Concurrent electrophysiological recording and cognitive testing in a rodent touchscreen environment

Abstract Challenges in therapeutics development for neuropsychiatric disorders can be attributed, in part, to a paucity of translational models capable of capturing relevant phenotypes across clinical populations and laboratory animals. Touch-sensitive procedures are increasingly used to develop inn...

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Autores principales:	Brian D. Kangas, Ann M. Iturra-Mena, Mykel A. Robble, Oanh T. Luc, David Potter, Stefanie Nickels, Jack Bergman, William A. Carlezon, Diego A. Pizzagalli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8de76002fb0149ac945603cf53051845
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spelling	oai:doaj.org-article:8de76002fb0149ac945603cf530518452021-12-02T17:51:21ZConcurrent electrophysiological recording and cognitive testing in a rodent touchscreen environment10.1038/s41598-021-91091-92045-2322https://doaj.org/article/8de76002fb0149ac945603cf530518452021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91091-9https://doaj.org/toc/2045-2322Abstract Challenges in therapeutics development for neuropsychiatric disorders can be attributed, in part, to a paucity of translational models capable of capturing relevant phenotypes across clinical populations and laboratory animals. Touch-sensitive procedures are increasingly used to develop innovative animal models that better align with testing conditions used in human participants. In addition, advances in electrophysiological techniques have identified neurophysiological signatures associated with characteristics of neuropsychiatric illness. The present studies integrated these methodologies by developing a rat flanker task with electrophysiological recordings based on reverse-translated protocols used in human electroencephalogram (EEG) studies of cognitive control. Various touchscreen-based stimuli were evaluated for their ability to efficiently gain stimulus control and advance to flanker test sessions. Optimized stimuli were then examined for their elicitation of prototypical visual evoked potentials (VEPs) across local field potential (LFP) wires and EEG skull screws. Of the stimuli evaluated, purple and green photographic stimuli were associated with efficient training and expected flanker interference effects. Orderly stimulus-locked outcomes were also observed in VEPs across LFP and EEG recordings. These studies along with others verify the feasibility of concurrent electrophysiological recordings and rodent touchscreen-based cognitive testing and encourage future use of this integrated approach in therapeutics development.Brian D. KangasAnn M. Iturra-MenaMykel A. RobbleOanh T. LucDavid PotterStefanie NickelsJack BergmanWilliam A. CarlezonDiego A. PizzagalliNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Brian D. Kangas Ann M. Iturra-Mena Mykel A. Robble Oanh T. Luc David Potter Stefanie Nickels Jack Bergman William A. Carlezon Diego A. Pizzagalli Concurrent electrophysiological recording and cognitive testing in a rodent touchscreen environment
description	Abstract Challenges in therapeutics development for neuropsychiatric disorders can be attributed, in part, to a paucity of translational models capable of capturing relevant phenotypes across clinical populations and laboratory animals. Touch-sensitive procedures are increasingly used to develop innovative animal models that better align with testing conditions used in human participants. In addition, advances in electrophysiological techniques have identified neurophysiological signatures associated with characteristics of neuropsychiatric illness. The present studies integrated these methodologies by developing a rat flanker task with electrophysiological recordings based on reverse-translated protocols used in human electroencephalogram (EEG) studies of cognitive control. Various touchscreen-based stimuli were evaluated for their ability to efficiently gain stimulus control and advance to flanker test sessions. Optimized stimuli were then examined for their elicitation of prototypical visual evoked potentials (VEPs) across local field potential (LFP) wires and EEG skull screws. Of the stimuli evaluated, purple and green photographic stimuli were associated with efficient training and expected flanker interference effects. Orderly stimulus-locked outcomes were also observed in VEPs across LFP and EEG recordings. These studies along with others verify the feasibility of concurrent electrophysiological recordings and rodent touchscreen-based cognitive testing and encourage future use of this integrated approach in therapeutics development.
format	article
author	Brian D. Kangas Ann M. Iturra-Mena Mykel A. Robble Oanh T. Luc David Potter Stefanie Nickels Jack Bergman William A. Carlezon Diego A. Pizzagalli
author_facet	Brian D. Kangas Ann M. Iturra-Mena Mykel A. Robble Oanh T. Luc David Potter Stefanie Nickels Jack Bergman William A. Carlezon Diego A. Pizzagalli
author_sort	Brian D. Kangas
title	Concurrent electrophysiological recording and cognitive testing in a rodent touchscreen environment
title_short	Concurrent electrophysiological recording and cognitive testing in a rodent touchscreen environment
title_full	Concurrent electrophysiological recording and cognitive testing in a rodent touchscreen environment
title_fullStr	Concurrent electrophysiological recording and cognitive testing in a rodent touchscreen environment
title_full_unstemmed	Concurrent electrophysiological recording and cognitive testing in a rodent touchscreen environment
title_sort	concurrent electrophysiological recording and cognitive testing in a rodent touchscreen environment
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8de76002fb0149ac945603cf53051845
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Concurrent electrophysiological recording and cognitive testing in a rodent touchscreen environment

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