Repertoire-scale determination of class II MHC peptide binding via yeast display improves antigen prediction

Identifying peptides that can bind major histocompatibility complex II (MHC-II) is important for our understanding of T cell immunity and specificity. Here the authors present a yeast-display library screening approach that identifies more potential binders than various reported algorithms to help e...

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Autores principales:	C. Garrett Rappazzo, Brooke D. Huisman, Michael E. Birnbaum
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8de8cc1f22874ebb952282dd1b637f54
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spelling	oai:doaj.org-article:8de8cc1f22874ebb952282dd1b637f542021-12-02T16:38:50ZRepertoire-scale determination of class II MHC peptide binding via yeast display improves antigen prediction10.1038/s41467-020-18204-22041-1723https://doaj.org/article/8de8cc1f22874ebb952282dd1b637f542020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18204-2https://doaj.org/toc/2041-1723Identifying peptides that can bind major histocompatibility complex II (MHC-II) is important for our understanding of T cell immunity and specificity. Here the authors present a yeast-display library screening approach that identifies more potential binders than various reported algorithms to help expand our understanding for antigen presentation.C. Garrett RappazzoBrooke D. HuismanMichael E. BirnbaumNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q C. Garrett Rappazzo Brooke D. Huisman Michael E. Birnbaum Repertoire-scale determination of class II MHC peptide binding via yeast display improves antigen prediction
description	Identifying peptides that can bind major histocompatibility complex II (MHC-II) is important for our understanding of T cell immunity and specificity. Here the authors present a yeast-display library screening approach that identifies more potential binders than various reported algorithms to help expand our understanding for antigen presentation.
format	article
author	C. Garrett Rappazzo Brooke D. Huisman Michael E. Birnbaum
author_facet	C. Garrett Rappazzo Brooke D. Huisman Michael E. Birnbaum
author_sort	C. Garrett Rappazzo
title	Repertoire-scale determination of class II MHC peptide binding via yeast display improves antigen prediction
title_short	Repertoire-scale determination of class II MHC peptide binding via yeast display improves antigen prediction
title_full	Repertoire-scale determination of class II MHC peptide binding via yeast display improves antigen prediction
title_fullStr	Repertoire-scale determination of class II MHC peptide binding via yeast display improves antigen prediction
title_full_unstemmed	Repertoire-scale determination of class II MHC peptide binding via yeast display improves antigen prediction
title_sort	repertoire-scale determination of class ii mhc peptide binding via yeast display improves antigen prediction
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8de8cc1f22874ebb952282dd1b637f54
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Repertoire-scale determination of class II MHC peptide binding via yeast display improves antigen prediction

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