A TRAF3-NIK module differentially regulates DNA vs RNA pathways in innate immune signaling

A TRAF3-NIK module differentially regulates DNA vs RNA pathways in innate immune signaling

The innate immunity system detects viral pathogens by sensing viral DNA or RNA via distinct pathways, but whether these pathways cross-regulate is unclear. Here the authors show that TRAF3, a known regulator of the RNA-sensing pathway, modulates an NF-κB activator NIK to control DNA-sensing by the a...

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Auteurs principaux: Kislay Parvatiyar, Jose Pindado, Anurupa Dev, Saba Roghiyh Aliyari, Shivam A. Zaver, Hoda Gerami, Maxime Chapon, Amir A. Ghaffari, Anant Dhingra, Genhong Cheng
Format: article
Langue:EN
Publié: Nature Portfolio 2018
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Accès en ligne:https://doaj.org/article/8dd7e2b5b45843c881e7492caf8c5972
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spelling oai:doaj.org-article:8dd7e2b5b45843c881e7492caf8c59722021-12-02T15:34:22ZA TRAF3-NIK module differentially regulates DNA vs RNA pathways in innate immune signaling10.1038/s41467-018-05168-72041-1723https://doaj.org/article/8dd7e2b5b45843c881e7492caf8c59722018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05168-7https://doaj.org/toc/2041-1723The innate immunity system detects viral pathogens by sensing viral DNA or RNA via distinct pathways, but whether these pathways cross-regulate is unclear. Here the authors show that TRAF3, a known regulator of the RNA-sensing pathway, modulates an NF-κB activator NIK to control DNA-sensing by the adaptor STING in immune cells.Kislay ParvatiyarJose PindadoAnurupa DevSaba Roghiyh AliyariShivam A. ZaverHoda GeramiMaxime ChaponAmir A. GhaffariAnant DhingraGenhong ChengNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Kislay Parvatiyar
Jose Pindado
Anurupa Dev
Saba Roghiyh Aliyari
Shivam A. Zaver
Hoda Gerami
Maxime Chapon
Amir A. Ghaffari
Anant Dhingra
Genhong Cheng
A TRAF3-NIK module differentially regulates DNA vs RNA pathways in innate immune signaling
description The innate immunity system detects viral pathogens by sensing viral DNA or RNA via distinct pathways, but whether these pathways cross-regulate is unclear. Here the authors show that TRAF3, a known regulator of the RNA-sensing pathway, modulates an NF-κB activator NIK to control DNA-sensing by the adaptor STING in immune cells.
format article
author Kislay Parvatiyar
Jose Pindado
Anurupa Dev
Saba Roghiyh Aliyari
Shivam A. Zaver
Hoda Gerami
Maxime Chapon
Amir A. Ghaffari
Anant Dhingra
Genhong Cheng
author_facet Kislay Parvatiyar
Jose Pindado
Anurupa Dev
Saba Roghiyh Aliyari
Shivam A. Zaver
Hoda Gerami
Maxime Chapon
Amir A. Ghaffari
Anant Dhingra
Genhong Cheng
author_sort Kislay Parvatiyar
title A TRAF3-NIK module differentially regulates DNA vs RNA pathways in innate immune signaling
title_short A TRAF3-NIK module differentially regulates DNA vs RNA pathways in innate immune signaling
title_full A TRAF3-NIK module differentially regulates DNA vs RNA pathways in innate immune signaling
title_fullStr A TRAF3-NIK module differentially regulates DNA vs RNA pathways in innate immune signaling
title_full_unstemmed A TRAF3-NIK module differentially regulates DNA vs RNA pathways in innate immune signaling
title_sort traf3-nik module differentially regulates dna vs rna pathways in innate immune signaling
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/8dd7e2b5b45843c881e7492caf8c5972
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