A shared Runx1-bound Zbtb16 enhancer directs innate and innate-like lymphoid lineage development

Zbtb16-encoded transcription factor PLZF directs the differentiation of multiple innate and innate-like cell lineages, but how Zbtb16 itself is regulated remains unclear. Here the authors show, using CRISPR gene editing, ATAC-seq and ChIP-seq, that specific Runx1-bound enhancer elements critically m...

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Autores principales:	Ai-Ping Mao, Isabel E. Ishizuka, Darshan N. Kasal, Malay Mandal, Albert Bendelac
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8dd0fcd1a0814b67b951e8f0ed19db10
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spelling	oai:doaj.org-article:8dd0fcd1a0814b67b951e8f0ed19db102021-12-02T14:40:32ZA shared Runx1-bound Zbtb16 enhancer directs innate and innate-like lymphoid lineage development10.1038/s41467-017-00882-02041-1723https://doaj.org/article/8dd0fcd1a0814b67b951e8f0ed19db102017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00882-0https://doaj.org/toc/2041-1723Zbtb16-encoded transcription factor PLZF directs the differentiation of multiple innate and innate-like cell lineages, but how Zbtb16 itself is regulated remains unclear. Here the authors show, using CRISPR gene editing, ATAC-seq and ChIP-seq, that specific Runx1-bound enhancer elements critically modulate lineage-dependent expressions of PLZF.Ai-Ping MaoIsabel E. IshizukaDarshan N. KasalMalay MandalAlbert BendelacNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ai-Ping Mao Isabel E. Ishizuka Darshan N. Kasal Malay Mandal Albert Bendelac A shared Runx1-bound Zbtb16 enhancer directs innate and innate-like lymphoid lineage development
description	Zbtb16-encoded transcription factor PLZF directs the differentiation of multiple innate and innate-like cell lineages, but how Zbtb16 itself is regulated remains unclear. Here the authors show, using CRISPR gene editing, ATAC-seq and ChIP-seq, that specific Runx1-bound enhancer elements critically modulate lineage-dependent expressions of PLZF.
format	article
author	Ai-Ping Mao Isabel E. Ishizuka Darshan N. Kasal Malay Mandal Albert Bendelac
author_facet	Ai-Ping Mao Isabel E. Ishizuka Darshan N. Kasal Malay Mandal Albert Bendelac
author_sort	Ai-Ping Mao
title	A shared Runx1-bound Zbtb16 enhancer directs innate and innate-like lymphoid lineage development
title_short	A shared Runx1-bound Zbtb16 enhancer directs innate and innate-like lymphoid lineage development
title_full	A shared Runx1-bound Zbtb16 enhancer directs innate and innate-like lymphoid lineage development
title_fullStr	A shared Runx1-bound Zbtb16 enhancer directs innate and innate-like lymphoid lineage development
title_full_unstemmed	A shared Runx1-bound Zbtb16 enhancer directs innate and innate-like lymphoid lineage development
title_sort	shared runx1-bound zbtb16 enhancer directs innate and innate-like lymphoid lineage development
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8dd0fcd1a0814b67b951e8f0ed19db10
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A shared Runx1-bound Zbtb16 enhancer directs innate and innate-like lymphoid lineage development

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