The temporal relationship between parental concern of overeating and childhood obesity considering genetic susceptibility: longitudinal results from the IDEFICS/I.Family study

Abstract Background Many genes and molecular pathways are associated with obesity, but the mechanisms from genes to obesity are less well known. Eating behaviors represent a plausible pathway, but because the relationships of eating behaviors and obesity may be bi-directional, it remains challenging...

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Autores principales:	Guiomar Masip, Ronja Foraita, Karri Silventoinen, Roger A. H. Adan, Wolfgang Ahrens, Stefaan De Henauw, Antje Hebestreit, Anna Keski-Rahkonen, Lauren Lissner, Kirsten Mehlig, Dénés Molnar, Luis A. Moreno, Iris Pigeot, Paola Russo, Toomas Veidebaum, Leonie H. Bogl, Jaakko Kaprio, on behalf of the IDEFICS/I.Family Consortia
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Obesity Overeating Polygenic risk score Body mass index Genetics Temporal associations Nutritional diseases. Deficiency diseases RC620-627 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/8deb51fdf686420d849517a1ffb0d825
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spelling	oai:doaj.org-article:8deb51fdf686420d849517a1ffb0d8252021-11-08T11:18:49ZThe temporal relationship between parental concern of overeating and childhood obesity considering genetic susceptibility: longitudinal results from the IDEFICS/I.Family study10.1186/s12966-021-01205-91479-5868https://doaj.org/article/8deb51fdf686420d849517a1ffb0d8252021-11-01T00:00:00Zhttps://doi.org/10.1186/s12966-021-01205-9https://doaj.org/toc/1479-5868Abstract Background Many genes and molecular pathways are associated with obesity, but the mechanisms from genes to obesity are less well known. Eating behaviors represent a plausible pathway, but because the relationships of eating behaviors and obesity may be bi-directional, it remains challenging to resolve the underlying pathways. A longitudinal approach is needed to assess the contribution of genetic risk during the development of obesity in childhood. In this study we aim to examine the relationships between the polygenic risk score for body mass index (PRS-BMI), parental concern of overeating and obesity indices during childhood. Methods The IDEFICS/I.Family study is a school-based multicenter pan-European cohort of children observed for 6 years (mean ± SD follow-up 5.8 ± 0.4). Children examined in 2007/2008 (wave 1) (mean ± SD age: 4.4 ± 1.1, range: 2–9 years), in 2009/2010 (wave 2) and in 2013/2014 (wave 3) were included. A total of 5112 children (49% girls) participated at waves 1, 2 and 3. For 2656 children with genome-wide data we constructed a PRS based on 2.1 million single nucleotide polymorphisms. Z-score BMI and z-score waist circumference (WC) were assessed and eating behaviors and relevant confounders were reported by parents via questionnaires. Parental concern of overeating was derived from principal component analyses from an eating behavior questionnaire. Results In cross-lagged models, the prospective associations between z-score obesity indices and parental concern of overeating were bi-directional. In mediation models, the association between the PRS-BMI and parental concern of overeating at wave 3 was mediated by baseline z-BMI (β = 0.16, 95% CI: 0.10, 0.21) and baseline z-WC (β = 0.17, 95% CI: 0.11, 0.23). To a lesser extent, baseline parental concern of overeating also mediated the association between the PRS-BMI and z-BMI at wave 3 (β = 0.10, 95% CI: 0.07, 0.13) and z-WC at wave 3 (β = 0.09, 95% CI: 0.07, 0.12). Conclusions The findings suggest that the prospective associations between obesity indices and parental concern of overeating are likely bi-directional, but obesity indices have a stronger association with future parental concern of overeating than vice versa. The findings suggest parental concern of overeating as a possible mediator in the genetic susceptibility to obesity and further highlight that other pathways are also involved. A better understanding of the genetic pathways that lead to childhood obesity can help to prevent weight gain. Trial registration Registry number: ISRCTN62310987 Retrospectively registered 17 September 2018.Guiomar MasipRonja ForaitaKarri SilventoinenRoger A. H. AdanWolfgang AhrensStefaan De HenauwAntje HebestreitAnna Keski-RahkonenLauren LissnerKirsten MehligDénés MolnarLuis A. MorenoIris PigeotPaola RussoToomas VeidebaumLeonie H. BoglJaakko Kaprioon behalf of the IDEFICS/I.Family ConsortiaBMCarticleObesityOvereatingPolygenic risk scoreBody mass indexGeneticsTemporal associationsNutritional diseases. Deficiency diseasesRC620-627Public aspects of medicineRA1-1270ENInternational Journal of Behavioral Nutrition and Physical Activity, Vol 18, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Obesity Overeating Polygenic risk score Body mass index Genetics Temporal associations Nutritional diseases. Deficiency diseases RC620-627 Public aspects of medicine RA1-1270
