Surgery for Cutaneous Squamous Cell Carcinoma and its Limits in Advanced Disease

Surgery remains the first-line therapeutic option for most patients with cutaneous squamous cell carcinoma (cSCC). However, in the current therapeutic landscape, surgery must attempt to the complete tumor resection (R0 resection) with the lowest risk of surgical complications. This double aim is us...

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Autores principales:	David Moreno-Ramírez, Francisca Silva-Clavería, Almudena Fernández-Orland, Noemí Eiris, Andrés Ruiz-de-Casas, Lara Ferrándiz
Formato:	article
Lenguaje:	EN
Publicado:	Mattioli1885 2021
Materias:	cutaneous squamous cell carcinoma surgery oncologic surgery Mohs surgery nodal surgery nodal metastasis Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/8dd53df99b21490f8467b25c009d75f9
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spelling	oai:doaj.org-article:8dd53df99b21490f8467b25c009d75f92021-11-17T08:27:37ZSurgery for Cutaneous Squamous Cell Carcinoma and its Limits in Advanced Disease10.5826/dpc.11S2a167S2160-9381https://doaj.org/article/8dd53df99b21490f8467b25c009d75f92021-10-01T00:00:00Zhttp://dpcj.org/index.php/dpc/article/view/2040https://doaj.org/toc/2160-9381 Surgery remains the first-line therapeutic option for most patients with cutaneous squamous cell carcinoma (cSCC). However, in the current therapeutic landscape, surgery must attempt to the complete tumor resection (R0 resection) with the lowest risk of surgical complications. This double aim is usually accomplished through standard excision with clinical margins in patients with low-risk tumors or by some of the micrographically controlled surgery procedures for patients with tumors at high-risk of local recurrence and metastasis. Surgery is also a first-line treatment for nodal metastases of cSCC as well as an option to consider in patients who develop recurrences while receiving immunotherapy, or as a palliation procedure in patients with advanced tumors. Neoadjuvant immunotherapy, that is the use of a medical treatment before surgery, is under investigation in patients with cSCC. The decision-making process and guidelines recommendations regarding cSCC surgery are reviewed in this manuscript. David Moreno-RamírezFrancisca Silva-ClaveríaAlmudena Fernández-OrlandNoemí EirisAndrés Ruiz-de-CasasLara FerrándizMattioli1885articlecutaneous squamous cell carcinomasurgeryoncologic surgeryMohs surgerynodal surgerynodal metastasisDermatologyRL1-803ENDermatology Practical & Conceptual, Vol 11, Iss S2 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cutaneous squamous cell carcinoma surgery oncologic surgery Mohs surgery nodal surgery nodal metastasis Dermatology RL1-803
spellingShingle	cutaneous squamous cell carcinoma surgery oncologic surgery Mohs surgery nodal surgery nodal metastasis Dermatology RL1-803 David Moreno-Ramírez Francisca Silva-Clavería Almudena Fernández-Orland Noemí Eiris Andrés Ruiz-de-Casas Lara Ferrándiz Surgery for Cutaneous Squamous Cell Carcinoma and its Limits in Advanced Disease
description	Surgery remains the first-line therapeutic option for most patients with cutaneous squamous cell carcinoma (cSCC). However, in the current therapeutic landscape, surgery must attempt to the complete tumor resection (R0 resection) with the lowest risk of surgical complications. This double aim is usually accomplished through standard excision with clinical margins in patients with low-risk tumors or by some of the micrographically controlled surgery procedures for patients with tumors at high-risk of local recurrence and metastasis. Surgery is also a first-line treatment for nodal metastases of cSCC as well as an option to consider in patients who develop recurrences while receiving immunotherapy, or as a palliation procedure in patients with advanced tumors. Neoadjuvant immunotherapy, that is the use of a medical treatment before surgery, is under investigation in patients with cSCC. The decision-making process and guidelines recommendations regarding cSCC surgery are reviewed in this manuscript.
format	article
author	David Moreno-Ramírez Francisca Silva-Clavería Almudena Fernández-Orland Noemí Eiris Andrés Ruiz-de-Casas Lara Ferrándiz
author_facet	David Moreno-Ramírez Francisca Silva-Clavería Almudena Fernández-Orland Noemí Eiris Andrés Ruiz-de-Casas Lara Ferrándiz
author_sort	David Moreno-Ramírez
title	Surgery for Cutaneous Squamous Cell Carcinoma and its Limits in Advanced Disease
title_short	Surgery for Cutaneous Squamous Cell Carcinoma and its Limits in Advanced Disease
title_full	Surgery for Cutaneous Squamous Cell Carcinoma and its Limits in Advanced Disease
title_fullStr	Surgery for Cutaneous Squamous Cell Carcinoma and its Limits in Advanced Disease
title_full_unstemmed	Surgery for Cutaneous Squamous Cell Carcinoma and its Limits in Advanced Disease
title_sort	surgery for cutaneous squamous cell carcinoma and its limits in advanced disease
publisher	Mattioli1885
publishDate	2021
url	https://doaj.org/article/8dd53df99b21490f8467b25c009d75f9
work_keys_str_mv	AT davidmorenoramirez surgeryforcutaneoussquamouscellcarcinomaanditslimitsinadvanceddisease AT franciscasilvaclaveria surgeryforcutaneoussquamouscellcarcinomaanditslimitsinadvanceddisease AT almudenafernandezorland surgeryforcutaneoussquamouscellcarcinomaanditslimitsinadvanceddisease AT noemieiris surgeryforcutaneoussquamouscellcarcinomaanditslimitsinadvanceddisease AT andresruizdecasas surgeryforcutaneoussquamouscellcarcinomaanditslimitsinadvanceddisease AT laraferrandiz surgeryforcutaneoussquamouscellcarcinomaanditslimitsinadvanceddisease
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Surgery for Cutaneous Squamous Cell Carcinoma and its Limits in Advanced Disease

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