Smooth muscle-specific MMP17 (MT4-MMP) regulates the intestinal stem cell niche and regeneration after damage

While the role of smooth muscle in peristalsis has been studied extensively, little is known about its other functions in the intestine. Here the authors identify MMP17, expressed by smooth muscle cells, as a modulator of intestinal epithelial regeneration and the intestinal stem cell niche.

Guardado en:

Detalles Bibliográficos
Autores principales:	Mara Martín-Alonso, Sharif Iqbal, Pia M. Vornewald, Håvard T. Lindholm, Mirjam J. Damen, Fernando Martínez, Sigrid Hoel, Alberto Díez-Sánchez, Maarten Altelaar, Pekka Katajisto, Alicia G. Arroyo, Menno J. Oudhoff
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8dd66dd807d54c32a63b16e262a5ef10
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8dd66dd807d54c32a63b16e262a5ef10
record_format	dspace
spelling	oai:doaj.org-article:8dd66dd807d54c32a63b16e262a5ef102021-11-21T12:34:09ZSmooth muscle-specific MMP17 (MT4-MMP) regulates the intestinal stem cell niche and regeneration after damage10.1038/s41467-021-26904-62041-1723https://doaj.org/article/8dd66dd807d54c32a63b16e262a5ef102021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26904-6https://doaj.org/toc/2041-1723While the role of smooth muscle in peristalsis has been studied extensively, little is known about its other functions in the intestine. Here the authors identify MMP17, expressed by smooth muscle cells, as a modulator of intestinal epithelial regeneration and the intestinal stem cell niche.Mara Martín-AlonsoSharif IqbalPia M. VornewaldHåvard T. LindholmMirjam J. DamenFernando MartínezSigrid HoelAlberto Díez-SánchezMaarten AltelaarPekka KatajistoAlicia G. ArroyoMenno J. OudhoffNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mara Martín-Alonso Sharif Iqbal Pia M. Vornewald Håvard T. Lindholm Mirjam J. Damen Fernando Martínez Sigrid Hoel Alberto Díez-Sánchez Maarten Altelaar Pekka Katajisto Alicia G. Arroyo Menno J. Oudhoff Smooth muscle-specific MMP17 (MT4-MMP) regulates the intestinal stem cell niche and regeneration after damage
description	While the role of smooth muscle in peristalsis has been studied extensively, little is known about its other functions in the intestine. Here the authors identify MMP17, expressed by smooth muscle cells, as a modulator of intestinal epithelial regeneration and the intestinal stem cell niche.
format	article
author	Mara Martín-Alonso Sharif Iqbal Pia M. Vornewald Håvard T. Lindholm Mirjam J. Damen Fernando Martínez Sigrid Hoel Alberto Díez-Sánchez Maarten Altelaar Pekka Katajisto Alicia G. Arroyo Menno J. Oudhoff
author_facet	Mara Martín-Alonso Sharif Iqbal Pia M. Vornewald Håvard T. Lindholm Mirjam J. Damen Fernando Martínez Sigrid Hoel Alberto Díez-Sánchez Maarten Altelaar Pekka Katajisto Alicia G. Arroyo Menno J. Oudhoff
author_sort	Mara Martín-Alonso
title	Smooth muscle-specific MMP17 (MT4-MMP) regulates the intestinal stem cell niche and regeneration after damage
title_short	Smooth muscle-specific MMP17 (MT4-MMP) regulates the intestinal stem cell niche and regeneration after damage
title_full	Smooth muscle-specific MMP17 (MT4-MMP) regulates the intestinal stem cell niche and regeneration after damage
title_fullStr	Smooth muscle-specific MMP17 (MT4-MMP) regulates the intestinal stem cell niche and regeneration after damage
title_full_unstemmed	Smooth muscle-specific MMP17 (MT4-MMP) regulates the intestinal stem cell niche and regeneration after damage
title_sort	smooth muscle-specific mmp17 (mt4-mmp) regulates the intestinal stem cell niche and regeneration after damage
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8dd66dd807d54c32a63b16e262a5ef10
work_keys_str_mv	AT maramartinalonso smoothmusclespecificmmp17mt4mmpregulatestheintestinalstemcellnicheandregenerationafterdamage AT sharifiqbal smoothmusclespecificmmp17mt4mmpregulatestheintestinalstemcellnicheandregenerationafterdamage AT piamvornewald smoothmusclespecificmmp17mt4mmpregulatestheintestinalstemcellnicheandregenerationafterdamage AT havardtlindholm smoothmusclespecificmmp17mt4mmpregulatestheintestinalstemcellnicheandregenerationafterdamage AT mirjamjdamen smoothmusclespecificmmp17mt4mmpregulatestheintestinalstemcellnicheandregenerationafterdamage AT fernandomartinez smoothmusclespecificmmp17mt4mmpregulatestheintestinalstemcellnicheandregenerationafterdamage AT sigridhoel smoothmusclespecificmmp17mt4mmpregulatestheintestinalstemcellnicheandregenerationafterdamage AT albertodiezsanchez smoothmusclespecificmmp17mt4mmpregulatestheintestinalstemcellnicheandregenerationafterdamage AT maartenaltelaar smoothmusclespecificmmp17mt4mmpregulatestheintestinalstemcellnicheandregenerationafterdamage AT pekkakatajisto smoothmusclespecificmmp17mt4mmpregulatestheintestinalstemcellnicheandregenerationafterdamage AT aliciagarroyo smoothmusclespecificmmp17mt4mmpregulatestheintestinalstemcellnicheandregenerationafterdamage AT mennojoudhoff smoothmusclespecificmmp17mt4mmpregulatestheintestinalstemcellnicheandregenerationafterdamage
_version_	1718418957578272768

Smooth muscle-specific MMP17 (MT4-MMP) regulates the intestinal stem cell niche and regeneration after damage

Ejemplares similares