Interaction of hydrophobic polymers with model lipid bilayers

Abstract The interaction of nanoscale synthetic materials with cell membranes is one of the key steps determining nanomaterials’ toxicity. Here we use molecular simulations, with atomistic and coarse-grained resolution, to investigate the interaction of three hydrophobic polymers with model lipid me...

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Autores principales:	D. Bochicchio, E. Panizon, L. Monticelli, G. Rossi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8dcfa2983fdd44afbfa51c31826b2e9c
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spelling	oai:doaj.org-article:8dcfa2983fdd44afbfa51c31826b2e9c2021-12-02T16:06:03ZInteraction of hydrophobic polymers with model lipid bilayers10.1038/s41598-017-06668-02045-2322https://doaj.org/article/8dcfa2983fdd44afbfa51c31826b2e9c2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06668-0https://doaj.org/toc/2045-2322Abstract The interaction of nanoscale synthetic materials with cell membranes is one of the key steps determining nanomaterials’ toxicity. Here we use molecular simulations, with atomistic and coarse-grained resolution, to investigate the interaction of three hydrophobic polymers with model lipid membranes. Polymer nanoparticles made of polyethylene (PE), polypropylene (PP) and polystyrene with size up to 7 nm enter easily POPC lipid membranes, localizing to the membrane hydrophobic core. For all three materials, solid polymeric nanoparticles become essentially liquid within the membrane at room temperature. Still, their behavior in the membrane core is not the same: PP and PS disperse in the core of the bilayer, while PE shows a tendency to aggregate. We also examined the interaction of the polymers with heterogeneous membranes, consisting of a ternary lipid mixture exhibiting liquid-ordered/liquid-disordered phase separation. The behavior of the three polymers is markedly different: PP disfavors lipid phase separation, PS stabilizes it, and PE modifies the topology of the phase boundaries and causes cholesterol depletion from the liquid ordered phase. Our results show that different hydrophobic polymers have major effects on the properties of lipid membranes, calling for further investigations on model systems and cell membranes.D. BochicchioE. PanizonL. MonticelliG. RossiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q D. Bochicchio E. Panizon L. Monticelli G. Rossi Interaction of hydrophobic polymers with model lipid bilayers
description	Abstract The interaction of nanoscale synthetic materials with cell membranes is one of the key steps determining nanomaterials’ toxicity. Here we use molecular simulations, with atomistic and coarse-grained resolution, to investigate the interaction of three hydrophobic polymers with model lipid membranes. Polymer nanoparticles made of polyethylene (PE), polypropylene (PP) and polystyrene with size up to 7 nm enter easily POPC lipid membranes, localizing to the membrane hydrophobic core. For all three materials, solid polymeric nanoparticles become essentially liquid within the membrane at room temperature. Still, their behavior in the membrane core is not the same: PP and PS disperse in the core of the bilayer, while PE shows a tendency to aggregate. We also examined the interaction of the polymers with heterogeneous membranes, consisting of a ternary lipid mixture exhibiting liquid-ordered/liquid-disordered phase separation. The behavior of the three polymers is markedly different: PP disfavors lipid phase separation, PS stabilizes it, and PE modifies the topology of the phase boundaries and causes cholesterol depletion from the liquid ordered phase. Our results show that different hydrophobic polymers have major effects on the properties of lipid membranes, calling for further investigations on model systems and cell membranes.
format	article
author	D. Bochicchio E. Panizon L. Monticelli G. Rossi
author_facet	D. Bochicchio E. Panizon L. Monticelli G. Rossi
author_sort	D. Bochicchio
title	Interaction of hydrophobic polymers with model lipid bilayers
title_short	Interaction of hydrophobic polymers with model lipid bilayers
title_full	Interaction of hydrophobic polymers with model lipid bilayers
title_fullStr	Interaction of hydrophobic polymers with model lipid bilayers
title_full_unstemmed	Interaction of hydrophobic polymers with model lipid bilayers
title_sort	interaction of hydrophobic polymers with model lipid bilayers
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8dcfa2983fdd44afbfa51c31826b2e9c
work_keys_str_mv	AT dbochicchio interactionofhydrophobicpolymerswithmodellipidbilayers AT epanizon interactionofhydrophobicpolymerswithmodellipidbilayers AT lmonticelli interactionofhydrophobicpolymerswithmodellipidbilayers AT grossi interactionofhydrophobicpolymerswithmodellipidbilayers
_version_	1718385160959819776

Interaction of hydrophobic polymers with model lipid bilayers

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