Seroepidemiology and associated risk factors of hepatitis B and C virus infections among pregnant women attending maternity wards at two hospitals in Swabi, Khyber Pakhtunkhwa, Pakistan.

<h4>Background & aim</h4>Hepatitis B and C infections are global issues that are associated with a massive financial burden in developing countries where vertical transmission is the major mode and remains high. This cross-sectional study was designed to investigate the seroepidemiol...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Muhammad Israr, Fawad Ali, Arif Nawaz, Muhammad Idrees, Aishma Khattak, Shafiq Ur Rehman, Azizullah Azizullah, Bashir Ahmad, Syeda Asma Bano, Rashid Iqbal
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8dcbb727dd954ebb812956f877156632
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8dcbb727dd954ebb812956f877156632
record_format	dspace
spelling	oai:doaj.org-article:8dcbb727dd954ebb812956f8771566322021-12-02T20:14:57ZSeroepidemiology and associated risk factors of hepatitis B and C virus infections among pregnant women attending maternity wards at two hospitals in Swabi, Khyber Pakhtunkhwa, Pakistan.1932-620310.1371/journal.pone.0255189https://doaj.org/article/8dcbb727dd954ebb812956f8771566322021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255189https://doaj.org/toc/1932-6203<h4>Background & aim</h4>Hepatitis B and C infections are global issues that are associated with a massive financial burden in developing countries where vertical transmission is the major mode and remains high. This cross-sectional study was designed to investigate the seroepidemiology and associated risk factors of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections among 375 pregnant women attending antenatal care health facilities at Bacha Khan Medical Complex (BKMC) Shahmansoor and District Head Quarter (DHQ) Hospital Swabi, Khyber Pakhtunkhwa, Pakistan.<h4>Methodology</h4>From a total of 375 pregnant women selected using systematic random sampling from both hospitals, 10 ml of blood samples were collected and alienated serum was examined for indicators identification through the Immuno-Chromatographic Test (ICT) and 3rd Generation Enzyme-Linked Immunosorbent Assay (ELISA). A pre-structured questionnaire was used to collect the socio-demographic data and possible risk factors. The data was analyzed via SPSS 23.0 statistical software. A chi-square analysis was performed to determine the association between variables. P-value < 0.05 was set statistically significant.<h4>Results</h4>The overall frequency of HBV and HCV among 375 pregnant women involved in the study was 3.7% and 2.1% respectively. None of the pregnant women were co-infected with HBV and HCV. Dental extraction (P = 0.001) and blood transfusion (P = 0.0005) were significantly allied with HBV infection while surgical procedure (P = 0.0001) was significantly associated with HCV infection. Moreover the sociodemographic characteristics: residential status (P = 0.017) and educational level (P = 0.048) were found significant risk factors of HBsAg and maternal age (P = 0.033) of anti-HCV, respectively.<h4>Conclusion & recommendation</h4>HBV and HCV infections are intermediary endemic in the study area. A higher prevalence of HBV was detected among pregnant mothers with a history of dental extraction, history of blood transfusion, resident to the urban area and low educational level. The age and surgical procedures were the potential risk factors found significantly associated with HCV positivity among pregnant mothers in our setup. Future negotiations to control vertical transmission should include routine antenatal screening for these infections early in pregnancy and the requirement of efficient preventive tools including the birth dose of the hepatitis B vaccine in combination with hepatitis B immune globulins to the neonate.Muhammad IsrarFawad AliArif NawazMuhammad IdreesAishma KhattakShafiq Ur RehmanAzizullah AzizullahBashir AhmadSyeda Asma BanoRashid IqbalPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0255189 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Muhammad Israr Fawad Ali Arif Nawaz Muhammad Idrees Aishma Khattak Shafiq Ur Rehman Azizullah Azizullah Bashir Ahmad Syeda Asma Bano Rashid Iqbal Seroepidemiology and associated risk factors of hepatitis B and C virus infections among pregnant women attending maternity wards at two hospitals in Swabi, Khyber Pakhtunkhwa, Pakistan.
description	<h4>Background & aim</h4>Hepatitis B and C infections are global issues that are associated with a massive financial burden in developing countries where vertical transmission is the major mode and remains high. This cross-sectional study was designed to investigate the seroepidemiology and associated risk factors of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections among 375 pregnant women attending antenatal care health facilities at Bacha Khan Medical Complex (BKMC) Shahmansoor and District Head Quarter (DHQ) Hospital Swabi, Khyber Pakhtunkhwa, Pakistan.