A Zika virus vaccine expressing premembrane-envelope-NS1 polyprotein

A Zika virus vaccine expressing premembrane-envelope-NS1 polyprotein

Current Zika virus (ZIKV) subunit vaccine development largely focuses on prM and E proteins, and the role of NS1 for immune response and protection is unclear. Here, Li et al. develop an attenuated VSV-based vaccine expressing a ZIKV prM-E-NS1 polyprotein and characterize immune response and protect...

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Autores principales: Anzhong Li, Jingyou Yu, Mijia Lu, Yuanmei Ma, Zayed Attia, Chao Shan, Miaoge Xue, Xueya Liang, Kelsey Craig, Nirajkumar Makadiya, Jennifer J. He, Ryan Jennings, Pei-Yong Shi, Mark E. Peeples, Shan-Lu Liu, Prosper N. Boyaka, Jianrong Li
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/8dda5bf46f8146d19d1bf7be27066060
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spelling oai:doaj.org-article:8dda5bf46f8146d19d1bf7be270660602021-12-02T14:38:48ZA Zika virus vaccine expressing premembrane-envelope-NS1 polyprotein10.1038/s41467-018-05276-42041-1723https://doaj.org/article/8dda5bf46f8146d19d1bf7be270660602018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05276-4https://doaj.org/toc/2041-1723Current Zika virus (ZIKV) subunit vaccine development largely focuses on prM and E proteins, and the role of NS1 for immune response and protection is unclear. Here, Li et al. develop an attenuated VSV-based vaccine expressing a ZIKV prM-E-NS1 polyprotein and characterize immune response and protection in mice.Anzhong LiJingyou YuMijia LuYuanmei MaZayed AttiaChao ShanMiaoge XueXueya LiangKelsey CraigNirajkumar MakadiyaJennifer J. HeRyan JenningsPei-Yong ShiMark E. PeeplesShan-Lu LiuProsper N. BoyakaJianrong LiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Anzhong Li
Jingyou Yu
Mijia Lu
Yuanmei Ma
Zayed Attia
Chao Shan
Miaoge Xue
Xueya Liang
Kelsey Craig
Nirajkumar Makadiya
Jennifer J. He
Ryan Jennings
Pei-Yong Shi
Mark E. Peeples
Shan-Lu Liu
Prosper N. Boyaka
Jianrong Li
A Zika virus vaccine expressing premembrane-envelope-NS1 polyprotein
description Current Zika virus (ZIKV) subunit vaccine development largely focuses on prM and E proteins, and the role of NS1 for immune response and protection is unclear. Here, Li et al. develop an attenuated VSV-based vaccine expressing a ZIKV prM-E-NS1 polyprotein and characterize immune response and protection in mice.
format article
author Anzhong Li
Jingyou Yu
Mijia Lu
Yuanmei Ma
Zayed Attia
Chao Shan
Miaoge Xue
Xueya Liang
Kelsey Craig
Nirajkumar Makadiya
Jennifer J. He
Ryan Jennings
Pei-Yong Shi
Mark E. Peeples
Shan-Lu Liu
Prosper N. Boyaka
Jianrong Li
author_facet Anzhong Li
Jingyou Yu
Mijia Lu
Yuanmei Ma
Zayed Attia
Chao Shan
Miaoge Xue
Xueya Liang
Kelsey Craig
Nirajkumar Makadiya
Jennifer J. He
Ryan Jennings
Pei-Yong Shi
Mark E. Peeples
Shan-Lu Liu
Prosper N. Boyaka
Jianrong Li
author_sort Anzhong Li
title A Zika virus vaccine expressing premembrane-envelope-NS1 polyprotein
title_short A Zika virus vaccine expressing premembrane-envelope-NS1 polyprotein
title_full A Zika virus vaccine expressing premembrane-envelope-NS1 polyprotein
title_fullStr A Zika virus vaccine expressing premembrane-envelope-NS1 polyprotein
title_full_unstemmed A Zika virus vaccine expressing premembrane-envelope-NS1 polyprotein
title_sort zika virus vaccine expressing premembrane-envelope-ns1 polyprotein
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/8dda5bf46f8146d19d1bf7be27066060
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