Metabolic factors associated with risk of renal cell carcinoma.
Previous studies have shown that obesity and hypertension are associated with increased risk of renal cell carcinoma (RCC), but less is known about the association to other metabolic factors. In the Metabolic Syndrome and Cancer project (Me-Can) data on body mass index (BMI, kg/m2), blood pressure,...
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2013
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oai:doaj.org-article:8dd1243da3554e2ba0d5cfb428ca68ba2021-11-18T07:55:31ZMetabolic factors associated with risk of renal cell carcinoma.1932-620310.1371/journal.pone.0057475https://doaj.org/article/8dd1243da3554e2ba0d5cfb428ca68ba2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23468995/?tool=EBIhttps://doaj.org/toc/1932-6203Previous studies have shown that obesity and hypertension are associated with increased risk of renal cell carcinoma (RCC), but less is known about the association to other metabolic factors. In the Metabolic Syndrome and Cancer project (Me-Can) data on body mass index (BMI, kg/m2), blood pressure, and circulating levels of glucose, cholesterol, and triglycerides were collected from 560,388 men and women in cohorts from Norway, Austria, and Sweden. By use of Cox proportional hazard models, hazard ratios (HR) were calculated for separate and composite metabolic exposures. During a median follow-up of 10 years, 592 men and 263 women were diagnosed with RCC. Among men, we found an increased risk of RCC for BMI, highest vs. lowest quintile, (HR = 1.51, 95% CI 1.13-2.03), systolic blood pressure, (HR = 3.40, 95% CI 1.91-6.06), diastolic blood pressure, (HR = 3.33, 95% CI 1.85-5.99), glucose, (HR = 3.75, 95% CI 1.46-9.68), triglycerides, (HR = 1.79, 95% CI 1.00-3.21) and a composite score of these metabolic factors, (HR = 2.68, 95% CI 1.75-4.11). Among women we found an increased risk of RCC for BMI, highest vs. lowest quintile, (HR = 2.21, 95% CI 1.32-3.70) and the composite score, (HR = 2.29, 95% CI 1.12-4.68). High levels of the composite score were also associated with risk of death from RCC among both men and women. No multiplicative statistical or biological interactions between metabolic factors on risk of RCC were found. High levels of BMI, blood pressure, glucose and triglycerides among men and high BMI among women were associated with increased risk of RCC.Christel HäggströmKilian RappTanja StocksJonas ManjerTone BjørgeHanno UlmerAnders EngelandMartin AlmqvistHans ConcinRandi SelmerBörje LjungbergSteinar TretliGabriele NagelGöran HallmansHåkan JonssonPär StattinPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 2, p e57475 (2013) |
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Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Christel Häggström Kilian Rapp Tanja Stocks Jonas Manjer Tone Bjørge Hanno Ulmer Anders Engeland Martin Almqvist Hans Concin Randi Selmer Börje Ljungberg Steinar Tretli Gabriele Nagel Göran Hallmans Håkan Jonsson Pär Stattin Metabolic factors associated with risk of renal cell carcinoma. |
| description |
Previous studies have shown that obesity and hypertension are associated with increased risk of renal cell carcinoma (RCC), but less is known about the association to other metabolic factors. In the Metabolic Syndrome and Cancer project (Me-Can) data on body mass index (BMI, kg/m2), blood pressure, and circulating levels of glucose, cholesterol, and triglycerides were collected from 560,388 men and women in cohorts from Norway, Austria, and Sweden. By use of Cox proportional hazard models, hazard ratios (HR) were calculated for separate and composite metabolic exposures. During a median follow-up of 10 years, 592 men and 263 women were diagnosed with RCC. Among men, we found an increased risk of RCC for BMI, highest vs. lowest quintile, (HR = 1.51, 95% CI 1.13-2.03), systolic blood pressure, (HR = 3.40, 95% CI 1.91-6.06), diastolic blood pressure, (HR = 3.33, 95% CI 1.85-5.99), glucose, (HR = 3.75, 95% CI 1.46-9.68), triglycerides, (HR = 1.79, 95% CI 1.00-3.21) and a composite score of these metabolic factors, (HR = 2.68, 95% CI 1.75-4.11). Among women we found an increased risk of RCC for BMI, highest vs. lowest quintile, (HR = 2.21, 95% CI 1.32-3.70) and the composite score, (HR = 2.29, 95% CI 1.12-4.68). High levels of the composite score were also associated with risk of death from RCC among both men and women. No multiplicative statistical or biological interactions between metabolic factors on risk of RCC were found. High levels of BMI, blood pressure, glucose and triglycerides among men and high BMI among women were associated with increased risk of RCC. |
| format |
article |
| author |
Christel Häggström Kilian Rapp Tanja Stocks Jonas Manjer Tone Bjørge Hanno Ulmer Anders Engeland Martin Almqvist Hans Concin Randi Selmer Börje Ljungberg Steinar Tretli Gabriele Nagel Göran Hallmans Håkan Jonsson Pär Stattin |
| author_facet |
Christel Häggström Kilian Rapp Tanja Stocks Jonas Manjer Tone Bjørge Hanno Ulmer Anders Engeland Martin Almqvist Hans Concin Randi Selmer Börje Ljungberg Steinar Tretli Gabriele Nagel Göran Hallmans Håkan Jonsson Pär Stattin |
| author_sort |
Christel Häggström |
| title |
Metabolic factors associated with risk of renal cell carcinoma. |
| title_short |
Metabolic factors associated with risk of renal cell carcinoma. |
| title_full |
Metabolic factors associated with risk of renal cell carcinoma. |
| title_fullStr |
Metabolic factors associated with risk of renal cell carcinoma. |
| title_full_unstemmed |
Metabolic factors associated with risk of renal cell carcinoma. |
| title_sort |
metabolic factors associated with risk of renal cell carcinoma. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/8dd1243da3554e2ba0d5cfb428ca68ba |
| work_keys_str_mv |
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