Pathogenesis and Clinical Significance of In-Stent Restenosis in Patients with Diabetes

Diabetes mellitus (DM) is a strong risk factor for the development of cardiovascular diseases such as coronary heart disease, cerebrovascular disease, and peripheral arterial disease (PAD). In the population of people living with DM, PAD is characterised by multi-level atherosclerotic lesions as wel...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Grzegorz K. Jakubiak, Natalia Pawlas, Grzegorz Cieślar, Agata Stanek
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	diabetes mellitus atherosclerosis percutaneous transluminal angioplasty peripheral arterial disease restenosis in-stent restenosis Medicine R
Acceso en línea:	https://doaj.org/article/8de4e86b29c740918a1fc122e6ebca83
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8de4e86b29c740918a1fc122e6ebca83
record_format	dspace
spelling	oai:doaj.org-article:8de4e86b29c740918a1fc122e6ebca832021-11-25T17:49:54ZPathogenesis and Clinical Significance of In-Stent Restenosis in Patients with Diabetes10.3390/ijerph1822119701660-46011661-7827https://doaj.org/article/8de4e86b29c740918a1fc122e6ebca832021-11-01T00:00:00Zhttps://www.mdpi.com/1660-4601/18/22/11970https://doaj.org/toc/1661-7827https://doaj.org/toc/1660-4601Diabetes mellitus (DM) is a strong risk factor for the development of cardiovascular diseases such as coronary heart disease, cerebrovascular disease, and peripheral arterial disease (PAD). In the population of people living with DM, PAD is characterised by multi-level atherosclerotic lesions as well as greater involvement of the arteries below the knee. DM is also a factor that significantly increases the risk of lower limb amputation. Percutaneous balloon angioplasty with or without stent implantation is an important method of the treatment for atherosclerotic cardiovascular diseases, but restenosis is a factor limiting its long-term effectiveness. The pathogenesis of atherosclerosis in the course of DM differs slightly from that in the general population. In the population of people living with DM, more attention is drawn to such factors as inflammation, endothelial dysfunction, platelet dysfunction, blood rheological properties, hypercoagulability, and additional factors stimulating vascular smooth muscle cell proliferation. DM is a risk factor for restenosis. The purpose of this paper is to provide a review of the literature and to present the most important information on the current state of knowledge on mechanisms and the clinical significance of restenosis and in-stent restenosis in patients with DM, especially in association with the endovascular treatment of PAD. The role of such processes as inflammation, neointimal hyperplasia and neoatherosclerosis, allergy, resistance to antimitotic drugs used for coating stents and balloons, genetic factors, and technical and mechanical factors are discussed. The information on restenosis collected in this publication may be helpful in planning further research in this field, which may contribute to the formulation of more and more precise recommendations for the clinical practice.Grzegorz K. JakubiakNatalia PawlasGrzegorz CieślarAgata StanekMDPI AGarticlediabetes mellitusatherosclerosispercutaneous transluminal angioplastyperipheral arterial diseaserestenosisin-stent restenosisMedicineRENInternational Journal of Environmental Research and Public Health, Vol 18, Iss 11970, p 11970 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetes mellitus atherosclerosis percutaneous transluminal angioplasty peripheral arterial disease restenosis in-stent restenosis Medicine R
spellingShingle	diabetes mellitus atherosclerosis percutaneous transluminal angioplasty peripheral arterial disease restenosis in-stent restenosis Medicine R Grzegorz K. Jakubiak Natalia Pawlas Grzegorz Cieślar Agata Stanek Pathogenesis and Clinical Significance of In-Stent Restenosis in Patients with Diabetes
description	Diabetes mellitus (DM) is a strong risk factor for the development of cardiovascular diseases such as coronary heart disease, cerebrovascular disease, and peripheral arterial disease (PAD). In the population of people living with DM, PAD is characterised by multi-level atherosclerotic lesions as well as greater involvement of the arteries below the knee. DM is also a factor that significantly increases the risk of lower limb amputation. Percutaneous balloon angioplasty with or without stent implantation is an important method of the treatment for atherosclerotic cardiovascular diseases, but restenosis is a factor limiting its long-term effectiveness. The pathogenesis of atherosclerosis in the course of DM differs slightly from that in the general population. In the population of people living with DM, more attention is drawn to such factors as inflammation, endothelial dysfunction, platelet dysfunction, blood rheological properties, hypercoagulability, and additional factors stimulating vascular smooth muscle cell proliferation. DM is a risk factor for restenosis. The purpose of this paper is to provide a review of the literature and to present the most important information on the current state of knowledge on mechanisms and the clinical significance of restenosis and in-stent restenosis in patients with DM, especially in association with the endovascular treatment of PAD. The role of such processes as inflammation, neointimal hyperplasia and neoatherosclerosis, allergy, resistance to antimitotic drugs used for coating stents and balloons, genetic factors, and technical and mechanical factors are discussed. The information on restenosis collected in this publication may be helpful in planning further research in this field, which may contribute to the formulation of more and more precise recommendations for the clinical practice.
format	article
author	Grzegorz K. Jakubiak Natalia Pawlas Grzegorz Cieślar Agata Stanek
author_facet	Grzegorz K. Jakubiak Natalia Pawlas Grzegorz Cieślar Agata Stanek
author_sort	Grzegorz K. Jakubiak
title	Pathogenesis and Clinical Significance of In-Stent Restenosis in Patients with Diabetes
title_short	Pathogenesis and Clinical Significance of In-Stent Restenosis in Patients with Diabetes
title_full	Pathogenesis and Clinical Significance of In-Stent Restenosis in Patients with Diabetes
title_fullStr	Pathogenesis and Clinical Significance of In-Stent Restenosis in Patients with Diabetes
title_full_unstemmed	Pathogenesis and Clinical Significance of In-Stent Restenosis in Patients with Diabetes
title_sort	pathogenesis and clinical significance of in-stent restenosis in patients with diabetes
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8de4e86b29c740918a1fc122e6ebca83
work_keys_str_mv	AT grzegorzkjakubiak pathogenesisandclinicalsignificanceofinstentrestenosisinpatientswithdiabetes AT nataliapawlas pathogenesisandclinicalsignificanceofinstentrestenosisinpatientswithdiabetes AT grzegorzcieslar pathogenesisandclinicalsignificanceofinstentrestenosisinpatientswithdiabetes AT agatastanek pathogenesisandclinicalsignificanceofinstentrestenosisinpatientswithdiabetes
_version_	1718411997501980672

Pathogenesis and Clinical Significance of In-Stent Restenosis in Patients with Diabetes

Ejemplares similares