Febrile Ulceronecrotic Mucha-Habermann Disease: A Rare Case Report and Review of Cases Treated With Oral Cyclosporine

We present a case of febrile ulceronecrotic Mucha-Habermann disease who presented with widespread erythematous crusted papules, which rapidly progressed to ulceronecrotic lesions accompanied by fever. The serologies showed high titers of cytomegalovirus IgG (>1:3,200) and IgM (1:800). The histopa...

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Autores principales:	Apasee Sooksamran, Poonnawis Sudtikoonaseth, Praneet Sajjachareonpong, Tanongkiet Tienthavorn
Formato:	article
Lenguaje:	EN
Publicado:	Prince of Songkla University 2021
Materias:	cyclosporine cytomegalovirus febrile ulceronecrotic mucha-habermann disease pityriasis lichenoides with ulceronecrosis and hyperthermia Medicine R
Acceso en línea:	https://doaj.org/article/8dd771f7b6f6488ea2b5fd87c8c1e004
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spelling	oai:doaj.org-article:8dd771f7b6f6488ea2b5fd87c8c1e0042021-11-25T08:25:13ZFebrile Ulceronecrotic Mucha-Habermann Disease: A Rare Case Report and Review of Cases Treated With Oral Cyclosporine2586-99812630-055910.31584/jhsmr.2021811https://doaj.org/article/8dd771f7b6f6488ea2b5fd87c8c1e0042021-11-01T00:00:00Zhttps://www.jhsmr.org/index.php/jhsmr/article/view/811https://doaj.org/toc/2586-9981https://doaj.org/toc/2630-0559We present a case of febrile ulceronecrotic Mucha-Habermann disease who presented with widespread erythematous crusted papules, which rapidly progressed to ulceronecrotic lesions accompanied by fever. The serologies showed high titers of cytomegalovirus IgG (>1:3,200) and IgM (1:800). The histopathological study showed epidermal necrosis. The treatment was begun with systemic steroids and roxithromycin to which the patient did not respond. After switching the treatment to methotrexate, the patient was further complicated by getting hepatitis. Low dose cyclosporine resolved the situation within 2 weeks. In patients for whom methotrexate is contra-indicated or ineffective, cyclosporine can suppress T-lymphocyte hyperresponsiveness and resolve this disease.Apasee SooksamranPoonnawis SudtikoonasethPraneet SajjachareonpongTanongkiet TienthavornPrince of Songkla Universityarticlecyclosporinecytomegalovirusfebrile ulceronecrotic mucha-habermann diseasepityriasis lichenoides with ulceronecrosis and hyperthermiaMedicineRENJournal of Health Science and Medical Research (JHSMR), Vol 40, Iss 1, Pp 89-94 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cyclosporine cytomegalovirus febrile ulceronecrotic mucha-habermann disease pityriasis lichenoides with ulceronecrosis and hyperthermia Medicine R
spellingShingle	cyclosporine cytomegalovirus febrile ulceronecrotic mucha-habermann disease pityriasis lichenoides with ulceronecrosis and hyperthermia Medicine R Apasee Sooksamran Poonnawis Sudtikoonaseth Praneet Sajjachareonpong Tanongkiet Tienthavorn Febrile Ulceronecrotic Mucha-Habermann Disease: A Rare Case Report and Review of Cases Treated With Oral Cyclosporine
description	We present a case of febrile ulceronecrotic Mucha-Habermann disease who presented with widespread erythematous crusted papules, which rapidly progressed to ulceronecrotic lesions accompanied by fever. The serologies showed high titers of cytomegalovirus IgG (>1:3,200) and IgM (1:800). The histopathological study showed epidermal necrosis. The treatment was begun with systemic steroids and roxithromycin to which the patient did not respond. After switching the treatment to methotrexate, the patient was further complicated by getting hepatitis. Low dose cyclosporine resolved the situation within 2 weeks. In patients for whom methotrexate is contra-indicated or ineffective, cyclosporine can suppress T-lymphocyte hyperresponsiveness and resolve this disease.
format	article
author	Apasee Sooksamran Poonnawis Sudtikoonaseth Praneet Sajjachareonpong Tanongkiet Tienthavorn
author_facet	Apasee Sooksamran Poonnawis Sudtikoonaseth Praneet Sajjachareonpong Tanongkiet Tienthavorn
author_sort	Apasee Sooksamran
title	Febrile Ulceronecrotic Mucha-Habermann Disease: A Rare Case Report and Review of Cases Treated With Oral Cyclosporine
title_short	Febrile Ulceronecrotic Mucha-Habermann Disease: A Rare Case Report and Review of Cases Treated With Oral Cyclosporine
title_full	Febrile Ulceronecrotic Mucha-Habermann Disease: A Rare Case Report and Review of Cases Treated With Oral Cyclosporine
title_fullStr	Febrile Ulceronecrotic Mucha-Habermann Disease: A Rare Case Report and Review of Cases Treated With Oral Cyclosporine
title_full_unstemmed	Febrile Ulceronecrotic Mucha-Habermann Disease: A Rare Case Report and Review of Cases Treated With Oral Cyclosporine
title_sort	febrile ulceronecrotic mucha-habermann disease: a rare case report and review of cases treated with oral cyclosporine
publisher	Prince of Songkla University
publishDate	2021
url	https://doaj.org/article/8dd771f7b6f6488ea2b5fd87c8c1e004
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Febrile Ulceronecrotic Mucha-Habermann Disease: A Rare Case Report and Review of Cases Treated With Oral Cyclosporine

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