Comparative effects of the ω3 polyunsaturated fatty acid derivatives resolvins E1 and D1 and protectin DX in models of inflammation and pain

Comparative effects of the ω3 polyunsaturated fatty acid derivatives resolvins E1 and D1 and protectin DX in models of inflammation and pain

Flávia CS Fonseca,1 Ricardo M Orlando,2 Regina MM Turchetti-Maia,1 Janetti Nogueira de Francischi1 1Department of Pharmacology, Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; 2Department of Chemistry, Exact Sciences Institute, Fede...

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Autores principales: Fonseca FCS, Orlando RM, Turchetti-Maia RMM, Francischi JN
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2017
Materias:
resolvin E1
resolvin D1
protectin DX
edema
nociception
Pathology
RB1-214
Therapeutics. Pharmacology
RM1-950
Acceso en línea:https://doaj.org/article/8dd64199925c4c8f923a6d37d98d4726
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spelling oai:doaj.org-article:8dd64199925c4c8f923a6d37d98d47262021-12-02T02:55:23ZComparative effects of the ω3 polyunsaturated fatty acid derivatives resolvins E1 and D1 and protectin DX in models of inflammation and pain1178-7031https://doaj.org/article/8dd64199925c4c8f923a6d37d98d47262017-08-01T00:00:00Zhttps://www.dovepress.com/comparative-effects-of-the-omega-3-polyunsaturated-fatty-acid-derivati-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Flávia CS Fonseca,1 Ricardo M Orlando,2 Regina MM Turchetti-Maia,1 Janetti Nogueira de Francischi1 1Department of Pharmacology, Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; 2Department of Chemistry, Exact Sciences Institute, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil Purpose: Specialized pro-resolving lipid mediators (SPMs), also known as lipoxins, resolvins (Rvs), protectins and maresins, have been implicated in the resolution of the inflammatory process. However, a systematic comparison of their activity in the relief of inflammation and pain models is still lacking.Materials and methods: The effects of Rvs E1 and D1 and protectin DX (PDX) were assessed in rat paws inflamed by the standard proinflammatory stimulus carrageenan or by histamine, 5-hydroxytryptamine, substance P or prostaglandin E2. The experimental outcomes were the mechanical nociceptive threshold and increase in paw volume as a measure of pain and edema formation, respectively. The analgesic and anti-inflammatory activities of the indicated SPMs were also compared with nonsteroidal (indomethacin and celecoxib) and steroidal (dexamethasone) anti-inflammatory drugs.Results: Only RvE1 and RvD1 presented analgesic and anti-inflammatory activities in the carrageenan model, and RvE1 was twice as potent as RvD1. Both substances tended to be better analgesics than anti-inflammatory agents, with a modeling profile similar to steroidal anti-inflammatory drugs. However, proinflammatory effects (edema formation) were also detected when the mediators histamine, 5-hydroxytryptamine or substance P replaced carrageenan as the proinflammatory stimuli. The analgesic and anti-inflammatory effects of resolvins were specifically prevented by an antagonist of the leukotriene B4 receptor 1 (BLT1).Conclusion: Rvs, as analgesic agents, may be better therapeutic agents than nonsteroidal anti-inflammatory drugs, the current choice in the relief of pain of an inflammatory origin. However, the possibility of developing adverse effects cannot be overlooked. Keywords: specialized pro-resolving lipid mediators, edema, nociception, analgesics, anti-inflammatory drugsFonseca FCSOrlando RMTurchetti-Maia RMMFrancischi JNDove Medical Pressarticleresolvin E1resolvin D1protectin DXedemanociceptionPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 10, Pp 119-133 (2017)
institution DOAJ
collection DOAJ
language EN
topic resolvin E1
resolvin D1
protectin DX
edema
nociception
Pathology
RB1-214
Therapeutics. Pharmacology
RM1-950
spellingShingle resolvin E1
resolvin D1
protectin DX
edema
nociception
Pathology
RB1-214
Therapeutics. Pharmacology
RM1-950
Fonseca FCS
Orlando RM
Turchetti-Maia RMM
Francischi JN
Comparative effects of the ω3 polyunsaturated fatty acid derivatives resolvins E1 and D1 and protectin DX in models of inflammation and pain
description Flávia CS Fonseca,1 Ricardo M Orlando,2 Regina MM Turchetti-Maia,1 Janetti Nogueira de Francischi1 1Department of Pharmacology, Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; 2Department of Chemistry, Exact Sciences Institute, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil Purpose: Specialized pro-resolving lipid mediators (SPMs), also known as lipoxins, resolvins (Rvs), protectins and maresins, have been implicated in the resolution of the inflammatory process. However, a systematic comparison of their activity in the relief of inflammation and pain models is still lacking.Materials and methods: The effects of Rvs E1 and D1 and protectin DX (PDX) were assessed in rat paws inflamed by the standard proinflammatory stimulus carrageenan or by histamine, 5-hydroxytryptamine, substance P or prostaglandin E2. The experimental outcomes were the mechanical nociceptive threshold and increase in paw volume as a measure of pain and edema formation, respectively. The analgesic and anti-inflammatory activities of the indicated SPMs were also compared with nonsteroidal (indomethacin and celecoxib) and steroidal (dexamethasone) anti-inflammatory drugs.Results: Only RvE1 and RvD1 presented analgesic and anti-inflammatory activities in the carrageenan model, and RvE1 was twice as potent as RvD1. Both substances tended to be better analgesics than anti-inflammatory agents, with a modeling profile similar to steroidal anti-inflammatory drugs. However, proinflammatory effects (edema formation) were also detected when the mediators histamine, 5-hydroxytryptamine or substance P replaced carrageenan as the proinflammatory stimuli. The analgesic and anti-inflammatory effects of resolvins were specifically prevented by an antagonist of the leukotriene B4 receptor 1 (BLT1).Conclusion: Rvs, as analgesic agents, may be better therapeutic agents than nonsteroidal anti-inflammatory drugs, the current choice in the relief of pain of an inflammatory origin. However, the possibility of developing adverse effects cannot be overlooked. Keywords: specialized pro-resolving lipid mediators, edema, nociception, analgesics, anti-inflammatory drugs
format article
author Fonseca FCS
Orlando RM
Turchetti-Maia RMM
Francischi JN
author_facet Fonseca FCS
Orlando RM
Turchetti-Maia RMM
Francischi JN
author_sort Fonseca FCS
title Comparative effects of the ω3 polyunsaturated fatty acid derivatives resolvins E1 and D1 and protectin DX in models of inflammation and pain
title_short Comparative effects of the ω3 polyunsaturated fatty acid derivatives resolvins E1 and D1 and protectin DX in models of inflammation and pain
title_full Comparative effects of the ω3 polyunsaturated fatty acid derivatives resolvins E1 and D1 and protectin DX in models of inflammation and pain
title_fullStr Comparative effects of the ω3 polyunsaturated fatty acid derivatives resolvins E1 and D1 and protectin DX in models of inflammation and pain
title_full_unstemmed Comparative effects of the ω3 polyunsaturated fatty acid derivatives resolvins E1 and D1 and protectin DX in models of inflammation and pain
title_sort comparative effects of the ω3 polyunsaturated fatty acid derivatives resolvins e1 and d1 and protectin dx in models of inflammation and pain
publisher Dove Medical Press
publishDate 2017
url https://doaj.org/article/8dd64199925c4c8f923a6d37d98d4726
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AT turchettimaiarmm comparativeeffectsoftheomega3polyunsaturatedfattyacidderivativesresolvinse1andd1andprotectindxinmodelsofinflammationandpain
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