Estrogen Regulates Bone Turnover by Targeting RANKL Expression in Bone Lining Cells

Abstract Estrogen is critical for skeletal homeostasis and regulates bone remodeling, in part, by modulating the expression of receptor activator of NF-κB ligand (RANKL), an essential cytokine for bone resorption by osteoclasts. RANKL can be produced by a variety of hematopoietic (e.g. T and B-cell)...

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Autores principales:	Carmen Streicher, Alexandra Heyny, Olena Andrukhova, Barbara Haigl, Svetlana Slavic, Christiane Schüler, Karoline Kollmann, Ingrid Kantner, Veronika Sexl, Miriam Kleiter, Lorenz C. Hofbauer, Paul J. Kostenuik, Reinhold G. Erben
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8deacb25c8e6455ab90cd1d806872bfd
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spelling	oai:doaj.org-article:8deacb25c8e6455ab90cd1d806872bfd2021-12-02T11:52:27ZEstrogen Regulates Bone Turnover by Targeting RANKL Expression in Bone Lining Cells10.1038/s41598-017-06614-02045-2322https://doaj.org/article/8deacb25c8e6455ab90cd1d806872bfd2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06614-0https://doaj.org/toc/2045-2322Abstract Estrogen is critical for skeletal homeostasis and regulates bone remodeling, in part, by modulating the expression of receptor activator of NF-κB ligand (RANKL), an essential cytokine for bone resorption by osteoclasts. RANKL can be produced by a variety of hematopoietic (e.g. T and B-cell) and mesenchymal (osteoblast lineage, chondrocyte) cell types. The cellular mechanisms by which estrogen acts on bone are still a matter of controversy. By using murine reconstitution models that allow for selective deletion of estrogen receptor-alpha (ERα) or selective inhibition of RANKL in hematopoietic vs. mesenchymal cells, in conjunction with in situ expression profiling in bone cells, we identified bone lining cells as important gatekeepers of estrogen-controlled bone resorption. Our data indicate that the increase in bone resorption observed in states of estrogen deficiency in mice is mainly caused by lack of ERα-mediated suppression of RANKL expression in bone lining cells.Carmen StreicherAlexandra HeynyOlena AndrukhovaBarbara HaiglSvetlana SlavicChristiane SchülerKaroline KollmannIngrid KantnerVeronika SexlMiriam KleiterLorenz C. HofbauerPaul J. KostenuikReinhold G. ErbenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Carmen Streicher Alexandra Heyny Olena Andrukhova Barbara Haigl Svetlana Slavic Christiane Schüler Karoline Kollmann Ingrid Kantner Veronika Sexl Miriam Kleiter Lorenz C. Hofbauer Paul J. Kostenuik Reinhold G. Erben Estrogen Regulates Bone Turnover by Targeting RANKL Expression in Bone Lining Cells
description	Abstract Estrogen is critical for skeletal homeostasis and regulates bone remodeling, in part, by modulating the expression of receptor activator of NF-κB ligand (RANKL), an essential cytokine for bone resorption by osteoclasts. RANKL can be produced by a variety of hematopoietic (e.g. T and B-cell) and mesenchymal (osteoblast lineage, chondrocyte) cell types. The cellular mechanisms by which estrogen acts on bone are still a matter of controversy. By using murine reconstitution models that allow for selective deletion of estrogen receptor-alpha (ERα) or selective inhibition of RANKL in hematopoietic vs. mesenchymal cells, in conjunction with in situ expression profiling in bone cells, we identified bone lining cells as important gatekeepers of estrogen-controlled bone resorption. Our data indicate that the increase in bone resorption observed in states of estrogen deficiency in mice is mainly caused by lack of ERα-mediated suppression of RANKL expression in bone lining cells.
format	article
author	Carmen Streicher Alexandra Heyny Olena Andrukhova Barbara Haigl Svetlana Slavic Christiane Schüler Karoline Kollmann Ingrid Kantner Veronika Sexl Miriam Kleiter Lorenz C. Hofbauer Paul J. Kostenuik Reinhold G. Erben
author_facet	Carmen Streicher Alexandra Heyny Olena Andrukhova Barbara Haigl Svetlana Slavic Christiane Schüler Karoline Kollmann Ingrid Kantner Veronika Sexl Miriam Kleiter Lorenz C. Hofbauer Paul J. Kostenuik Reinhold G. Erben
author_sort	Carmen Streicher
title	Estrogen Regulates Bone Turnover by Targeting RANKL Expression in Bone Lining Cells
title_short	Estrogen Regulates Bone Turnover by Targeting RANKL Expression in Bone Lining Cells
title_full	Estrogen Regulates Bone Turnover by Targeting RANKL Expression in Bone Lining Cells
title_fullStr	Estrogen Regulates Bone Turnover by Targeting RANKL Expression in Bone Lining Cells
title_full_unstemmed	Estrogen Regulates Bone Turnover by Targeting RANKL Expression in Bone Lining Cells
title_sort	estrogen regulates bone turnover by targeting rankl expression in bone lining cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8deacb25c8e6455ab90cd1d806872bfd
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Estrogen Regulates Bone Turnover by Targeting RANKL Expression in Bone Lining Cells

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