A shared Runx1-bound Zbtb16 enhancer directs innate and innate-like lymphoid lineage development
Zbtb16-encoded transcription factor PLZF directs the differentiation of multiple innate and innate-like cell lineages, but how Zbtb16 itself is regulated remains unclear. Here the authors show, using CRISPR gene editing, ATAC-seq and ChIP-seq, that specific Runx1-bound enhancer elements critically m...
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Autores principales: | Ai-Ping Mao, Isabel E. Ishizuka, Darshan N. Kasal, Malay Mandal, Albert Bendelac |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
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Materias: | |
Acceso en línea: | https://doaj.org/article/8dd0fcd1a0814b67b951e8f0ed19db10 |
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