecules, which has been studied extensively to investigate its detailed function, principally using laboratory mice. Despite the complexity of the immune system, it is often analysed using a restricted set of immunological parameters. Here we have sought to generate a system-wide view of the murine immune response, which we have done by undertaking a network analysis of 120 immune measures. To date, there has only been limited network analyses of the immune system. Our network analysis identified a relatively low number of communities of immune measure nodes. Some of these communities recapitulate the well-known T helper 1 vs. T helper 2 cytokine polarisation (where ordination analyses failed to do so), which validates the utility of our approach. Other communities we detected show apparently novel juxtapositions of immune nodes. We suggest that the structure of these other communities might represent functional immunological units, which may require further empirical investigation. These results show the utility of network analysis in understanding the functioning of the mammalian immune system.
format	article
author	Elohim Fonseca dos Reis Mark Viney Naoki Masuda
author_facet	Elohim Fonseca dos Reis Mark Viney Naoki Masuda
author_sort	Elohim Fonseca dos Reis
title	Network analysis of the immune state of mice
title_short	Network analysis of the immune state of mice
title_full	Network analysis of the immune state of mice
title_fullStr	Network analysis of the immune state of mice
title_full_unstemmed	Network analysis of the immune state of mice
title_sort	network analysis of the immune state of mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8dc3be9aa146494289f2879a324ca951
work_keys_str_mv	AT elohimfonsecadosreis networkanalysisoftheimmunestateofmice AT markviney networkanalysisoftheimmunestateofmice AT naokimasuda networkanalysisoftheimmunestateofmice
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Network analysis of the immune state of mice

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