The caterpillar fungus, Ophiocordyceps sinensis, genome provides insights into highland adaptation of fungal pathogenicity
Abstract To understand the potential genetic basis of highland adaptation of fungal pathogenicity, we present here the ~116 Mb de novo assembled high-quality genome of Ophiocordyceps sinensis endemic to the Qinghai-Tibetan Plateau. Compared with other plain-dwelling fungi, we find about 3.4-fold inf...
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oai:doaj.org-article:8de04ede329a4d2d9437f043882b31372021-12-02T12:32:54ZThe caterpillar fungus, Ophiocordyceps sinensis, genome provides insights into highland adaptation of fungal pathogenicity10.1038/s41598-017-01869-z2045-2322https://doaj.org/article/8de04ede329a4d2d9437f043882b31372017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01869-zhttps://doaj.org/toc/2045-2322Abstract To understand the potential genetic basis of highland adaptation of fungal pathogenicity, we present here the ~116 Mb de novo assembled high-quality genome of Ophiocordyceps sinensis endemic to the Qinghai-Tibetan Plateau. Compared with other plain-dwelling fungi, we find about 3.4-fold inflation of the O. sinensis genome due to a rapid amplification of long terminal repeat retrotransposons that occurred ~38 million years ago in concert with the uplift of the plateau. We also observe massive removal of thousands of genes related to the transport process and energy metabolism. O. sinensis displays considerable lineage-specific expansion of gene families functionally enriched in the adaptability of low-temperature of cold tolerance, fungal pathogenicity and specialized host infection. We detect signals of positive selection for genes involved in peroxidase and hypoxia to enable its highland adaptation. Resequencing and analyzing 31 whole genomes of O. sinensis, representing nearly all of its geographic range, exhibits latitude-based population divergence and nature selection for population inhabitation towards higher altitudes on the Qinghai-Tibetan Plateau.En-Hua XiaDa-Rong YangJian-Jun JiangQun-Jie ZhangYuan LiuYun-Long LiuYun ZhangHai-Bin ZhangCong ShiYan TongChanghoon KimHua ChenYan-Qiong PengYue YuWei ZhangEvan E. EichlerLi-Zhi GaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017) |
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Medicine R Science Q En-Hua Xia Da-Rong Yang Jian-Jun Jiang Qun-Jie Zhang Yuan Liu Yun-Long Liu Yun Zhang Hai-Bin Zhang Cong Shi Yan Tong Changhoon Kim Hua Chen Yan-Qiong Peng Yue Yu Wei Zhang Evan E. Eichler Li-Zhi Gao The caterpillar fungus, Ophiocordyceps sinensis, genome provides insights into highland adaptation of fungal pathogenicity |
| description |
Abstract To understand the potential genetic basis of highland adaptation of fungal pathogenicity, we present here the ~116 Mb de novo assembled high-quality genome of Ophiocordyceps sinensis endemic to the Qinghai-Tibetan Plateau. Compared with other plain-dwelling fungi, we find about 3.4-fold inflation of the O. sinensis genome due to a rapid amplification of long terminal repeat retrotransposons that occurred ~38 million years ago in concert with the uplift of the plateau. We also observe massive removal of thousands of genes related to the transport process and energy metabolism. O. sinensis displays considerable lineage-specific expansion of gene families functionally enriched in the adaptability of low-temperature of cold tolerance, fungal pathogenicity and specialized host infection. We detect signals of positive selection for genes involved in peroxidase and hypoxia to enable its highland adaptation. Resequencing and analyzing 31 whole genomes of O. sinensis, representing nearly all of its geographic range, exhibits latitude-based population divergence and nature selection for population inhabitation towards higher altitudes on the Qinghai-Tibetan Plateau. |
| format |
article |
| author |
En-Hua Xia Da-Rong Yang Jian-Jun Jiang Qun-Jie Zhang Yuan Liu Yun-Long Liu Yun Zhang Hai-Bin Zhang Cong Shi Yan Tong Changhoon Kim Hua Chen Yan-Qiong Peng Yue Yu Wei Zhang Evan E. Eichler Li-Zhi Gao |
| author_facet |
En-Hua Xia Da-Rong Yang Jian-Jun Jiang Qun-Jie Zhang Yuan Liu Yun-Long Liu Yun Zhang Hai-Bin Zhang Cong Shi Yan Tong Changhoon Kim Hua Chen Yan-Qiong Peng Yue Yu Wei Zhang Evan E. Eichler Li-Zhi Gao |
| author_sort |
En-Hua Xia |
| title |
The caterpillar fungus, Ophiocordyceps sinensis, genome provides insights into highland adaptation of fungal pathogenicity |
| title_short |
The caterpillar fungus, Ophiocordyceps sinensis, genome provides insights into highland adaptation of fungal pathogenicity |
| title_full |
The caterpillar fungus, Ophiocordyceps sinensis, genome provides insights into highland adaptation of fungal pathogenicity |
| title_fullStr |
The caterpillar fungus, Ophiocordyceps sinensis, genome provides insights into highland adaptation of fungal pathogenicity |
| title_full_unstemmed |
The caterpillar fungus, Ophiocordyceps sinensis, genome provides insights into highland adaptation of fungal pathogenicity |
| title_sort |
caterpillar fungus, ophiocordyceps sinensis, genome provides insights into highland adaptation of fungal pathogenicity |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/8de04ede329a4d2d9437f043882b3137 |
| work_keys_str_mv |
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