Reticulocyte levels have an ambivalent association with hypertension and atherosclerosis in the elderly: a cross-sectional study

Yuji Shimizu,1,2 Shin-Ya Kawashiri,1 Hirotomo Yamanashi,3,4 Jun Koyamatsu,3 Shoichi Fukui,1 Hideaki Kondo,1,4 Mami Tamai,1 Seiko Nakamichi,4 Takahiro Maeda1,3–41Department of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan; 2Department of Car...

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Autores principales:	Shimizu Y, Kawashiri SY, Yamanashi H, Koyamatsu J, Fukui S, Kondo H, Tamai M, Nakamichi S, Maeda T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	atherosclerosis hypertension reticulocyte Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/8ddf1941080a4ab19a1231ead32416b9
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spelling	oai:doaj.org-article:8ddf1941080a4ab19a1231ead32416b92021-12-02T00:27:23ZReticulocyte levels have an ambivalent association with hypertension and atherosclerosis in the elderly: a cross-sectional study1178-1998https://doaj.org/article/8ddf1941080a4ab19a1231ead32416b92019-05-01T00:00:00Zhttps://www.dovepress.com/reticulocyte-levels-have-an-ambivalent-association-with-hypertension-a-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Yuji Shimizu,1,2 Shin-Ya Kawashiri,1 Hirotomo Yamanashi,3,4 Jun Koyamatsu,3 Shoichi Fukui,1 Hideaki Kondo,1,4 Mami Tamai,1 Seiko Nakamichi,4 Takahiro Maeda1,3–41Department of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan; 2Department of Cardiovascular Disease Prevention, Osaka Center for Cancer and Cardiovascular Disease Prevention, Osaka, Japan; 3Department of Island and Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan; 4Department of General Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, JapanPurpose: Age-related reduction in bone marrow activity has been shown to cause anemia, and hypertension and endothelial dysfunction (atherosclerosis) are age-related diseases. However, recent studies have revealed a close association between bone marrow activity and endothelial maintenance. This study aimed to determine the association between elevated reticulocyte levels in conjunction with vigorous bone marrow activity and hypertension and atherosclerosis among the elderly.Study population and Methods: To determine the associations between reticulocyte levels and hypertension and atherosclerosis, we conducted a cross-sectional study of 2,098 elderly Japanese individuals, aged between 60 and 89 years, who had participated in an annual health check-up in 2014.Results: Of the total study population, 1,348 individuals were diagnosed with hypertension (systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥90 mmHg and/or having used antihypertensive medication), and 393 were diagnosed with atherosclerosis (carotid intima-media thickness ≥1.1 mm). Reticulocyte levels were found to be significantly positively associated with hypertension and inversely associated with atherosclerosis. Cardiovascular risk factor-adjusted odds ratios and 95% confidence intervals for hypertension and atherosclerosis, when raised incrementally by 1 standard deviation to determine reticulocyte levels (5.5×104 cells/μL for men and 5.0×104 cells/μL for women), were 1.12 (1.01, 1.25) and 0.83 (0.72, 0.94), respectively.Conclusion: Along with established cardiovascular risk factors, reticulocyte levels in elderly Japanese individuals were found to be positively associated with hypertension and inversely associated with atherosclerosis. This finding may help clarify the background mechanisms concerning the association between bone marrow activity and vascular remodeling.Keywords: atherosclerosis, hypertension, reticulocyteShimizu YKawashiri SYYamanashi HKoyamatsu JFukui SKondo HTamai MNakamichi SMaeda TDove Medical PressarticleatherosclerosishypertensionreticulocyteGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 14, Pp 849-857 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	atherosclerosis hypertension reticulocyte Geriatrics RC952-954.6
spellingShingle	atherosclerosis hypertension reticulocyte Geriatrics RC952-954.6 Shimizu Y Kawashiri SY Yamanashi H Koyamatsu J Fukui S Kondo H Tamai M Nakamichi S Maeda T Reticulocyte levels have an ambivalent association with hypertension and atherosclerosis in the elderly: a cross-sectional study
description	Yuji Shimizu,1,2 Shin-Ya Kawashiri,1 Hirotomo Yamanashi,3,4 Jun Koyamatsu,3 Shoichi Fukui,1 Hideaki Kondo,1,4 Mami Tamai,1 Seiko Nakamichi,4 Takahiro Maeda1,3–41Department of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan; 2Department of Cardiovascular Disease Prevention, Osaka Center for Cancer and Cardiovascular Disease Prevention, Osaka, Japan; 3Department of Island and Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan; 4Department of General Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, JapanPurpose: Age-related reduction in bone marrow activity has been shown to cause anemia, and hypertension and endothelial dysfunction (atherosclerosis) are age-related diseases. However, recent studies have revealed a close association between bone marrow activity and endothelial maintenance. This study aimed to determine the association between elevated reticulocyte levels in conjunction with vigorous bone marrow activity and hypertension and atherosclerosis among the elderly.Study population and Methods: To determine the associations between reticulocyte levels and hypertension and atherosclerosis, we conducted a cross-sectional study of 2,098 elderly Japanese individuals, aged between 60 and 89 years, who had participated in an annual health check-up in 2014.Results: Of the total study population, 1,348 individuals were diagnosed with hypertension (systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥90 mmHg and/or having used antihypertensive medication), and 393 were diagnosed with atherosclerosis (carotid intima-media thickness ≥1.1 mm). Reticulocyte levels were found to be significantly positively associated with hypertension and inversely associated with atherosclerosis. Cardiovascular risk factor-adjusted odds ratios and 95% confidence intervals for hypertension and atherosclerosis, when raised incrementally by 1 standard deviation to determine reticulocyte levels (5.5×104 cells/μL for men and 5.0×104 cells/μL for women), were 1.12 (1.01, 1.25) and 0.83 (0.72, 0.94), respectively.Conclusion: Along with established cardiovascular risk factors, reticulocyte levels in elderly Japanese individuals were found to be positively associated with hypertension and inversely associated with atherosclerosis. This finding may help clarify the background mechanisms concerning the association between bone marrow activity and vascular remodeling.Keywords: atherosclerosis, hypertension, reticulocyte
format	article
author	Shimizu Y Kawashiri SY Yamanashi H Koyamatsu J Fukui S Kondo H Tamai M Nakamichi S Maeda T
author_facet	Shimizu Y Kawashiri SY Yamanashi H Koyamatsu J Fukui S Kondo H Tamai M Nakamichi S Maeda T
author_sort	Shimizu Y
title	Reticulocyte levels have an ambivalent association with hypertension and atherosclerosis in the elderly: a cross-sectional study
title_short	Reticulocyte levels have an ambivalent association with hypertension and atherosclerosis in the elderly: a cross-sectional study
title_full	Reticulocyte levels have an ambivalent association with hypertension and atherosclerosis in the elderly: a cross-sectional study
title_fullStr	Reticulocyte levels have an ambivalent association with hypertension and atherosclerosis in the elderly: a cross-sectional study
title_full_unstemmed	Reticulocyte levels have an ambivalent association with hypertension and atherosclerosis in the elderly: a cross-sectional study
title_sort	reticulocyte levels have an ambivalent association with hypertension and atherosclerosis in the elderly: a cross-sectional study
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/8ddf1941080a4ab19a1231ead32416b9
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Reticulocyte levels have an ambivalent association with hypertension and atherosclerosis in the elderly: a cross-sectional study

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