spellingShingle	Obesity Overeating Polygenic risk score Body mass index Genetics Temporal associations Nutritional diseases. Deficiency diseases RC620-627 Public aspects of medicine RA1-1270 Guiomar Masip Ronja Foraita Karri Silventoinen Roger A. H. Adan Wolfgang Ahrens Stefaan De Henauw Antje Hebestreit Anna Keski-Rahkonen Lauren Lissner Kirsten Mehlig Dénés Molnar Luis A. Moreno Iris Pigeot Paola Russo Toomas Veidebaum Leonie H. Bogl Jaakko Kaprio on behalf of the IDEFICS/I.Family Consortia The temporal relationship between parental concern of overeating and childhood obesity considering genetic susceptibility: longitudinal results from the IDEFICS/I.Family study
description	Abstract Background Many genes and molecular pathways are associated with obesity, but the mechanisms from genes to obesity are less well known. Eating behaviors represent a plausible pathway, but because the relationships of eating behaviors and obesity may be bi-directional, it remains challenging to resolve the underlying pathways. A longitudinal approach is needed to assess the contribution of genetic risk during the development of obesity in childhood. In this study we aim to examine the relationships between the polygenic risk score for body mass index (PRS-BMI), parental concern of overeating and obesity indices during childhood. Methods The IDEFICS/I.Family study is a school-based multicenter pan-European cohort of children observed for 6 years (mean ± SD follow-up 5.8 ± 0.4). Children examined in 2007/2008 (wave 1) (mean ± SD age: 4.4 ± 1.1, range: 2–9 years), in 2009/2010 (wave 2) and in 2013/2014 (wave 3) were included. A total of 5112 children (49% girls) participated at waves 1, 2 and 3. For 2656 children with genome-wide data we constructed a PRS based on 2.1 million single nucleotide polymorphisms. Z-score BMI and z-score waist circumference (WC) were assessed and eating behaviors and relevant confounders were reported by parents via questionnaires. Parental concern of overeating was derived from principal component analyses from an eating behavior questionnaire. Results In cross-lagged models, the prospective associations between z-score obesity indices and parental concern of overeating were bi-directional. In mediation models, the association between the PRS-BMI and parental concern of overeating at wave 3 was mediated by baseline z-BMI (β = 0.16, 95% CI: 0.10, 0.21) and baseline z-WC (β = 0.17, 95% CI: 0.11, 0.23). To a lesser extent, baseline parental concern of overeating also mediated the association between the PRS-BMI and z-BMI at wave 3 (β = 0.10, 95% CI: 0.07, 0.13) and z-WC at wave 3 (β = 0.09, 95% CI: 0.07, 0.12). Conclusions The findings suggest that the prospective associations between obesity indices and parental concern of overeating are likely bi-directional, but obesity indices have a stronger association with future parental concern of overeating than vice versa. The findings suggest parental concern of overeating as a possible mediator in the genetic susceptibility to obesity and further highlight that other pathways are also involved. A better understanding of the genetic pathways that lead to childhood obesity can help to prevent weight gain. Trial registration Registry number: ISRCTN62310987 Retrospectively registered 17 September 2018.
format	article
author	Guiomar Masip Ronja Foraita Karri Silventoinen Roger A. H. Adan Wolfgang Ahrens Stefaan De Henauw Antje Hebestreit Anna Keski-Rahkonen Lauren Lissner Kirsten Mehlig Dénés Molnar Luis A. Moreno Iris Pigeot Paola Russo Toomas Veidebaum Leonie H. Bogl Jaakko Kaprio on behalf of the IDEFICS/I.Family Consortia
author_facet	Guiomar Masip Ronja Foraita Karri Silventoinen Roger A. H. Adan Wolfgang Ahrens Stefaan De Henauw Antje Hebestreit Anna Keski-Rahkonen Lauren Lissner Kirsten Mehlig Dénés Molnar Luis A. Moreno Iris Pigeot Paola Russo Toomas Veidebaum Leonie H. Bogl Jaakko Kaprio on behalf of the IDEFICS/I.Family Consortia
author_sort	Guiomar Masip
title	The temporal relationship between parental concern of overeating and childhood obesity considering genetic susceptibility: longitudinal results from the IDEFICS/I.Family study
title_short	The temporal relationship between parental concern of overeating and childhood obesity considering genetic susceptibility: longitudinal results from the IDEFICS/I.Family study
title_full	The temporal relationship between parental concern of overeating and childhood obesity considering genetic susceptibility: longitudinal results from the IDEFICS/I.Family study
title_fullStr	The temporal relationship between parental concern of overeating and childhood obesity considering genetic susceptibility: longitudinal results from the IDEFICS/I.Family study
title_full_unstemmed	The temporal relationship between parental concern of overeating and childhood obesity considering genetic susceptibility: longitudinal results from the IDEFICS/I.Family study
title_sort	temporal relationship between parental concern of overeating and childhood obesity considering genetic susceptibility: longitudinal results from the idefics/i.family study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/8deb51fdf686420d849517a1ffb0d825
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The temporal relationship between parental concern of overeating and childhood obesity considering genetic susceptibility: longitudinal results from the IDEFICS/I.Family study

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