A TRAF3-NIK module differentially regulates DNA vs RNA pathways in innate immune signaling

The innate immunity system detects viral pathogens by sensing viral DNA or RNA via distinct pathways, but whether these pathways cross-regulate is unclear. Here the authors show that TRAF3, a known regulator of the RNA-sensing pathway, modulates an NF-κB activator NIK to control DNA-sensing by the a...

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Autores principales: Kislay Parvatiyar, Jose Pindado, Anurupa Dev, Saba Roghiyh Aliyari, Shivam A. Zaver, Hoda Gerami, Maxime Chapon, Amir A. Ghaffari, Anant Dhingra, Genhong Cheng
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/8dd7e2b5b45843c881e7492caf8c5972
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