<h4>Methodology</h4>From a total of 375 pregnant women selected using systematic random sampling from both hospitals, 10 ml of blood samples were collected and alienated serum was examined for indicators identification through the Immuno-Chromatographic Test (ICT) and 3rd Generation Enzyme-Linked Immunosorbent Assay (ELISA). A pre-structured questionnaire was used to collect the socio-demographic data and possible risk factors. The data was analyzed via SPSS 23.0 statistical software. A chi-square analysis was performed to determine the association between variables. P-value < 0.05 was set statistically significant.<h4>Results</h4>The overall frequency of HBV and HCV among 375 pregnant women involved in the study was 3.7% and 2.1% respectively. None of the pregnant women were co-infected with HBV and HCV. Dental extraction (P = 0.001) and blood transfusion (P = 0.0005) were significantly allied with HBV infection while surgical procedure (P = 0.0001) was significantly associated with HCV infection. Moreover the sociodemographic characteristics: residential status (P = 0.017) and educational level (P = 0.048) were found significant risk factors of HBsAg and maternal age (P = 0.033) of anti-HCV, respectively.<h4>Conclusion & recommendation</h4>HBV and HCV infections are intermediary endemic in the study area. A higher prevalence of HBV was detected among pregnant mothers with a history of dental extraction, history of blood transfusion, resident to the urban area and low educational level. The age and surgical procedures were the potential risk factors found significantly associated with HCV positivity among pregnant mothers in our setup. Future negotiations to control vertical transmission should include routine antenatal screening for these infections early in pregnancy and the requirement of efficient preventive tools including the birth dose of the hepatitis B vaccine in combination with hepatitis B immune globulins to the neonate.
format	article
author	Muhammad Israr Fawad Ali Arif Nawaz Muhammad Idrees Aishma Khattak Shafiq Ur Rehman Azizullah Azizullah Bashir Ahmad Syeda Asma Bano Rashid Iqbal
author_facet	Muhammad Israr Fawad Ali Arif Nawaz Muhammad Idrees Aishma Khattak Shafiq Ur Rehman Azizullah Azizullah Bashir Ahmad Syeda Asma Bano Rashid Iqbal
author_sort	Muhammad Israr
title	Seroepidemiology and associated risk factors of hepatitis B and C virus infections among pregnant women attending maternity wards at two hospitals in Swabi, Khyber Pakhtunkhwa, Pakistan.
title_short	Seroepidemiology and associated risk factors of hepatitis B and C virus infections among pregnant women attending maternity wards at two hospitals in Swabi, Khyber Pakhtunkhwa, Pakistan.
title_full	Seroepidemiology and associated risk factors of hepatitis B and C virus infections among pregnant women attending maternity wards at two hospitals in Swabi, Khyber Pakhtunkhwa, Pakistan.
title_fullStr	Seroepidemiology and associated risk factors of hepatitis B and C virus infections among pregnant women attending maternity wards at two hospitals in Swabi, Khyber Pakhtunkhwa, Pakistan.
title_full_unstemmed	Seroepidemiology and associated risk factors of hepatitis B and C virus infections among pregnant women attending maternity wards at two hospitals in Swabi, Khyber Pakhtunkhwa, Pakistan.
title_sort	seroepidemiology and associated risk factors of hepatitis b and c virus infections among pregnant women attending maternity wards at two hospitals in swabi, khyber pakhtunkhwa, pakistan.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/8dcbb727dd954ebb812956f877156632
work_keys_str_mv	AT muhammadisrar seroepidemiologyandassociatedriskfactorsofhepatitisbandcvirusinfectionsamongpregnantwomenattendingmaternitywardsattwohospitalsinswabikhyberpakhtunkhwapakistan AT fawadali seroepidemiologyandassociatedriskfactorsofhepatitisbandcvirusinfectionsamongpregnantwomenattendingmaternitywardsattwohospitalsinswabikhyberpakhtunkhwapakistan AT arifnawaz seroepidemiologyandassociatedriskfactorsofhepatitisbandcvirusinfectionsamongpregnantwomenattendingmaternitywardsattwohospitalsinswabikhyberpakhtunkhwapakistan AT muhammadidrees seroepidemiologyandassociatedriskfactorsofhepatitisbandcvirusinfectionsamongpregnantwomenattendingmaternitywardsattwohospitalsinswabikhyberpakhtunkhwapakistan AT aishmakhattak seroepidemiologyandassociatedriskfactorsofhepatitisbandcvirusinfectionsamongpregnantwomenattendingmaternitywardsattwohospitalsinswabikhyberpakhtunkhwapakistan AT shafiqurrehman seroepidemiologyandassociatedriskfactorsofhepatitisbandcvirusinfectionsamongpregnantwomenattendingmaternitywardsattwohospitalsinswabikhyberpakhtunkhwapakistan AT azizullahazizullah seroepidemiologyandassociatedriskfactorsofhepatitisbandcvirusinfectionsamongpregnantwomenattendingmaternitywardsattwohospitalsinswabikhyberpakhtunkhwapakistan AT bashirahmad seroepidemiologyandassociatedriskfactorsofhepatitisbandcvirusinfectionsamongpregnantwomenattendingmaternitywardsattwohospitalsinswabikhyberpakhtunkhwapakistan AT syedaasmabano seroepidemiologyandassociatedriskfactorsofhepatitisbandcvirusinfectionsamongpregnantwomenattendingmaternitywardsattwohospitalsinswabikhyberpakhtunkhwapakistan AT rashidiqbal seroepidemiologyandassociatedriskfactorsofhepatitisbandcvirusinfectionsamongpregnantwomenattendingmaternitywardsattwohospitalsinswabikhyberpakhtunkhwapakistan
_version_	1718374658964717568

Seroepidemiology and associated risk factors of hepatitis B and C virus infections among pregnant women attending maternity wards at two hospitals in Swabi, Khyber Pakhtunkhwa, Pakistan.

Ejemplares similares