Dynamic profiles of SARS-Cov-2 infection from five Chinese family clusters in the early stage of the COVID-19 pandemic

Abstract Although several cases of family clusters with SARS-Cov-2 infection have been reported, there are still limited data preventing conclusions from being drawn regarding the characteristics and laboratory findings in the COVID-19 population within family clusters. In the present study, we retr...

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Autores principales:	Xiang-Gen Kong, Jin Geng, Tao Zhang, Bin Wang, An-Zhao Wu, Di Xiao, Zhao-Hua Zhang, Cai-Feng Liu, Li Wang, Xue-Mei Jiang, Yu-Chen Fan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8ddcf650128f4a87b2d7aa563d6fa139
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spelling	oai:doaj.org-article:8ddcf650128f4a87b2d7aa563d6fa1392021-12-02T13:58:12ZDynamic profiles of SARS-Cov-2 infection from five Chinese family clusters in the early stage of the COVID-19 pandemic10.1038/s41598-020-79035-12045-2322https://doaj.org/article/8ddcf650128f4a87b2d7aa563d6fa1392020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79035-1https://doaj.org/toc/2045-2322Abstract Although several cases of family clusters with SARS-Cov-2 infection have been reported, there are still limited data preventing conclusions from being drawn regarding the characteristics and laboratory findings in the COVID-19 population within family clusters. In the present study, we retrospectively collected five family clusters with COVID-19 and summarized the dynamic profiles of the clinical characteristics, laboratory findings, immune markers, treatment and prognosis of this population. Furthermore, we also compared clinical and laboratory data between the SARS-Cov-2 infection with family cluster (n = 21) and those without family cluster (n = 16). We demonstrated that the duration of SARS-Cov-2 replication might be varied based on the different family clusters due to their different genetic backgrounds. The onset improved lung radiology might start at the end of the SARS-Cov-2 positive period. Furthermore, the obtained results demonstrated that similar basic characteristics and clinical findings seem to exist between the cases with SARS-Cov-2 and without family clusters. The serum level of ferritin might have a different biological function and be a new biomarker for the family cluster. Further studies with larger numbers of patients are required.Xiang-Gen KongJin GengTao ZhangBin WangAn-Zhao WuDi XiaoZhao-Hua ZhangCai-Feng LiuLi WangXue-Mei JiangYu-Chen FanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiang-Gen Kong Jin Geng Tao Zhang Bin Wang An-Zhao Wu Di Xiao Zhao-Hua Zhang Cai-Feng Liu Li Wang Xue-Mei Jiang Yu-Chen Fan Dynamic profiles of SARS-Cov-2 infection from five Chinese family clusters in the early stage of the COVID-19 pandemic
description	Abstract Although several cases of family clusters with SARS-Cov-2 infection have been reported, there are still limited data preventing conclusions from being drawn regarding the characteristics and laboratory findings in the COVID-19 population within family clusters. In the present study, we retrospectively collected five family clusters with COVID-19 and summarized the dynamic profiles of the clinical characteristics, laboratory findings, immune markers, treatment and prognosis of this population. Furthermore, we also compared clinical and laboratory data between the SARS-Cov-2 infection with family cluster (n = 21) and those without family cluster (n = 16). We demonstrated that the duration of SARS-Cov-2 replication might be varied based on the different family clusters due to their different genetic backgrounds. The onset improved lung radiology might start at the end of the SARS-Cov-2 positive period. Furthermore, the obtained results demonstrated that similar basic characteristics and clinical findings seem to exist between the cases with SARS-Cov-2 and without family clusters. The serum level of ferritin might have a different biological function and be a new biomarker for the family cluster. Further studies with larger numbers of patients are required.
format	article
author	Xiang-Gen Kong Jin Geng Tao Zhang Bin Wang An-Zhao Wu Di Xiao Zhao-Hua Zhang Cai-Feng Liu Li Wang Xue-Mei Jiang Yu-Chen Fan
author_facet	Xiang-Gen Kong Jin Geng Tao Zhang Bin Wang An-Zhao Wu Di Xiao Zhao-Hua Zhang Cai-Feng Liu Li Wang Xue-Mei Jiang Yu-Chen Fan
author_sort	Xiang-Gen Kong
title	Dynamic profiles of SARS-Cov-2 infection from five Chinese family clusters in the early stage of the COVID-19 pandemic
title_short	Dynamic profiles of SARS-Cov-2 infection from five Chinese family clusters in the early stage of the COVID-19 pandemic
title_full	Dynamic profiles of SARS-Cov-2 infection from five Chinese family clusters in the early stage of the COVID-19 pandemic
title_fullStr	Dynamic profiles of SARS-Cov-2 infection from five Chinese family clusters in the early stage of the COVID-19 pandemic
title_full_unstemmed	Dynamic profiles of SARS-Cov-2 infection from five Chinese family clusters in the early stage of the COVID-19 pandemic
title_sort	dynamic profiles of sars-cov-2 infection from five chinese family clusters in the early stage of the covid-19 pandemic
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8ddcf650128f4a87b2d7aa563d6fa139
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Dynamic profiles of SARS-Cov-2 infection from five Chinese family clusters in the early stage of the COVID-19 pandemic

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